Friedreich's ataxia medical therapy

Jump to: navigation, search

Friedreich's ataxia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Friedreich's ataxia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Friedreich's ataxia medical therapy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Friedreich's ataxia medical therapy

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Friedreich's ataxia medical therapy

CDC on Friedreich's ataxia medical therapy

Friedreich's ataxia medical therapy in the news

Blogs on Friedreich's ataxia medical therapy

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Friedreich's ataxia medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

Pharmacologic medical therapy is recommended among patients with Friedreich's ataxia but their affect in decrease the symptoms of Friedreich's ataxia is not significant. Pharmacologic medical therapies for Friedreich's ataxia include Physostigmine, Riluzole and Amantadine. The rationale for evaluating physostigmine in ataxia, including Friedreich's ataxia, is its inhibition of acetylcholinesterase, which prolongs central and peripheral effects of acetylcholine. The mechanism of action of Riluzole may be related to the small conductance calcium-activated potassium channels that appear to regulate excitability in neurons found within deep cerebellar nuclei. Amantadine may be helpfull in the treatment of the patients with Freidreich's ataxia.

Medical Therapy

  • Pharmacologic medical therapy is recommended among patients with Friedreich's ataxia but their affect in decrease the symptoms of Friedreich's ataxia is not significant.[1]
  • Pharmacologic medical therapies for Friedreich's ataxia include Physostigmine, Riluzole and Amantadine.

• Physostigmine

The rationale for evaluating physostigmine in ataxia, including Friedreich's ataxia, is its inhibition of acetylcholinesterase, which prolongs central and peripheral effects of acetylcholine.[1]

• Riluzole

The mechanism of action of Riluzole may be related to the small conductance calcium-activated potassium channels that appear to regulate excitability in neurons found within deep cerebellar nuclei.

• Amantadine

Amantadine may be helpfull in the treatment of the patients with Freidreich's ataxia.

References

  1. 1.0 1.1 Escudero E, Moreyra A, Iveli C, Lardani H, Cingolani HE (April 1973). "[Myocardial contractility: an experimental analysis of various proposed indices]". Acta Physiol Lat Am (in Spanish; Castilian). 23 (4): 250–69. PMID 4768799.

Linked-in.jpg