Butyrophenone
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| Butyrophenone | |
|---|---|
| IUPAC name | 1-cyclohexylbutan-1-one |
| Identifiers | |
| CAS number | |
| PubChem | |
| SMILES | CCCC(=O)C1=CC=CC=C1 |
| Properties | |
| Molecular formula | C10H12O |
| Molar mass | 148.202 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
Butyrophenone is a chemical compound (a ketone); some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.
Butyrophenones are a class of pharmaceutical drugs derived from butyrophenone.
Examples include:
- Haloperidol, the most widely-used drug in this class
- Droperidol, often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment
- Benperidol, the most potent commonly-used antipsychotic (~ 200 times more potent as chlorpromazine)
- Triperidol, a highly-potent antipsychotic (100 times more potent than chlorpromazine)
- Melperone, a weakly-potent antipsychotic, in Europe commonly used for treatment of insomnia, confusional states, psychomotor agitation, and delirium, in particular, in geriatric patients
- Lenperone
- Domperidone, an dopamine-antagonist antiemetic, derived further from butyrophenone (not being a butyrophenone itself).
The atypical antipsychotic risperidone, although not a butyrophenone, was developed with the structures of benperidol and lenperone as a basis.
Psycholeptics: antipsychotics (N05A) | |
|---|---|
| Phenothiazine typical antipsychotics | Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine • Triflupromazine |
| Other typical antipsychotics | Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Bromperidol, Droperidol, Haloperidol, Trifluperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine) |
| Atypical antipsychotics | Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine) |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
