Melperone
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| Image:Melperone skeletal.svg | |
| Melperone
| |
| Systematic (IUPAC) name | |
| 1-(4-fluorophenyl)-4-(4-methyl-1-piperidyl)butan-1-one | |
| Identifiers | |
| CAS number | |
| ATC code | N05 |
| PubChem | |
| Chemical data | |
| Formula | C16H22FNO |
| Mol. mass | 263.35 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Hepatic (inhibits CYP2D6[1]) |
| Half life | 3–4 hours (oral) 6 hours (IM) |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral, intramuscular injection |
Melperone (INN, also known as methylperone) is a butyrophenone atypical antipsychotic. It is sold under the trade names Buronil, Burnil, and Eunerpan.
Chemistry
- Appearance: White, crystalline odorless powder
- Solubility: Freely soluble in water. Freely soluble in ethanol 99.5% and chloroform. Practically insoluble in diethyl ether.
- Melting Point: 205-210C
- pH (1% in water): 4.5-6.5
- Stability: 48 months
It is a white crystalline powder that is manufactured by Dupont Chemoswed (Sweden). It is a butyrophenone (1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride).
References
- ↑ Grözinger M, Dragicevic A, Hiemke C, Shams M, Müller MJ, Härtter S (2003). "Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine". Pharmacopsychiatry 36 (1): 3–6. doi:10.1055/s-2003-38084. PMID 12649767.
External links
Psycholeptics: antipsychotics (N05A) | |
|---|---|
| Phenothiazine typical antipsychotics | Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine • Triflupromazine |
| Other typical antipsychotics | Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Bromperidol, Droperidol, Haloperidol, Trifluperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine) |
| Atypical antipsychotics | Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine) |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
