Bone morphogenetic protein 1
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| Bone morphogenetic protein 1 | |
|---|---|
| Other names: | procollagen C-endopeptidase (PCOLC) |
| Genetic data | |
| Gene code: | HUGO code:BMP1 |
| Protein Structure/Function | |
| Functions: | cell signalling, cell differentiation,cartilage condensation, proteolysis, ossification |
| Domains: | ZnMc,CUB,EGFCA |
| Other | |
| Taxa expressing: | Homo sapiens; homologs: many metazoan phyla |
| Cell types: | Skin, Brain, Placenta, Liver, Pancreas, Muscle |
| Subcellular localization: | extracellular |
| Covalent modifications: | Glycosylation |
Bone morphogenetic protein 1 (BMP1) is a protein that belongs to the peptidase M12A family of proteins. It induces bone and cartilage development. It is unlike other bone morphogenetic proteins since it does not belong to the TGFβ superfamily of proteins. It was initially discovered to work like other bone morphogenetic proteins by inducing bone and cartilage development. It however, is a metalloprotease that cleaves the C-terminus of procollagen I, II and III. It has an astacin-like protease domain.
It has been shown to cleave laminin 5 and is localized in the basal epithelial layer of bovine skin.
There are seven isoforms of the enzyme created by alternate splicing.
| '
| |
| Identifiers | |
| Symbol | BMP1 |
| Alt. Symbols | PCOLC |
| Entrez | 649 |
| HUGO | 1067 |
| OMIM | 112264 |
| RefSeq | NM_006132 |
| UniProt | P13497 |
| Other data | |
| EC number | 3.4.24.19 |
| Locus | Chr. 8 p21 |
External links
Template:Molecular-cell-biology-stub
Proteases: metalloendopeptidases (EC 3.4.24) | |
|---|---|
| ADAM protein | ADAMTS2 - ADAMTS13 - ADAMTS5 - ADAM17 - Alpha secretase |
| Matrix metalloproteinase | Collagenase - Gelatinase |
| Other | Neprilysin - Procollagen peptidase - Thermolysin - Pregnancy-associated plasma protein A - Bone morphogenetic protein 1 - Insulysin - Lysostaphin |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
