ADAM protein

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Adam protein (A Disintegrin and Metalloproteinase Protein) is a family of peptidase proteins^[1]. ADAMs are also known as the Adamalysin family. ADAMs are classified as Sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM 10 can cut off part of the HER2 receptor, activating it^[1] and ADAM 17 can cut off part of the EGFR once it has bound its ligand, freeing the ligand to go and stimulate another cell^[1]. Therapeutic ADAM inhibitors can potentiate anti-cancer therapy^{[citation needed]}.

It is categorized under EC 3.4.24.46.

Types include:

• ADAMTS2
• ADAMTS13
• ADAMTS5
• ADAM17

References

External links

• MeSH ADAM+Proteins
• http://www.healthvalue.net/sheddase.html

Template:Biochemistry-stub

v • d • e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM protein	ADAMTS2 - ADAMTS13 - ADAMTS5 - ADAM17 - Alpha secretase
Matrix metalloproteinase	Collagenase - Gelatinase
Other	Neprilysin - Procollagen peptidase - Thermolysin - Pregnancy-associated plasma protein A - Bone morphogenetic protein 1 - Insulysin - Lysostaphin

v • d • e Protein: glycoproteins

Activin - ADAM protein - Alpha 1-antichymotrypsin - Apolipoprotein H - CD70 - Asialoglycoprotein - Avidin - B-cell activating factor - 4-1BB ligand - Cholesterylester transfer protein - Clusterin - Colony-stimulating factor - Haemopexin - Inhibin - Lactoferrin - Membrane glycoproteins - Mucoprotein - Myelin protein zero - Osteonectin - Protein C - Protein S - Proteoglycan - Serum Amyloid P component - Sialoglycoprotein (CD43, Glycophorin, Glycophorin C) - Thrombopoietin - Thyroglobulin - Thyroxine-binding proteins - Transcortin - Tumor necrosis factor-alpha - Uteroglobin - Vitronectin

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .