Blue rubber bleb nevus syndrome natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Common complications of blue rubber bleb nevus syndrome include GI bleeding, Intussusception, and Intestinal perforation.
Natural History, Complications and Prognosis
Natural History
- The symptoms of blue rubber bleb nevus syndrome usually develop in the first decade of life, and start with symptoms such as [1]
Complications
Common complications of blue rubber bleb nevus syndrome include:[2][3][4][5]
- Acute GI bleeding[6]
- Anemia due to bleeding[7]
- Intussusception
- Bowel infarction
- Intestinal torsion
- Necrosis of intestinal mucosa
- Intestinal perforation
- Volvulus
- Stroke
- Abscess formation and
- Even death due to central nervous system involvement.[8]
Prognosis
- Depending on the extent of the blue rubber bleb nevus syndrome at the time of diagnosis, the prognosis may vary.
- Prognosis of the blue rubber bleb nevus syndrome is depend on the following:[9][10]
- Severity of the signs and symptoms at the time of diagnosis
- Vascular malformations size and number
- Vascular malformations locations
- Overall, prognosis is good and patients with blue rubber bleb nevus syndrome have normal lifespan if it diagnosed intime.[11]
References
- ↑ Rodrigues D, Bourroul ML, Ferrer AP, Monteiro Neto H, Gonçalves ME, Cardoso SR (2000). "Blue rubber bleb nevus syndrome". Rev Hosp Clin Fac Med Sao Paulo. 55 (1): 29–34. PMID 10881076.
- ↑ Dwivedi M, Misra SP (2002). "Blue rubber bleb nevus syndrome causing upper GI hemorrhage: a novel management approach and review". Gastrointestinal Endoscopy. 55 (7): 943–6. PMID 12024162. Retrieved 2012-09-10. Unknown parameter
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ignored (help) - ↑ Nahm WK, Moise S, Eichenfield LF, Paller AS, Nathanson L, Malicki DM, Friedlander SF (May 2004). "Venous malformations in blue rubber bleb nevus syndrome: variable onset of presentation". J. Am. Acad. Dermatol. 50 (5 Suppl): S101–6. doi:10.1016/S0190. PMID 15097941.
- ↑ Jin XL, Wang ZH, Xiao XB, Huang LS, Zhao XY (December 2014). "Blue rubber bleb nevus syndrome: a case report and literature review". World J. Gastroenterol. 20 (45): 17254–9. doi:10.3748/wjg.v20.i45.17254. PMID 25493043.
- ↑ Feingold RM (2009). "The blue rubber bleb [corrected] nevus syndrome". J Insur Med. 41 (1): 67–71. PMID 19518008.
- ↑ Dobru D, Seuchea N, Dorin M, Careianu V (September 2004). "Blue rubber bleb nevus syndrome: case report and literature review". Rom J Gastroenterol. 13 (3): 237–40. PMID 15470538.
- ↑ Lybecker MB, Stawowy M, Clausen N (December 2016). "Blue rubber bleb naevus syndrome: a rare cause of chronic occult blood loss and iron deficiency anaemia". BMJ Case Rep. 2016. doi:10.1136/bcr-2016-216963. PMID 27999128.
- ↑ Tomelleri G, Cappellari M, Di Matteo A, Zanoni T, Colato C, Bovi P, Moretto G (August 2010). "Blue rubber bleb nevus syndrome with late onset of central nervous system symptomatic involvement". Neurol. Sci. 31 (4): 501–4. doi:10.1007/s10072-010-0250-4. PMID 20352269.
- ↑ Jin, Xue-Li (2014). "Blue rubber bleb nevus syndrome: A case report and literature review". World Journal of Gastroenterology. 20 (45): 17254. doi:10.3748/wjg.v20.i45.17254. ISSN 1007-9327.
- ↑ Apak H, Celkan T, Ozkan A, Yildiz I, Aydemir EH, Ozdil S, Kuruoglu S (2004). "Blue rubber bleb nevus syndrome associated with consumption coagulopathy: treatment with interferon". Dermatology (Basel). 208 (4): 345–8. doi:10.1159/000077846. PMID 15178920.
- ↑ Hernandez, Oscar V.; Blancas, Manuel; Paz, Victor; Moran, Segundo; Hernandez, Luisa (2007). "DIAGNOSIS AND TREATMENT OF BLUE RUBBER BLEB NEVUS SYNDROME WITH DOUBLE BALLOON ENTEROSCOPY AND ENDOSCOPIC ULTRASOUND". Digestive Endoscopy. 19 (2): 86–89. doi:10.1111/j.1443-1661.2007.00672.x. ISSN 0915-5635.