Blue rubber bleb nevus syndrome

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Blue rubber bleb nevus syndrome Classification and external resources
ICD-10	D18.
ICD-9	228.0
ICD-O:	9121/0
eMedicine	derm/56

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Overview

Blue rubber bleb nevus syndrome (or "BRBNS", or "blue rubber bleb syndrome, or "blue rubber-bleb nevus", or "Bean syndrome") is a rare disorder that consists mainly of abnormal blood vessels affecting the gastrointestinal tract.

Presentation

BRBNS is a venous malformation, formerly, though incorrectly, thought to be related to the hemangioma. It carries significant potential for serious or fatal bleeding. Lesions are most commonly found on the skin and in the small intestine and distal large bowel.

Causes

The causes of this syndrome are unknown. Not more than a few hundred cases have been described worldwide.

History

It was first described by Gascoyen in 1860.^[1] In 1958 William Bennett Bean described the lesions further and came up with the term BRBNS, chosen because the 'cutaneous hemangiomas have the look and feel of rubber nipples'.^[1]

References

Additional Resources

• Moodley M, Ramdial P (1993). "Blue rubber bleb nevus syndrome: case report and review of the literature". Pediatrics 92 (1): 160-2. PMID 8516068
• Dobru D, Seuchea N, Dorin M, Careianu V (2004). "Blue rubber bleb nevus syndrome: case report and literature review". Rom J Gastroenterol 13 (3): 237-40. PMID 15470538
• Dwivedi M, Misra SP (2002). "Blue rubber bleb nevus syndrome causing upper GI hemorrhage: a novel management approach and review". Gastrointest Endosc 55 (7): 943-6. PMID 12024162

External links

• Birthmarks.us
• DermAtlas 216
• Miami Herald article describing day in the life of a sufferer

v • d • e Soft tissue tumors and sarcomas (ICD-O 8800-9349)
Not otherwise specified (8800-8809)	Soft tissue sarcoma - Desmoplastic small round cell tumor
Fibromatous (8810-8839)	Fibroma/fibrosarcoma - Malignant fibrous histiocytoma - Dermatofibroma/dermatofibrosarcoma - Dermatofibrosarcoma protuberans
Myxomatous (8840-8849)	Myxoma - Ossifying fibromyxoid tumour
Lipomatous (8850-8889)	Lipoma/liposarcoma (Angiomyolipoma)
Myomatous (8890-8929)	Leiomyoma/leiomyosarcoma - Myoma - Rhabdomyoma/rhabdomyosarcoma - Sarcoma botryoides
Complex Mixed And Stromal (8930-8999)	Adenomyoma - Pleomorphic adenoma - Mixed Mullerian tumor - Mesoblastic nephroma - Wilms' tumor - Rhabdoid tumour - Clear cell sarcoma of the kidney - Hepatoblastoma - Carcinosarcoma
Fibroepithelial (9000-9039)	Brenner tumour - Fibroadenoma - Phyllodes tumor
Synovial-like (9040-9049)	Synovial sarcoma - Clear cell sarcoma, NOS
Mesothelial (9050-9059)	Mesothelioma - Adenomatoid tumor
Germ cell tumors (9060-9119)	germinomatous germ cell tumors: Dysgerminoma - Germinoma - Seminoma nongerminomatous germ cell tumors: Embryonal carcinoma - Endodermal sinus tumor / Yolk sac tumor - Teratoma/Fetus in fetu / Dermoid cyst/Struma ovarii - Gestational trophoblastic disease (Hydatidiform mole) - Choriocarcinoma - Polyembryoma - Gonadoblastoma
Vascular (9120-9179)	blood vessels: Hemangioma/hemangiosarcoma - Angioma/angiosarcoma - Blue rubber bleb nevus syndrome - Hemangioendothelioma - Kaposi's sarcoma - Hemangiopericytoma lymphatic vessels: Lymphangioma/lymphangiosarcoma - Lymphangioleiomyomatosis
Osseous and chondromatous (9180-9349)	Osteoma/osteosarcoma - Osteochondroma - Chondroma/enchondroma/chondrosarcoma - Chondroblastoma - Giant cell tumor of bone - Ewing's sarcoma - Chordoma teeth/odontogenic: (Cementoblastoma, Cementoma, Odontoma, Adenomatoid odontogenic tumor, Ameloblastoma) Adamantinoma

v • d • e WikiDoc Research Resources for Blue rubber bleb nevus syndrome (Click show to right to view)
Articles on Blue rubber bleb nevus syndrome	Most recent articles on Blue rubber bleb nevus syndrome • Most cited articles on Blue rubber bleb nevus syndrome • Review articles on Blue rubber bleb nevus syndrome • Articles on Blue rubber bleb nevus syndrome in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Blue rubber bleb nevus syndrome	Powerpoint slides on Blue rubber bleb nevus syndrome • Images of Blue rubber bleb nevus syndrome • Photos of Blue rubber bleb nevus syndrome • Podcasts & MP3s on Blue rubber bleb nevus syndrome • Videos on Blue rubber bleb nevus syndrome
Evidence Based Medicine Regarding Blue rubber bleb nevus syndrome	Cochrane Collaboration on Blue rubber bleb nevus syndrome • Bandolier on Blue rubber bleb nevus syndrome • TRIP on Blue rubber bleb nevus syndrome
Cost Effectiveness of Blue rubber bleb nevus syndrome	Cost Effectiveness of Blue rubber bleb nevus syndrome
Clinical Trials Involving Blue rubber bleb nevus syndrome	Ongoing Trials on Blue rubber bleb nevus syndrome at Clinical Trials.gov • Trial results on Blue rubber bleb nevus syndrome • Clinical Trials on Blue rubber bleb nevus syndrome at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Blue rubber bleb nevus syndrome	US National Guidelines Clearinghouse on Blue rubber bleb nevus syndrome • NICE Guidance on Blue rubber bleb nevus syndrome • NHS PRODIGY Guidance • FDA on Blue rubber bleb nevus syndrome • CDC on Blue rubber bleb nevus syndrome
Textbook Information on Blue rubber bleb nevus syndrome	Books and Textbook Information on Blue rubber bleb nevus syndrome
Pharmacology Resources on Blue rubber bleb nevus syndrome	Dosing of Blue rubber bleb nevus syndrome • Drug interactions with Blue rubber bleb nevus syndrome • Side effects of Blue rubber bleb nevus syndrome • Allergic reactions to Blue rubber bleb nevus syndrome • Overdose information on Blue rubber bleb nevus syndrome • Carcinogenicity information on Blue rubber bleb nevus syndrome • Blue rubber bleb nevus syndrome in pregnancy • Pharmacokinetics of Blue rubber bleb nevus syndrome •
Genetics, Pharmacogenomics, and Proteinomics of Blue rubber bleb nevus syndrome	Genetics of Blue rubber bleb nevus syndrome • Pharmacogenomics of Blue rubber bleb nevus syndrome • Proteomics of Blue rubber bleb nevus syndrome
Newstories on Blue rubber bleb nevus syndrome	Blue rubber bleb nevus syndrome in the news • Be alerted to news on Blue rubber bleb nevus syndrome • News trends on Blue rubber bleb nevus syndrome
Commentary on Blue rubber bleb nevus syndrome	Blogs on Blue rubber bleb nevus syndrome
Patient Resources on Blue rubber bleb nevus syndrome	Patient resources on Blue rubber bleb nevus syndrome • Discussion groups on Blue rubber bleb nevus syndrome • Patient Handouts on Blue rubber bleb nevus syndrome • Directions to Hospitals Treating Blue rubber bleb nevus syndrome • Risk calculators and risk factors for Blue rubber bleb nevus syndrome
Healthcare Provider Resources on Blue rubber bleb nevus syndrome	Symptoms of Blue rubber bleb nevus syndrome • Causes & Risk Factors for Blue rubber bleb nevus syndrome • Diagnostic studies for Blue rubber bleb nevus syndrome • Treatment of Blue rubber bleb nevus syndrome
Continuing Medical Education (CME) Programs on Blue rubber bleb nevus syndrome	CME Programs on Blue rubber bleb nevus syndrome
International Resources on Blue rubber bleb nevus syndrome	Blue rubber bleb nevus syndrome en Espanol • Blue rubber bleb nevus syndrome en Francais
Business Resources on Blue rubber bleb nevus syndrome	Blue rubber bleb nevus syndrome in the Marketplace • Patents on Blue rubber bleb nevus syndrome
Informatics Resources on Blue rubber bleb nevus syndrome	List of terms related to Blue rubber bleb nevus syndrome

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .