Anhedonia medical therapy

Jump to: navigation, search

Anhedonia Microchapters

Home

Patient Information

Overview

Historical Perspective

Pathophysiology

Causes

Epidemiology and Demographics

Risk Factors

Diagnosis

Diagnostic Criteria

History and Symptoms

Treatment

Medical Therapy

Primary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Anhedonia On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Anhedonia

CDC on Anhedonia

Anhedonia in the news

Blogs on Anhedonia

Directions to Hospitals Treating Anhedonia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]

Overview

Anhedonia is an important symptom in many psychiatric illness. Currently there is no available specific treatment for it. More studies need to be done to explore this territory.

Treatment

There is no validated treatment for social anhedonia.[1]

  • Social support may play a valuable role in the treatment of social anhedonia Blanchard et al.(2011) A greater number of social support as well as a greater perceived social support network were related to fewer schizophrenia-spectrum symptoms and to better general functioning within the social anhedonia group. [2]

Future research should focus on genetic and environmental risk factors to home in on specific brain regions and neurotransmitters that may be implicated in the social anhedonia etiology and could be targeted with specialized pharmacological or behavioral treatments.

  • Agomelatine was pitteed against venlafaxine in a study to treat anhedonia. Former showed greater improvements on CGI scores. In vivo agomelatine increases dopamine levels in nucleus accumbens of reward system.[3][4]
  • Atypical neuroleptics is less effective on dopaminergic motivation system, so schizophrenic patient tends to perform better. Drugs acting on an opioid, serotonin, and glutamine effective on anhedonia.[5]
  • Pramipraxole has shown promise to tackle anhedonia in parkinsonism.[6]

References

  1. Horan, W. P., Kring, A. M., & Blanchard, J. J. (2006). Anhedonia in schizophrenia: a review of assessment strategies. Schizophrenia bulletin, 32(2), 259–273
  2. Blanchard, J.J., Collins, L.M., Aghevli, M., Leung, W.W. & Cohen, A.S. (2011). Social anhedonia and schizotypy in a community sample: the Maryland longitudinal study of schizotypy. Schizophrenia Bulletin, 37, 587-602
  3. "Agomelatine versus venlafaxine XR in ... [J Clin Psychopharmacol. 2012] - PubMed - NCBI".
  4. "Notes on the treatment of anhedonia. [Can Psychiatr Assoc J. 1978] - PubMed - NCBI".
  5. "Anhedonia is an important factor of health-r... [J Nerv Ment Dis. 2011] - PubMed - NCBI".
  6. "Anhedonia, depression, and m... [J Neuropsychiatry Clin Neurosci. 2005] - PubMed - NCBI".



Linked-in.jpg