Anhedonia cost-effectiveness of therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]

Overview

Anhedonia seems to be an important factor influencing prognosis of many diseases. Few studies have shown reduced positive outcome and increased rate of complication in the presence of anhedonia.

Cost-Effectiveness of Therapy

Schizophrenia

  • Elevated levels of social anhedonia in patients with schizophrenia have been linked to poorer social functioning.[1][2]
  • Socially anhedonic individuals perform worse on a number of neuropsychological tests than non-anhedonic participants,[3][4] and show similar physiological abnormalities seen in patients with schizophrenia.[5]

Cardiac Diseases

  • Anhedonia is associated with an increase in all-cause mortality in patients who survived the first 6 months post-PCI.[6]
  • Reduced compliance to medication regiment

Anhedonia itself, rather than other criteria of major depressive disorder significantly worsen outcomes in post-ACS patients . Understanding it's mechanism may help to novel treatment modalities to improve post-ACS outcomes.[7]

Addiction

  • Anhedonia increase likelihood of addiction cravings and relapse. It seems to be a stronger predictor of relapse in the patients with the history of major depressive disorder.[8] More studies on anhedonia is needed, to find out novel treatments for addiction.[9]

References

  1. Blanchard, J.J., Bellack, A.S., & Mueser, K.T. (1994).
    • Affective and social-behavioral correlates of physical and social anhedonia in schizophrenia. ‘’Journal of Abnormal Psychology, 103’’, 719-728.
  2. Blanchard, J.J., Mueser, K.T., & Bellack, A.S. (i1998). Anhedonia, positive and negative affect, and social functioning in schizophrenia. ‘’Schizophrenia Bulletin, 24’’, 413–424.
  3. Laurent, A., Biloa-Tang, M., Bougerol, T., Duly, D., Anchisi, A.M., Bosson, J.L., Pellat, J., d’Amato, T., & Dalery, J. (2000).
    • Executive/ attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives. ‘’Schizophrenia Research, 46’’, 269–283.
  4. Cohen, A., Leung, W., Saperstein, A., & Blanchard, J. (2006). Neuropsychological functioning and social anhedonia: Results from a community high-risk study. ‘’Schizophrenia Research, 85’’, 132−141.
  5. Cohen, A.S., Leung, W.W., Saperstein, A.M., & Blanchard, J.J. (2006). Neuropsychological functioning and social anhedonia: results from a community high-risk study. ‘’Schizophrenia Research, 85’’, 132-141.
  6. "http://cpr.sagepub.com/content/20/1/127.abstract". External link in |title= (help)
  7. "Anhedonia Predicts Major Adverse Cardiac Events and Mortality in Patients 1 Year After Acute Coronary Syndrome".
  8. "Effects of anhedonia on days to relapse amo... [Nicotine Tob Res. 2010] - PubMed - NCBI".
  9. "Anhedonia in substance use disorders: A systematic review of its nature, course and clinical correlates".



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