Ameloblastoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S[2], Simrat Sarai, M.D. [3]

Overview

In several cases, the patients with ameloblastoma are asymptomatic. Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.

Natural History, Complications, and Prognosis

Natural History

  • Ameloblastoma is regarded as a true neoplasm of enamel.
  • Ameloblastoma described as unicentric, nonfunctional, intermittent in growth.
  • Ameloblastoma is the second most common odontogenic neoplasm.
  • Ameloblastoma histologically classified as six subtypes:
    • Follicular subtype
    • Plexiform subtype
    • Acanthomatous subtype
    • Granular subtype
    • Desmoplastic subtype and
    • Basilar subtype.

Complications

Prognosis

  • The prognosis of ameloblastoma was determined mainly by the method of surgical treatment, which means that patients receiving a radical treatment had a better prognosis than those who received a radical one. [6][7]
  • In more than 50% patients receiving the conservative treatment had good prognosis without any recurrence.
  • Ameloblastoma which has a well-defined edge with sclerosis is thought to grow slowly, and the normal bone has a strong reaction to form the sclerosis edge, and the prognosis is good.
  • Ameloblastomawith the ill-defined radiographic boundary, the tumor has the highest proliferative ability and poorest prognosis.
  • Radical surgery should be used for the multicystic ameloblastoma to prevent the recurrence.
  • The follicular ameloblastoma were thought to have a higher recurrence rate than unicystic or plexiform.[8]

References

  1. Gümgüm S, Hoşgören B (2005). "Clinical and radiologic behaviour of ameloblastoma in 4 cases". J Can Dent Assoc. 71 (7): 481–4. PMID 16026635.
  2. Morgan, Peter R. (2011). "Odontogenic tumors: a review". Periodontology 2000. 57 (1): 160–76. doi:10.1111/j.1600-0757.2011.00393.x. ISSN 0906-6713.
  3. Ruslin, M; Hendra, FN; Vojdani, A; Hardjosantoso, D; Gazali, M; Tajrin, A; Wolff, J; Forouzanfar, T (2017). "The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study". Medicina Oral Patología Oral y Cirugia Bucal: 0–0. doi:10.4317/medoral.22185. ISSN 1698-6946.
  4. Ruslin, M; Hendra, FN; Vojdani, A; Hardjosantoso, D; Gazali, M; Tajrin, A; Wolff, J; Forouzanfar, T (2017). "The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study". Medicina Oral Patología Oral y Cirugia Bucal: 0–0. doi:10.4317/medoral.22185. ISSN 1698-6946.
  5. Mukhopadhyay S, Raha K, Mondal SC (July 2005). "Huge ameloblastoma of jaw-A case report". Indian J Otolaryngol Head Neck Surg. 57 (3): 247–8. doi:10.1007/BF03008023. PMC 3451340. PMID 23120181.
  6. Ruslin, M; Hendra, FN; Vojdani, A; Hardjosantoso, D; Gazali, M; Tajrin, A; Wolff, J; Forouzanfar, T (2017). "The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study". Medicina Oral Patología Oral y Cirugia Bucal: 0–0. doi:10.4317/medoral.22185. ISSN 1698-6946.
  7. Mukhopadhyay S, Raha K, Mondal SC (July 2005). "Huge ameloblastoma of jaw-A case report". Indian J Otolaryngol Head Neck Surg. 57 (3): 247–8. doi:10.1007/BF03008023. PMC 3451340. PMID 23120181.
  8. Li, Yi; Han, Bo; Li, Long-Jiang (2012). "Prognostic and proliferative evaluation of ameloblastoma based on radiographic boundary". International Journal of Oral Science. 4 (1): 30–33. doi:10.1038/ijos.2012.8. ISSN 1674-2818.

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