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| {{SI}} | | {{Varicose veins}} |
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| {{CMG}}
| | '''For patient information, click [[Varicose veins (patient information)|here]]''' |
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| {{SK}} Varicosities; venous insufficiency; phlebectasia | | {{CMG}}; {{AE}} {{Ochuko}}; {{Sapan}};{{Lovepreet Randhawa}} |
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| ==Overview==
| | {{SK}} Varicosities; phlebectasia |
| '''Varicose veins''' are veins that have become enlarged and twisted. The term commonly refers to the veins on the leg, although varicose veins occur [[varices|elsewhere]]. Veins have leaflet valves to prevent blood from flowing backwards (retrograde). Leg muscles pump the veins to return blood to the heart. When veins become enlarged, the leaflets of the valves no longer meet properly, and the valves don't work. A common cause of valve failure is Deep Vein Thrombosis (DVT), which can cause permanent damage to the valves. The blood collects in the veins and they enlarge even more. Varicose veins are common in the superficial veins of the legs, which are subject to high pressure when standing. Besides cosmetic problems, varicose veins are often painful, especially when standing or walking. They often itch, and scratching them can cause ulcers. Serious complications are rare. Non-surgical treatments include [[sclerotherapy]], elastic stockings, elevating the legs, and exercise. The traditional surgical treatment has been [[vein stripping]] to remove the affected veins. Newer surgical treatments are less invasive (see [[radiofrequency ablation]]) and are slowly replacing traditional surgical treatments. Since most of the blood in the legs is returned by the deep veins, and the superficial veins only return about 10%, they can be removed or ablated without serious harm.<ref>Merck Manual Home Edition, 2nd ed.[http://www.merck.com/mmhe/sec03/ch036/ch036d.html] </ref>
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| ==Causes== | | ==[[Varicose veins overview|Overview]]== |
| Varicose veins are more common in women than in men, and are linked with [[heredity]]<ref>{{cite journal | author = Ng M, Andrew T, Spector T, Jeffery S | title = Linkage to the [[FOXC2]] region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. | journal = J Med Genet | volume = 42 | issue = 3 | pages = 235-9 | year = 2005 | id = PMID 15744037}}</ref>. Other related factors are [[pregnancy]], [[obesity]], [[menopause]], [[Senescence|aging]], prolonged standing, leg injury and abdominal straining. Varicose veins are bulging veins that are larger than spider veins, typically 3 mm or more in diameter.<ref>NHS Direct[http://www.nhsdirect.nhs.uk/articles/article.aspx?articleId=387§ionId=28131] </ref> Varicose veins are distinguished from reticular veins (blue veins) and [[spider_veins|telangiectasias]] (spider veins) which also involve valvular insufficiency,<ref>Weiss R A, Weiss M A, Doppler Ultrasound Findings in Reticular Veins of the Thigh Subdermic Lateral Venous System and Implications for Sclerotherapy, Journal of Derm Surg Onc, Vol 19 No 10 (Oct 1993) p947-951.</ref> by the size and location of the veins.
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| ==Symptoms== | | ==[[Varicose veins historical perspective|Historical Perspective]]== |
| * Aching, heavy legs (often worse at night and after exercise)
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| * Ankle swelling
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| * A brownish-blue shiny skin discoloration around the veins
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| * Skin over the vein may become dry, itchy and thin, leading to [[eczema]] (venous eczema)
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| * The skin may darken ([[stasis dermatitis]]), because of the waste products building up in the legs
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| * Minor injuries to the area may bleed more than normal and/or take a long time to heal
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| * Rarely, there is a large amount of bleeding from a ruptured vein
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| * In some people the skin above the ankle may shrink (lipodermatosclerosis) because the fat underneath the skin becomes hard.
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| * [[Restless Leg Syndrome]]<ref>Schul M., McDonagh B., Guptan R.C. (2005). "High Prevalence Of Restless Leg syndrome In Patients With Chronic Venous Insufficiency." [http://www.veinclinics.com/5research_6.html RLS & varicose veins]</ref>. Restless Leg Syndrome appears to be a common overlapping clinical syndrome in patients with varicose veins and other chronic venous insufficiency.
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| <div align="left">
| | ==[[Varicose veins classification|Classification]]== |
| <gallery heights="175" widths="175">
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| Image:Varicose veins.jpg|Varicose veins <br> (Image courtesy of Charlie Goldberg, M.D., UCSD School of Medicine and VA Medical Center, San Diego, CA)
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| </gallery>
| | ==[[Varicose veins pathophysiology|Pathophysiology]]== |
| </div>
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| ==Treatment== | | ==[[Varicose veins causes|Causes]]== |
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| ===Conservative treatment=== | | ==[[Varicose veins differential diagnosis|Differentiating Varicose veins from other Diseases]]== |
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| The symptoms of varicose veins can be controlled to an extent with the following:
| | ==[[Varicose veins epidemiology and demographics|Epidemiology and Demographics]]== |
| *Elevating the legs often provides temporary symptomatic relief.
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| *"Advice about regular exercise sounds sensible but is not supported by any evidence."<ref>BMJ 2006;333:287-292 (5 August), Varicose veins and their management, Bruce Campbell [http://www.bmj.com/cgi/content/full/333/7562/287 (subscription)]</ref>
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| *The wearing of graduated [[compression stockings]] with a pressure of 30–40 mmHg has been shown to correct the swelling, nutritional exchange, and improve the microcirculation in legs affected by varicose veins.<ref>Curri SB et al. Changes of cutaneous microcirculation from elasto-compression in chronic venous insufficiency. In Davy A and Stemmer R, editors: Phlebology '89, Montrouge, France, 1989, John Libbey Eurotext.</ref> They also often provide relief from the discomfort associated with this disease. Caution should be exercised in their use in patients with concurrent arterial disease.
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| The symptoms of varicose veins can be controlled to an extent with either of the following:
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| *Anti-inflammatory medication such as [[ibuprofen]] or [[aspirin]] can be used as part of treatment for superficial thrombophlebitis along with graduated compression hosiery – but there is a risk of intestinal bleeding. In extensive superficial thrombophlebitis, consideration should be given to anti-coagulation, thrombectomy or sclerotherapy of the involved vein.
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| *[[Diosmin 95]] is a dietary supplement distributed in the U.S. by Nutratech, Inc. The U.S. Food and Drug Administration does not approve dietary supplements, and concluded that there was an "inadequate basis for reasonable expectation of safety." <ref>New Dietary Ingredients in Dietary Supplements, U. S. Food and Drug Administration
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| Center for Food Safety and Applied Nutrition
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| Office of Nutritional Products, Labeling, and Dietary Supplements
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| February 2001 (Updated September 10, 2001), http://www.cfsan.fda.gov/~dms/ds-ingrd.html</ref> <ref>Memorandum
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| [http://www.fda.gov/ohrms/dockets/dockets/95s0316/rpt0083_01.pdf]</ref>
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| <div align="left">
| | ==[[Varicose veins risk factors|Risk Factors]]== |
| <gallery heights="175" widths="175">
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| Image:Dornst_venengym.jpg|Vein gymnastics.
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| </gallery>
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| </div>
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| ===Surgical treatment=== | | ==[[Varicose veins screening|Screening]]== |
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| Several techniques have been performed for over a century, from the more invasive named "saphenous stripping" up to mini invasives like superficial phlectomies and CHIVA cure.
| | ==[[Varicose veins natural history, complications and prognosis|Natural History, Complications and Prognosis]]== |
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| ====Stripping==== | | ==Diagnosis== |
| | | [[Varicose veins history and symptoms| History and Symptoms]] | [[Varicose veins physical examination | Physical Examination]] | [[Varicose veins laboratory findings|Laboratory Findings]] | [[Varicose veins CT|CT]] | [[Varicose veins MRI|MRI]] | [[Varicose veins ultrasound|Ultrasound]] | [[Varicose veins other imaging findings|Other Imaging Findings]] | [[Varicose veins other diagnostic studies|Other Diagnostic Studies]] |
| Stripping consists in a removal of all the saphena vein main trunk from the groin down to the ankle.The complications include deep vein thrombosis (5.3%),<ref>van Rij AM et al. Incidence of Deep Venous Thrombosis after Varicose Vein Surgery, Br J Surg 2004 Dec;91(12):1582-5</ref> pulmonary embolism (0.06%), and wound complications including infection (2.2%). For traditional surgery, reported recurrence rates, which have been tracked for 10 years, range from 5-60%. In addition, since stripping removes the saphenous main trunks, they are no longer availlable for venous by-pass in the future (coronary and/or leg artery vital disease)<ref>Hammarsten J, Pedersen P, Cederlund CG, Campanello M.
| | ==Treatment== |
| Department of Surgery and Radiology, Hospital of Varberg, Sweden
| | [[Varicose veins medical therapy|Medical Therapy]] | [[Varicose veins surgery|Surgery]] | [[Varicose veins primary prevention|Primary Prevention]] | [[Varicose veins secondary prevention|Secondary Prevention]] | [[Varicose veins cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Varicose veins future or investigational therapies|Future or Investigational Therapies]] |
| Long saphenous vein saving surgery for varicose veins. A long-term follow-up. Eur J Vasc Surg. 1990 Aug;4(4):361-4.
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| </ref>
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| ====CHIVA==== | |
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| CHIVA is the acronym for Conservative and Haemodynamic cure of Incompetent Varicose veins in Ambulatory patients translated from the French cure "Conservatrice et Hémodynamique de l'Insuffisance Veineuse en Ambulatoire"<ref>claude Franceschi, Cure CHIVA, 1988, Editions de L'Armançon, 21390 Precy-Sous-Thil France</ref> published in France in 1988.
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| ;Pathophysiological principles
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| CHIVA relies on an hemodynamic impairment assessed by data and evidences depicted through Ultrasound dynamic venous investigations. According to this new concept, the clinical symptoms of venous insufficiency are not the cause but the consequence of various abnormalities of the venous system. For example,a varicose vein being overloaded, may be dilated not only because of valvular incompetence (the most frequent) but because of a venous block (thombosis) or arterio-venous fistulae...and so the treatment has to be tailord according the hemodynamic feature.
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| ;Procedure and outcomes
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| It generally consists in 1 to 4 small incisions under local anaestesia in order to disconnect the varicose veins from the abnormal flow due to valvular incompetence which dilates them.<ref>[http://www.dailymotion.com/3d4050d0c5d14ae36f61e4639/video/9617821]</ref> The patient is dismissed the same day. This method leads to an improvement of the venous function in order to:
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| * Cure the symptoms of venous insufficiency as varicose veins, legs swelling, ulcers.<ref>Maeso and all, Comparision of clinical outcome of Stripping and CHIVA for Treatment of varicose veins in Lower Extremities, Ann Vasc Surg 2001; 15: 661-665 </ref><ref>"
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| Zamboni and all: Minimally Invasive Surgical management of primary Venous Ulcers vs Compression Treatment: a randomized Clinical Trial. Eur J Vasc Endovsc Surg 00,1-6 (2003)</ref><br />
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| * Prevent varicose recurrence due to progressive enlargement of collateral veins which replace and overtake the destroyed veins: CHIVA vs Stripping: varicose recurrence divided by 2 to 5 at 10 years.<ref>Varicose Vein Stripping vs. Haemodynamic Correction
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| (C.H.I.V.A.): a Long Term Randomised Trial
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| S. Carandina and all; Eur J Vasc Endovasc Surg xx, 1e8 (2007)
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| doi:10.1016/j.ejvs.2007.09.011, online http://www.sciencedirect.com</ref>
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| * Preserve the superficial venous capital for unpredictable but possible need for coronary or leg artery vital by-pass which increases with ageing.
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| ;Consequences
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| To be achieved properly,CHIVA method needs a comprehensive knowledge of both hemodynamics and Ultrasound venous investigation.
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| ===Non-surgical treatment===
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| ====Sclerotherapy==== | | ==Case Studies== |
| | [[Varicose veins case study one|Case #1]] |
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| A commonly performed non-surgical treatment for varicose and "spider" leg veins is [[sclerotherapy]]. It has been used in the treatment of varicose veins for over 150 years.<ref>Goldman M, Sclerotherapy Treatment of varicose and telangiectatic leg vein, Hardcover Text, 2nd Ed, 1995</ref> Sclerotherapy is often used for telangiectasias (spider veins) and varicose veins that persist or recur after vein stripping.<ref>"Veins & Lymphatics," L. K. Pak et al, ''in'' Lange's Current Surgical Diagnosis & Treatment, 11th ed., McGraw-Hill, </ref><ref>Tisi PV, Beverley C, Rees A. Injection sclerotherapy for varicose veins. Cochrane Database of Systematic Reviews 2006, Issue 4. Art. No.: CD001732.</ref>
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| Sclerotherapy can also be performed using microfoam sclerosants under ultrasound guidance to treat larger varicose veins, including the greater and short saphenous veins.<ref>Paul Thibault, Sclerotherapy and Ultrasound-Guided Sclerotherapy, The Vein Book / editor, John J. Bergan, 2007.</ref><ref>Padbury A, Benveniste G L, Foam echosclerotherapy of the small saphenous vein, Australian and New Zealand Journal of Phlebology Vol 8, Number 1 (December 2004)</ref> A study by Kanter and Thibault in 1996 reported a 76% success rate at 24 months in treating saphenofemoral junction and great saphenous vein incompetence with STS 3% solution.<ref>Kanter A, Thibault P. Saphenofemoral junction incompetence treated by ultrasound-guided sclerotherapy, Dermatol Surg. 1996. 22: 648-652.</ref> A Cochrane Collaboration review<ref>http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001732/abstract.html</ref> concluded sclerotherapy was better than surgery in the short term (1 year) for its treatment success, complication rate and cost, but surgery was better after 5 years, although the research is weak.<ref>Rigby KA, Palfreyman SJ, Beverley C, Michaels JA. Surgery versus sclerotherapy for the treatment of varicose veins. Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD004980. [http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD004980/abstract.html]</ref>
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| A Health Technology Assessment found that sclerotherapy provided less benefit than surgery, but is likely to provide a small benefit in varicose veins without reflux.<ref>Michaels JA, Campbell WB, Brazier JE, MacIntyre JB, Palfreyman SJ, Ratcliffe J, et al. Randomized clinical trial, observational study and assessment of cost-effectiveness of the treatment of varicose veins (REACTIV trial). Health Technol Assess 2006;10(13). [http://www.hta.ac.uk/fullmono/mon1013.pdf] This Health Technology Assessment monograph includes reviews of the epidemiology, assessment, and treatment of varicose veins, as well as a study on clinical and cost effectiveness of surgery and sclerotherapy</ref> Complications of sclerotherapy are rare but can include blood clots and ulceration. [[Anaphylaxis|Anaphylactic]] reactions are "extraordinarily rare but can be life-threatening," and doctors should have resuscitation equipment ready.<ref>William R. Finkelmeier, Sclerotherapy, Ch. 12, ACS Surgery: Principles & Practice, 2004, WebMD (hardcover book)</ref> There has been one reported case of stroke after ultrasound guided sclerotherapy when an unusually large dose of sclerosant foam was injected.
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| ====Endovenous laser and radiofrequency ablation====
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| The Australian Medical Services Advisory Committee (MSAC) in 2008 has determined that endovenous laser treatment for varicose veins "appears to be more effective in the short term, and at least as effective overall, as the comparative procedure of junction ligation and vein stripping for the treatment of varicose veins."<ref>Medical Services Advisory Committee, Endovenous laser therapy (ELT) for varicose veins. MSAC application 1113, Dept of Health and Ageing, Commonwealth of Australia, 2008. http://www.msac.gov.au/internet/msac/publishing.nsf/Content/2E0BACBB8704139ACA25745E001C2F21/$File/1113report.pdf</ref> It also found in its assessment of available literature, that "occurrence rates of more severe complications such as DVT, nerve injury and paraesthesia, post-operative infections and haematomas, appears to be greater after ligation and stripping than after EVLT". Complications for endovenous laser treatment include minor skin burns (0.4%)<ref name="Elmore"> Elmore FA and Lackey D, Effectiveness of laser treatment in eliminating superficial venous reflux, Phlebology 2008 :23 :21-31</ref> and temporary paraesthesia (2.1%).<ref name="Elmore"/> The longest study of endovenous laser ablation is 39 months.
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:000 1486.jpg|Varicose veins after [[EVLT]]
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| </gallery>
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| </div>
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| Two prospective randomized trials found speedier recovery and fewer complications after radiofrequency obliteration (AKA radiofrequency ablation) compared to open surgery.<ref>Rautio, T, et al., Endovenous oblitration versus conventional stripping operation in the treatment of primary varicose veins, J Vasc Surg 2002:35:958-65</ref><ref>Lurie F, et al., Prospective randomized study of endovenous radiofrequency oblitration (closure) versus ligation and vein stripping (EVOLVeS: two-year follow-up. Eur J Vasc Endovasc Surg 2005;29:67-73</ref> Myers<ref>Kenneth Myers, An opinion —surgery for small saphenous reflux is obsolete!" Australian and New Zealand Journal of Phlebology, Vol 8, Number 1 (December 2004)</ref> wrote that open surgery for [[small saphenous vein]] reflux is obsolete. Myers said these veins should be treated with endovenous techniques, citing high recurrence rates after surgical management, and risk of nerve damage up to 15%. In comparison, radiofrequency ablation has been shown to control 80% of cases of small saphenous vein reflux at 4 years, said Myers. Complications for radiofrequency ablation include burns, paraesthesia, clinical phlebitis, and slightly higher rates of deep vein thrombosis (0.57%) and pulmonary embolism (0.17%).One 3-year study compared radiofrequency, with a recurrence rate of 33%, to open surgery, which had a recurrence rate of 23%.
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| Endovenous laser and radiofrequency ablation require specialized training for doctors and expensive equipment. Endovenous laser treatment is performed as an outpatient procedure and does not require the use of an operating theatre, nor does the patient need a general anaesthetic. Doctors must use ultrasound during the procedure to see what they are doing. Some practitioners also perform phlebectomy or ultrasound guided sclerotherapy at the time of endovenous treatment. Follow-up treatment to smaller branch varicose veins is often needed in the weeks after the initial procedure.
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| ===Other treatments are:===
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| *[[ambulatory phlebectomy]]
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| *laser vein removal
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| *vein ligation
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| ==Complications==
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| Most varicose veins are relatively benign, but severe varicosities can lead to major complications, due to the poor circulation through the affected limb.
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| * Pain, heaviness, inability to walk or stand for long hours thus hindering work
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| * Skin conditions / [[Dermatitis]] which could predispose skin loss
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| * Bleeding : life threatening bleed from injury to the varicose vein
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| * [[Ulcer]] : non healing varicose ulcer could threaten limb amputation.
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| * Development of carcinoma or sarcoma in longstanding venous ulcers. There have been over 100 reported cases of malignant transformation and the rate is reported as 0.4% to 1%.<ref>Goldman M. Sclerotherapy, Treatment of Varicose and Telangiectatic Leg Veins. Hardcover Text, 2nd Ed, 1995</ref>
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| * Coagulation of blood in varicose veins cause superficial thrombosis, [[deep vein thrombosis|deep vein thrombosis (DVT)]], [[Pulmonary Embolism]] (PE) & could precipitate [[stroke]] in the rare case of predisposed individuals (that is, patients with [[patent foramen ovale]]).
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| ==External links==
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| * [http://www.venousresearchfoundation.com/index.asp Varicose Veins and varicosities ]
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| * [http://www.postgradmed.com/issues/1999/09_99/pn_veins.htm Varicose Vein overview]
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| * [http://www.nhsdirect.nhs.uk/en.aspx?articleId=387 NHS Direct - Varicose Veins]
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| * [http://www.vascularweb.org/_CONTRIBUTION_PAGES/Patient_Information/NorthPoint/Varicose_Veins.html Varicose Veins] Society for Vascular Surgery patient pages. Good illustrations.
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| * [http://www.phlebology.com.au/forms/selmenu.aspx?selmenu=5 Varicose Vein Treatment in Australasia] Information from the Australasian College of Phlebology Website
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| *[http://cvdforum.veinclinics.com Venous disease forum] Blog for physicians to collaborate on vein disease treatment
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| *[http:////www.wikisurgery.com/index.php?title=Varicose-veins-Operationscript Varicose veins: Operation Script on Wikisurgery].
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| *[http://www.wikisurgery.com/index.php?title=Varicose-veins-day-case-Patientinformation Varicose veins: Information for patients on Wikisurgery]
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| ==References==
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| {{Reflist|2}}
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| {{Circulatory system pathology}} | | {{Circulatory system pathology}} |
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