Transitional cell carcinoma classification: Difference between revisions
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{{Transitional cell carcinoma}} | {{Transitional cell carcinoma}} | ||
{{CMG}} | {{CMG}};{{AE}} {{PSK}} {{RG}} | ||
==Overview== | ==Overview== | ||
Based on the growth pattern, transitional cell | Based on the growth pattern, [[transitional cell carcinoma]] may be classified into either papillary [[urothelial carcinoma]] or non-papillary [[urothelial carcinoma]]. [[Transitional cell carcinoma]] may be classified according to [[World Health Organization]] in a collaborative effort conjointly with the [[International Society of Urological Pathologists]] (ISUP) into two groups: infiltrating [[Urothelial carcinoma|urothelial carcinomas]] and non-invasive [[urothelial carcinoma]]<nowiki/>s.Based on the degree of [[cellular differentiation]][[Transitional cell carcinoma|, transitional cell carcinoma]] may be classified into two grades: low [[Grading (tumors)|grade]] and high [[Grading (tumors)|grade.]] | ||
==Classification== | ==Classification== | ||
Based on the growth pattern, transitional cell | Based on the growth pattern, transitional cell carcinoma may be classified into two subtypes:<ref name="LederDunnick1990">{{cite journal|last1=Leder|first1=R A|last2=Dunnick|first2=N R|title=Transitional cell carcinoma of the pelvicalices and ureter.|journal=American Journal of Roentgenology|volume=155|issue=4|year=1990|pages=713–722|issn=0361-803X|doi=10.2214/ajr.155.4.2119098}}</ref> | ||
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Papillary urothelial carcinoma | Papillary urothelial carcinoma | ||
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*Slim finger-like projections that grow from the lining of the renal pelvis or ureter into the cavity | *Slim finger-like projections that grow from the lining of the [[renal pelvis]] or [[ureter]] into the cavity | ||
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*Sessile or nodular tumors | *Sessile or nodular tumors | ||
*They grow deeper into the layers of the wall of the renal pelvis or ureter rather than into its cavity | *They grow deeper into the layers of the wall of the [[renal pelvis]] or [[ureter]] rather than into its cavity | ||
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===WHO Classification=== | ===WHO Classification=== | ||
Transitional cell carcinomas may be classified according to World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) into two groups: infiltrating urothelial carcinomas and non-invasive urothelial carcinomas:<ref name="pmid12461053">{{cite journal| author=Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F| title=Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems. | journal=J Clin Pathol | year= 2002 | volume= 55 | issue= 12 | pages= 900-5 | pmid=12461053 | doi= | pmc=PMC1769816 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12461053}}</ref> | Transitional cell carcinomas may be classified according to [[World Health Organization]] in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) into two groups: infiltrating urothelial carcinomas and non-invasive urothelial carcinomas:<ref name="pmid12461053">{{cite journal| author=Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F| title=Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems. | journal=J Clin Pathol | year= 2002 | volume= 55 | issue= 12 | pages= 900-5 | pmid=12461053 | doi= | pmc=PMC1769816 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12461053 }} </ref> | ||
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{{familytree | | | | | B02 | B02= <div style="float: left; text-align: left; width: 30em; padding:1em;">'''Non-invasive urothelial carcinoma''' | {{familytree | | | | | B02 | B02= <div style="float: left; text-align: left; width: 30em; padding:1em;">'''Non-invasive urothelial carcinoma''' | ||
:*Urothelial carcinoma in situ | :*Urothelial [[carcinoma in situ]] | ||
:*High grade papillary urothelial carcinoma | :*High grade papillary urothelial carcinoma | ||
:*Low grade papillary urothelial carcinoma | :*Low grade papillary urothelial carcinoma | ||
:*Non-invasive papillary urothelial neoplasm of low malignant potential | :*Non-invasive papillary urothelial neoplasm of low [[malignant]] potential | ||
:*Urothelial papilloma | :*Urothelial [[papilloma]] | ||
:*Inverted urothelial papilloma | :*Inverted urothelial papilloma | ||
</div>}} | </div>}} | ||
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===Grading=== | ===Grading=== | ||
According to the WHO grading criteria, there are two grades of transitional cell carcinoma based on the degree of cellular differentiation: | According to the [[WHO]] grading criteria, there are two grades of transitional cell carcinoma based on the degree of [[cellular differentiation]]: | ||
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*Tumors with the least degree of cellular anaplasia | *Tumors with the least degree of cellular anaplasia | ||
*Rarely invades the muscular wall of the bladder or spreads to other parts of the body | *Rarely invades the muscular wall of the bladder or spreads to other parts of the body | ||
*Often recurs | *Often recurs after treatment | ||
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High grade | High grade | ||
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*Tumors with the most severe degrees of cellular anaplasia | *Tumors with the most severe degrees of cellular [[anaplasia]] | ||
*Commonly recurs and also has a strong tendency to invade the muscular wall of the bladder and spread to other parts of the body | *Commonly recurs and also has a strong tendency to invade the muscular wall of the [[bladder]] and spread to other parts of the body | ||
*High grade transitional cell carcinoma is much more likely to result in death | *High grade transitional cell carcinoma is much more likely to result in death | ||
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[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
Latest revision as of 03:30, 30 October 2019
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Transitional cell carcinoma Microchapters |
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Differentiating Transitional cell carcinoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Transitional cell carcinoma classification On the Web |
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American Roentgen Ray Society Images of Transitional cell carcinoma classification |
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Directions to Hospitals Treating Transitional cell carcinoma |
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Risk calculators and risk factors for Transitional cell carcinoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2] Ramyar Ghandriz MD[3]
Overview
Based on the growth pattern, transitional cell carcinoma may be classified into either papillary urothelial carcinoma or non-papillary urothelial carcinoma. Transitional cell carcinoma may be classified according to World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) into two groups: infiltrating urothelial carcinomas and non-invasive urothelial carcinomas.Based on the degree of cellular differentiation, transitional cell carcinoma may be classified into two grades: low grade and high grade.
Classification
Based on the growth pattern, transitional cell carcinoma may be classified into two subtypes:[1]
| Type | Description |
|---|---|
|
Papillary urothelial carcinoma |
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Non-papillary urothelial carcinoma |
|
WHO Classification
Transitional cell carcinomas may be classified according to World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) into two groups: infiltrating urothelial carcinomas and non-invasive urothelial carcinomas:[2]
| Transitional cell tumors | |||||||||||||||
Infiltrating urothelial carcinoma
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Non-invasive urothelial carcinoma
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Grading
According to the WHO grading criteria, there are two grades of transitional cell carcinoma based on the degree of cellular differentiation:
| Grade | Description |
|---|---|
|
Low grade |
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High grade |
References
- ↑ Leder, R A; Dunnick, N R (1990). "Transitional cell carcinoma of the pelvicalices and ureter". American Journal of Roentgenology. 155 (4): 713–722. doi:10.2214/ajr.155.4.2119098. ISSN 0361-803X.
- ↑ Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F (2002). "Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems". J Clin Pathol. 55 (12): 900–5. PMC 1769816. PMID 12461053.