Transitional cell carcinoma epidemiology and demographics
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Among transitional cell carcinomas, upper urinary tract transitional cell carcinomas are rare cancers accounting for 5-7% of all transitional cell cancer cases. The incidence of upper urinary tract transitional cell carcinoma was estimated to be 0.6-1.1 cases per 100,000 individuals in the United States. Transitional cell carcinoma commonly affects individuals older than 60 years of age with the average age of presentation being 65. Males are more commonly affected with transitional cell carcinoma than females. The male to female ratio is approximately 2 to 1.
Epidemiology and Demographics
- Transitional cell carcinomas of upper urinary tract are rare cancers accounting for 5-7% of all transitional cell cancer cases.
- Transitional cell carcinoma of the renal pelvis, accounts for only 7% of all kidney tumors.
- Transitional cell cancer of the ureter, accounts for only 1 of every 25 upper tract tumors.
- Bladder cancer is the ninth most common cancer in the world, with 430,000 new cases diagnosed in 2012.
- In the United States, approximately 80,000 new cases and 18,000 deaths occur each year due to bladder cancer.
- In developed regions such as North America and Europe, bladder cancer is predominantly urothelial.
- From 1985 to 2005, the number of bladder cancers diagnosed in the United States increased by over 50 percent, while from 1975 to 1996 the five-year survival rate for those diagnosed with bladder cancer increased from 75 to 81 percent.
- Transitional cancer is typically diagnosed in older individuals, with a median age at diagnosis of 69 years in men and 71 in women.
- Transitional cell carcinoma of the urinary bladder is rare in young adults, as less than 1% of such tumors present in the first 4 decades of life.
- In the United States, white males have the highest risk with roughly twice the incidence seen in African American and Hispanic men.
- Males are more commonly affected with transitional cell carcinoma than females. The male to female ratio is approximately 2 to 1.
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