Thrombotic thrombocytopenic purpura diagnostic study of choice: Difference between revisions

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== Overview ==
== Overview ==
== Study of choice ==
== Study of choice ==
* '''ADAMTS13 test:'''
'''Studies that may be considered for diagnosis of the suspected cases of TTP:'''
* Complete blood count (CBC) with platelet count
* Complete blood count (CBC) with platelet count
* Review of the peripheral blood smear
* Review of the peripheral blood smear
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{{#Widget:PLASMIC score}}
{{#Widget:PLASMIC score}}
<br>
<br>
'''<big>Risk of ADAMPTS13 deficiency</big>'''  '''<big>in adults with suspected TTP</big>''' <ref name="JammeRondeau2017">{{cite journal|last1=Jamme|first1=Matthieu|last2=Rondeau|first2=Eric|title=The PLASMIC score for thrombotic thrombocytopenic purpura|journal=The Lancet Haematology|volume=4|issue=4|year=2017|pages=e148–e149|issn=23523026|doi=10.1016/S2352-3026(17)30024-8}}</ref>'''<big>:</big>'''
'''<big>Risk of ADAMPTS13 deficiency</big>'''  '''<big>in adults with suspected TTP</big>''' '''<big>:</big>'''
* '''Low-risk''' = 0 to 4 points  
* '''Low-risk''' = 0 to 4 points  
* '''Intermediate risk''' = 5 points
* '''Intermediate risk''' = 5 points
* '''High-risk''' = 6 to 7 points
* '''High-risk''' = 6 to 7 points
==References==
==References==
<references />

Revision as of 22:09, 24 August 2018

Thrombotic thrombocytopenic purpura Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Saeedeh Kowsarnia M.D.[2]

Overview

Study of choice

  • ADAMTS13 test:

Studies that may be considered for diagnosis of the suspected cases of TTP:

  • Complete blood count (CBC) with platelet count
  • Review of the peripheral blood smear
  • Serum electrolytes and creatinine
  • Serum lactate dehydrogenase (LDH)
  • Serum bilirubin level
  • Coagulation testing ( PT, aPTT, fibrinogen, D-dimer)
  • Serum haptoglobin level
  • Direct antiglobulin (Coombs) test (DAT)
  • ADAMTS13 activity and inhibitor testing
  • Stool exam


PLASMIC score

Platelet count (< 30,000/microL)
Hemolysis variables (Retic count > 2.5%, undetectable haptoglobin, indirect billi <2 mg/dL( >34 mcmol/L))
Absence of active cancer
Absence of transplant history (solid, stem cell)
MCV < 90 Fl
INR < 1.5
Serum creatinine < 2 mg/dL (<177 mcmol/L)
Score:

Risk of ADAMPTS13 deficiency in adults with suspected TTP :

  • Low-risk = 0 to 4 points
  • Intermediate risk = 5 points
  • High-risk = 6 to 7 points

References