Syndrome of inappropriate antidiuretic hormone pathophysiology

Revision as of 17:23, 15 November 2017 by Skazmi (talk | contribs)
Jump to navigation Jump to search

Syndrome of inappropriate antidiuretic hormone Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differential Diagnosis

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Syndrome of inappropriate antidiuretic hormone pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Syndrome of inappropriate antidiuretic hormone pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Syndrome of inappropriate antidiuretic hormone pathophysiology

CDC on Syndrome of inappropriate antidiuretic hormone pathophysiology

Syndrome of inappropriate antidiuretic hormone pathophysiology in the news

Blogs on Syndrome of inappropriate antidiuretic hormone pathophysiology

Directions to Hospitals Treating Syndrome of inappropriate antidiuretic hormone

Risk calculators and risk factors for Syndrome of inappropriate antidiuretic hormone pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]

Overview

Syndrome of inappropriate antidiuretic hormone production is a condition in which the body develops an excess of water and a decrease in the concentration of electrolytes. SIADH may be caused by a central nervous system diseases, cancers, pulmonary diseases, or some drugs.

Pathophysiology

The normal function of antidiuretic hormone (ADH) on the kidneys is to control the amount of water reabsorbed by kidney nephrons. ADH acts in the distal portion of the renal tubule (distal convoluted tubule) as well as on the collecting duct and causes the retention of water. Owing to the water retention, dilution of the blood and hyponatremia occurs.

Pathogenesis

https://youtu.be/MR8BABoFTP8}}

Feedback inhibition

  • In general, the plasma sodium concentration is the primary osmotic determinant of AVP release. In SIADH, there is non physiological secretion of AVP. There is enhanced water reabsorption, leading to dilutional hyponatremia.

Genetics

Associated conditions

Gross pathology

There are no gross pathology findings associated with SIADH, however SIADH may be associated with squamous cell carcinoma of the lung, which exhibits the following gross pathology findings:

Microscopic pathology

There are no microscopic findings associated with SIADH, however SIADH may be associated with squamous cell carcinoma of the lung, which exhibits the following microscopic pathology findings:

References

  1. Pillai BP, Unnikrishnan AG, Pavithran PV (2011). "Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder". Indian J Endocrinol Metab. 15 Suppl 3: S208–15. doi:10.4103/2230-8210.84870. PMC 3183532. PMID 22029026.


Template:WikiDoc Sources