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{{Swine influenza}}
{{Swine influenza}}'''For more information about seasonal human influenza virus that is not associated with animal exposure, see [[Influenza]]'''<br><br>
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{{CMG}}; {{AE}} {{YD}}


==Differentiating Swine influenza from other Diseases==
==Overview==
Swine influenza should be differentiated from the following diseases or pathogens that cause [[upper respiratory tract infection|upper]] or [[lower respiratory tract infection]] or [[flu-like illness]], such as other [[influenza virus]]es, such as [[human influenza|human]] or [[swine influenza]], other viral, bacterial, fungal, and parasitic agents that are typically associated with [[nasopharyngeal infection|nasopharyngeal]] and [[respiratory tract infection]]s, and non-infectious causes, such as [[asthma]], [[chronic obstructive pulmonary disease]] (COPD), [[drug adverse effects]], and [[cardiac]] causes.


Clinicians should consider swine influenza A (H1N1) virus infection in the differential diagnosis of patients with febrile respiratory disease and who :
==Differential Diagnosis==
Influenza should be differentiated from the following diseases or pathogens that cause upper or lower respiratory disease or flu-like symptoms:<ref name="SzewczukThapa2010">{{cite journal|last1=Szewczuk|first1=Elektra|last2=Thapa|first2=Kiran|last3=Anninos|first3=Terry|last4=McPhie|first4=Kenneth|last5=Higgins|first5=Geoff|last6=Dwyer|first6=Dominic E|last7=Stanley|first7=Keith K|last8=Iredell|first8=Jonathan R|title=Rapid semi-automated quantitative multiplex tandem PCR (MT-PCR) assays for the differential diagnosis of influenza-like illness|journal=BMC Infectious Diseases|volume=10|issue=1|year=2010|pages=113|issn=1471-2334|doi=10.1186/1471-2334-10-113}}</ref><ref name="LiuSchulze2010">{{cite journal|last1=Liu|first1=Ding Xiang|last2=Schulze|first2=Martin|last3=Nitsche|first3=Andreas|last4=Schweiger|first4=Brunhilde|last5=Biere|first5=Barbara|title=Diagnostic Approach for the Differentiation of the Pandemic Influenza A(H1N1)v Virus from Recent Human Influenza Viruses by Real-Time PCR|journal=PLoS ONE|volume=5|issue=4|year=2010|pages=e9966|issn=1932-6203|doi=10.1371/journal.pone.0009966}}</ref>
===Infectious Diseases===
* Other influenza viruses, such as human influenza or avian influenza
*Other infectious agents, including viruses, bacteria, fungi, and parasites, that are typically responsible for respiratory illness
** [[Anthrax]] (caused by ''B. anthracis'')
** [[Arenaviruses]]
** [[Cytomegalovirus]] (CMV)
**[[Chlamydia pneumoniae]]
** [[Coronaviruses]] (responsible for [[SARS]] and [[MERS]])
** [[Dengue fever]]
** [[Echovirus]]es
** [[Ebola]] virus infection
** [[Hantavirus pulmonary syndrome]]
** [[Herpes]] viruses
** [[HIV]] disease
** [[Histoplasmosis]] and other fungal causes of respiratory disease
** [[Human metapneumovirus]]
** [[Malaria]]
** [[Measles]]
** [[Parainfluenza virus]]
** [[Poliovirus]] infection
** [[Q fever]]
** [[Rhinovirus]]
** [[Respiratory syncytial virus]]
** Other bacterial causes of nasopharyngeal and respiratory infection, such as ''S. pneumoniae'', ''S. aureus'', ''H. influenzae'', ''M. pneumoniae'', ''M. tuberculosis'', ''L. pneumophila''.


* live in areas in the U.S. with confirmed human cases of swine influenza A (H1N1) virus infection or
===Non-infectious Diseases===
* [[Asthma]]
* [[Bronchiectasis]]
* [[Chronic obstructive pulmonary disease]] and [[emphysema]]
* Drugs, such as [[interferon]]s, [[monoclonal antibodies]], [[bisphosphonate]]s, and [[chemotherapeutic agent]]s
* [[Hematologic malignancies]] ([[leukemia]]s and [[lymphoma]]s)
* [[Myocarditis]]
* [[Metal fume fever]]
* [[Pericarditis]]
* [[Pulmonary embolism]]
* [[Vaccination]]s (typically transient and mild flu-like illness)


* traveled recently to Mexico or were in contact with persons who had febrile respiratory illness and were in the areas of the U.S. with confirmed swine influenza cases or Mexico in the 7 days preceding their illness onset.
==Differentiating Flu and Common Cold==
{| style="border: 0px; font-size: 85%; margin: 3px; width:500px;" align=center
|valign=top|
|+
! style="background: #4479BA; color:#FFF;  width: 150px;" | Symptoms
! style="background: #4479BA; color:#FFF;  width: 200px;" | Flu
! style="background: #4479BA; color:#FFF;  width: 200px;" | Common Cold
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |  Fever
| style="padding: 5px 5px; background: #F5F5F5;" | High fever (100-102° F)
| style="padding: 5px 5px; background: #F5F5F5;" | Rare
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |  Headache
| style="padding: 5px 5px; background: #F5F5F5;" | Common
| style="padding: 5px 5px; background: #F5F5F5;" | Rare
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |  Cough
| style="padding: 5px 5px; background: #F5F5F5;" | Common, moderate to severe
| style="padding: 5px 5px; background: #F5F5F5;" | Mild to moderate
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | Body aches
| style="padding: 5px 5px; background: #F5F5F5;" | Common, may be severe
| style="padding: 5px 5px; background: #F5F5F5;" | Slight
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | Fatigue
| style="padding: 5px 5px; background: #F5F5F5;" | Usual, can last up to 2-3 weeks
| style="padding: 5px 5px; background: #F5F5F5;" | Sometimes
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | Nasal congestion
| style="padding: 5px 5px; background: #F5F5F5;" | Sometimes
| style="padding: 5px 5px; background: #F5F5F5;" | Common
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | Sneezing
| style="padding: 5px 5px; background: #F5F5F5;" | Sometimes
| style="padding: 5px 5px; background: #F5F5F5;" | Common
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | Sore throat
| style="padding: 5px 5px; background: #F5F5F5;" | Sometimes
| style="padding: 5px 5px; background: #F5F5F5;" | Common
|-
| style="padding: 0px 5px; background: #F5F5F5;" colspan=3| <small>Adapted from the National Institute of Allergy and Infectious Diseases (NIAID) <ref>{{cite web|url=http://www.niaid.nih.gov/topics/Flu/understandingFlu/Pages/overview.aspx |title=National Institute of Allergy and Infectious Diseases (NIAID)- Flu (Influenza)}}</ref></small>
|}


==References==
==References==
{{reflist|2}}


[[Category:Infectious disease]]
{{Reflist|2}}
[[Category:Disease]]
[[Category:Pandemics]]
[[Category:Influenza]]
[[Category:Infectious diseases]]
[[Category:Medicine]]
[[Category:Virology]]
[[Category:Microbiology]]
[[Category:Pulmonology]]
[[Category:Occupational safety and health]]
{{WH}}
{{WS}}

Revision as of 22:07, 21 February 2016

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For more information about seasonal human influenza virus that is not associated with animal exposure, see Influenza

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.

Overview

Swine influenza should be differentiated from the following diseases or pathogens that cause upper or lower respiratory tract infection or flu-like illness, such as other influenza viruses, such as human or swine influenza, other viral, bacterial, fungal, and parasitic agents that are typically associated with nasopharyngeal and respiratory tract infections, and non-infectious causes, such as asthma, chronic obstructive pulmonary disease (COPD), drug adverse effects, and cardiac causes.

Differential Diagnosis

Influenza should be differentiated from the following diseases or pathogens that cause upper or lower respiratory disease or flu-like symptoms:[1][2]

Infectious Diseases

Non-infectious Diseases

Differentiating Flu and Common Cold

Symptoms Flu Common Cold
Fever High fever (100-102° F) Rare
Headache Common Rare
Cough Common, moderate to severe Mild to moderate
Body aches Common, may be severe Slight
Fatigue Usual, can last up to 2-3 weeks Sometimes
Nasal congestion Sometimes Common
Sneezing Sometimes Common
Sore throat Sometimes Common
Adapted from the National Institute of Allergy and Infectious Diseases (NIAID) [3]

References

  1. Szewczuk, Elektra; Thapa, Kiran; Anninos, Terry; McPhie, Kenneth; Higgins, Geoff; Dwyer, Dominic E; Stanley, Keith K; Iredell, Jonathan R (2010). "Rapid semi-automated quantitative multiplex tandem PCR (MT-PCR) assays for the differential diagnosis of influenza-like illness". BMC Infectious Diseases. 10 (1): 113. doi:10.1186/1471-2334-10-113. ISSN 1471-2334.
  2. Liu, Ding Xiang; Schulze, Martin; Nitsche, Andreas; Schweiger, Brunhilde; Biere, Barbara (2010). "Diagnostic Approach for the Differentiation of the Pandemic Influenza A(H1N1)v Virus from Recent Human Influenza Viruses by Real-Time PCR". PLoS ONE. 5 (4): e9966. doi:10.1371/journal.pone.0009966. ISSN 1932-6203.
  3. "National Institute of Allergy and Infectious Diseases (NIAID)- Flu (Influenza)".

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