SUZ12: Difference between revisions

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This zinc finger gene has been identified at the breakpoints of a recurrent [[chromosomal translocation]] reported in endometrial stromal sarcoma. [[Genetic recombination|Recombination]] of these breakpoints results in the fusion of this gene and [[JAZF1]]. The protein encoded by this gene contains a zinc finger domain in the [[C terminus]] of the coding region. The specific function of this gene has not yet been determined.<ref name="entrez" />
This zinc finger gene has been identified at the breakpoints of a recurrent [[chromosomal translocation]] reported in endometrial stromal sarcoma. [[Genetic recombination|Recombination]] of these breakpoints results in the fusion of this gene and [[JAZF1]]. The protein encoded by this gene contains a zinc finger domain in the [[C terminus]] of the coding region. The specific function of this gene has not yet been determined.<ref name="entrez" />


SUZ12, as part of Polycomb Repressive Complex 2 ([[PRC2]]), may be involved with chromatin silencing in conjunction with [[HOTAIR]] ncRNA, using its [[zinc-finger]] domain to bind the RNA molecule.<ref name="Rinn">{{cite journal | vauthors = Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY | title = Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs | journal = Cell | volume = 129 | issue = 7 | pages = 1311–23 | date = June 2007 | pmid = 17604720 | pmc = 2084369 | doi = 10.1016/j.cell.2007.05.022 }}</ref>
SUZ12, as part of Polycomb Repressive Complex 2 ([[PRC2]]), may be involved with chromatin silencing in conjunction with [[HOTAIR]] ncRNA, using its [[zinc-finger]] domain to bind the RNA molecule.<ref name="Rinn">{{cite journal | vauthors = Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY | title = Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs | journal = Cell | volume = 129 | issue = 7 | pages = 1311–23 | date = June 2007 | pmid = 17604720 | pmc = 2084369 | doi = 10.1016/j.cell.2007.05.022 |authorlink11=Howard Y. Chang}}</ref>


== References ==
== References ==
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* {{cite journal | vauthors = Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K | title = Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity | journal = The EMBO Journal | volume = 23 | issue = 20 | pages = 4061–71 | date = October 2004 | pmid = 15385962 | pmc = 524339 | doi = 10.1038/sj.emboj.7600402 }}
* {{cite journal | vauthors = Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K | title = Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity | journal = The EMBO Journal | volume = 23 | issue = 20 | pages = 4061–71 | date = October 2004 | pmid = 15385962 | pmc = 524339 | doi = 10.1038/sj.emboj.7600402 }}
* {{cite journal | vauthors = Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC | title = Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3 | journal = Science | volume = 310 | issue = 5746 | pages = 306–10 | date = October 2005 | pmid = 16224021 | doi = 10.1126/science.1118947 }}
* {{cite journal | vauthors = Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC | title = Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3 | journal = Science | volume = 310 | issue = 5746 | pages = 306–10 | date = October 2005 | pmid = 16224021 | doi = 10.1126/science.1118947 }}
* {{cite journal | vauthors = Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA | title = Control of developmental regulators by Polycomb in human embryonic stem cells | journal = Cell | volume = 125 | issue = 2 | pages = 301–13 | date = April 2006 | pmid = 16630818 | doi = 10.1016/j.cell.2006.02.043 }}
* {{cite journal | vauthors = Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA | title = Control of developmental regulators by Polycomb in human embryonic stem cells | journal = Cell | volume = 125 | issue = 2 | pages = 301–13 | date = April 2006 | pmid = 16630818 | doi = 10.1016/j.cell.2006.02.043 | pmc=3773330}}
* {{cite journal | vauthors = Furuno K, Masatsugu T, Sonoda M, Sasazuki T, Yamamoto K | title = Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro | journal = Biochemical and Biophysical Research Communications | volume = 345 | issue = 3 | pages = 1051–8 | date = July 2006 | pmid = 16712789 | doi = 10.1016/j.bbrc.2006.05.014 }}
* {{cite journal | vauthors = Furuno K, Masatsugu T, Sonoda M, Sasazuki T, Yamamoto K | title = Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro | journal = Biochemical and Biophysical Research Communications | volume = 345 | issue = 3 | pages = 1051–8 | date = July 2006 | pmid = 16712789 | doi = 10.1016/j.bbrc.2006.05.014 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}

Latest revision as of 18:37, 27 July 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.[1][2][3][4]

Function

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.[4]

SUZ12, as part of Polycomb Repressive Complex 2 (PRC2), may be involved with chromatin silencing in conjunction with HOTAIR ncRNA, using its zinc-finger domain to bind the RNA molecule.[5]

References

  1. Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
  2. Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J (May 2001). "Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors". Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6348–53. doi:10.1073/pnas.101132598. PMC 33471. PMID 11371647.
  3. Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB (December 2008). "Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development". Reproduction. 136 (6): 777–85. doi:10.1530/REP-08-0045. PMID 18784248.
  4. 4.0 4.1 "Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)".
  5. Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY (June 2007). "Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs". Cell. 129 (7): 1311–23. doi:10.1016/j.cell.2007.05.022. PMC 2084369. PMID 17604720.

Further reading

External links