Rimantadine: Difference between revisions

Revision as of 19:44, 6 January 2014

Rimantadine
Flumadine^® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Rimantadine (INN, sold under the trade name Flumadine) is an orally administered antiviral drugused to treat, and in rare cases prevent, Influenzavirus A infection. When taken within one to two days of developing symptoms, rimantadine can shorten the duration and moderate the severity of influenza. It is a derivate of adamantane, like a similar drug amantadine. It was approved by the Food and Drug Administration (FDA) in 1994.

US Brand Names

Flumadine^®

FDA Package Insert

Mechanism of Action

References

@@ Line 1: / Line 1: @@
-{{drugbox
-| IUPAC_name = 1-(1-adamantyl)ethanamine
-| image = Rimantadine.png
-| width = 84
-| CAS_number = 13392-28-4
-| ATC_prefix = J05
-| ATC_suffix = AC02
-| PubChem = 5071
-| DrugBank = APRD01219
-| C = 12 |H = 21 |N = 1
-| molecular_weight = 179.302 [[Gram|g]]/[[Mole (unit)|mol]]
-| bioavailability = well absorbed
-| protein_bound = 40%
-| metabolism = [[Liver|Hepatic]] [[hydroxylation]] and [[glucuronidation]]
-| elimination_half-life = 25.4 ± 6.3 hours
-| excretion = [[Kidney|Renal]]
-| pregnancy_category = C <small>([[United States|U.S.]])</small>
-| legal_status = ℞-only <small>(U.S.)</small>
-| routes_of_administration = Oral
-}}
-{{SI}}
 __NOTOC__
+{{Rimantadine}}
+{{CMG}}
+==Overview==
+'''Rimantadine''' ([[International Nonproprietary Name|INN]], sold under the trade name '''Flumadine''') is an orally administered [[antiviral drug]]used to treat, and in rare cases prevent, [[Influenzavirus A]] infection.  When taken within one to two days of developing symptoms, rimantadine can shorten the duration and moderate the severity of influenza. It is a derivate of [[adamantane]], like a similar drug [[amantadine]]. It was approved by the [[Food and Drug Administration]] (FDA) in 1994.
-'''For patient information, please click [[Rimantadine (patient information)|here]]'''
+==Category==
+Antiviral
+==US Brand Names==
+Flumadine<sup>®</sup>
+==FDA Package Insert==
-'''Rimantadine''' ([[International Nonproprietary Name|INN]], sold under the trade name '''Flumadine''') is an orally administered [[antiviral drug]] used to treat, and in rare cases prevent, [[Influenzavirus A]] infection.  When taken within one to two days of developing symptoms, rimantadine can shorten the duration and moderate the severity of influenza. It is a derivate of [[adamantane]], like a similar drug [[amantadine]]. It was approved by the [[Food and Drug Administration]] (FDA) in 1994.
+'''  [[Rimantadine description|Description]]'''
+'''| [[Rimantadine clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[Rimantadine microbiology|Microbiology]]'''
+'''| [[Rimantadine indications and usage|Indications and Usage]]'''
+'''| [[Rimantadine contraindications|Contraindications]]'''
+'''| [[Rimantadine warnings and precautions|Warnings and Precautions]]'''
+'''| [[Rimantadine adverse reactions|Adverse Reactions]]'''
+'''| [[Rimantadine drug interactions|Drug Interactions]]'''
+'''| [[Rimantadine overdosage|Overdosage]]'''
+'''| [[Rimantadine clinical studies|Clinical Studies]]'''
+'''| [[Rimantadine dosage and administration|Dosage and Administration]]'''
+'''| [[Rimantadine how supplied|How Supplied]]'''
+'''| [[Rimantadine labels and packages|Labels and Packages]]'''
-==Mechanics==
+==Mechanism of Action==
-Scientists do not understand why rimantadine works, but believe it inhibits influenza's [[Virus#Viral replication|viral replication]], possibly by preventing the uncoating of the virus's protective shells, which are the [[Virus#Viral structure|envelope and capsid]].  Genetic studies suggest that the virus [[M2 protein]], an [[ion channel]] specified by virion M2 [[gene]], plays an important role in the susceptibility of influenza A virus to inhibition by rimantadine. Resistance to rimantadine can occur as a result of an amino acid substitutions at certain locations in the transmembrane region of M2. This prevents binding of the antiviral to the channel.
+==References==
+{{Reflist|2}}
-==Drug interactions==
+[[Category:Antiviral]]
+[[Category:Wikinfect]]
-Taking [[acetaminophen]] ([[Tylenol]]) or [[aspirin]] while taking rimantadine is known to reduce the body's uptake of rimantadine by approximately 12%.[http://www.fda.gov/cder/drug/antivirals/influenza/flumadine.htm] [[Cimetidine]] also affects the body's uptake of rimantadine.
-==Adverse effects==
-Rimantadine can produce [[gastrointestinal]] and [[central nervous system]] [[Adverse effect (medicine)|adverse effects]].  Studies have shown it produces fewer side effects than other anti-viral influenza treatments.  Approximately 6% of patients (compared to 6% of patients taking a placebo) reported side effects.[http://www.cdc.gov/flu/professionals/treatment/side-effects.htm] Common side effects include:
-*[[nausea]]
-*upset stomach
-*nervousness
-*tiredness
-*lightheadedness
-*trouble sleeping
-*difficulty concentrating
-==Other Uses==
-Rimantadine, like its antiviral cousin [[amantadine]], possesses some NMDA antagonistic properties and is used as an antiparkinsonic drug (ie, in the treatment of [[Parkinson's Disease]]).  However, neither rimantadine nor amantadine are preferred agents for this therapy and are generally reserved for cases of the disease which are less responsive to front-line treatments.
-==External links==
-*[http://www.fda.gov/bbs/topics/ANSWERS/ANS00530.html U.S. FDA press release announcing rimantadine's approval]
-*[http://www.fda.gov/cder/drug/antivirals/influenza/flumadine.htm U.S. Center for Drug Evaluation and Research rimantadine description]
-*[http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a698029.html U.S. NIH rimantadine description]
-*[http://www.cdc.gov/flu/professionals/treatment/index.htm U.S. CDC flu anti-viral treatment information]
-{{Antivirals}}
-{{Influenza}}
-[[es:Rimantadina]]
-[[fr:Rimantadine]]
-[[th:ไรแมนตาดีน]]
-[[zh:金刚乙胺]]
-{{WikiDoc Help Menu}}
-{{WikiDoc Sources}}
-[[Category:Anti-influenza agents]]
-[[Category:Influenza]]
-[[Category:Infectious disease]]