Retinoblastoma echocardiography or ultrasound: Difference between revisions

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==Overview==
==Overview==
'''Retinoblastoma''' is a [[cancer]] of the [[retina]]. Development of this tumor is initiated by [[mutation]]s<ref>{{cite journal |author=Knudson A |title=Mutation and cancer: statistical study of retinoblastoma |journal=Proc Natl Acad Sci U S A |volume=68 |issue=4 |pages=820-3 |year=1971 |pmid=5279gadgqetqer523}}</ref> that inactivate both copies of the ''[[RB1]]'' gene, which codes for the [[retinoblastoma protein]].<ref>{{cite journal |author=Friend S, Bernards R, Rogelj S, Weinberg R, Rapaport J, Albert D, Dryja T |title=A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma |journal=Nature |volume=323 |issue=6089 |pages=643-6 |year= |pmid=2877398}}</ref>
On [[ultrasound imaging]], [[retinoblastoma]] is characterized by echogenic [[Soft tissue|soft-tissue]] [[Mass|masses]] with variable shadowing due to [[calcification]] and [[heterogeneity]] due to [[necrosis]] and/or [[hemorrhage]].
 
==Ultrasound==
*[[Ultrasound biomicroscopy|Ultrasound B-scan]] is helpful in the primary method to confirm the presence of a [[mass]] in the [[eyeball]].<ref>{{cite book | last = Dutta | first = L. C. | title = Modern ophthalmology | publisher = Jaypee Bros | location = New Delhi, India | year = 2005 | isbn = 978-8180614705 }}</ref>
*This [[Imaging studies|imaging method]] is useful in:
**Measuring the [[Dimension|dimensions]] of [[mass]]
**Detecting associated [[vitreous]] seeds or [[retinal detachment]]
**Excluding [[optic nerve]] invasion
*On [[ultrasound imaging]], [[retinoblastoma]] appears as:
**A dome-shaped solid [[mass]] with variable [[internal]] reflectivity.
**Intralesional [[calcification]] may or may not be seen.
*The [[accuracy]] of this [[Imaging studies|imaging study]] in [[Diagnosis|diagnosing]] [[retinoblastoma]] has been observed to be between 87.5% to 100%.<ref name="pmid8586499">{{cite journal |vauthors=Zilelioğlu G, Gündüz K |title=Ultrasonic findings in intraocular retinoblastoma and correlation with histopathologic diagnosis |journal=Int Ophthalmol |volume=19 |issue=2 |pages=71–5 |date=1995 |pmid=8586499 |doi= |url=}}</ref><ref name="Nagaraju2015">{{cite journal|last1=Nagaraju|first1=Rashmi M|title=Efficacy of High Frequency Ultrasound in Localization and Characterization of Orbital Lesions|journal=JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH|year=2015|issn=2249782X|doi=10.7860/JCDR/2015/13021.6428}}</ref>
==References==
==References==
<references/>
{{reflist|2}}


==See also==
[[Category:Medicine]]
*[[Eye cancer]]
*[[Eye examination]]
 
 
{{Nervous tissue tumors}}
 
[[Category:Ophthalmology]]
[[Category:Types of cancer]]
[[Category:hereditary cancers]]
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Oncology stub]]
[[Category:Up-To-Date]]
 
[[Category:Surgery]]
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Latest revision as of 23:59, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2] Simrat Sarai, M.D. [3]

Overview

On ultrasound imaging, retinoblastoma is characterized by echogenic soft-tissue masses with variable shadowing due to calcification and heterogeneity due to necrosis and/or hemorrhage.

Ultrasound

References

  1. Dutta, L. C. (2005). Modern ophthalmology. New Delhi, India: Jaypee Bros. ISBN 978-8180614705.
  2. Zilelioğlu G, Gündüz K (1995). "Ultrasonic findings in intraocular retinoblastoma and correlation with histopathologic diagnosis". Int Ophthalmol. 19 (2): 71–5. PMID 8586499.
  3. Nagaraju, Rashmi M (2015). "Efficacy of High Frequency Ultrasound in Localization and Characterization of Orbital Lesions". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. doi:10.7860/JCDR/2015/13021.6428. ISSN 2249-782X.