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{{Primary central nervous system lymphoma}}
{{Primary central nervous system lymphoma}}
{{CMG}}
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==Overview==
==Overview==
'''Primary CNS lymphoma''' is a [[brain tumor|primary intracranial tumor]] usually present in those with severe immunosuppression --- commonly in those with [[AIDS]] --- and represents around 20% of all cases of lymphomas in HIV infection (other types being [[Burkitt's lymphoma]] and immunoblastic lymphoma).
Symptoms of primary central nervous system lymphoma are identical to the other types of brain tumors and depend on the area of the brain that is affected.Primary central nervous system lymphoma is multifocal.  Symptoms of primary nervous system lymphoma include [[headache]], [[nausea]], [[vomiting]], [[Dysphagia|difficulty swallowing]], [[vision loss|monocular vision loss]], [[Muscle weakness|Muscle weakness or paralysis]], [[memory loss]], [[hypoesthesia|facial hypoesthesia]], [[seizures]], [[fever]], [[night sweats]], and [[weight loss]].
 
==History==


==Symptoms==
==Symptoms==
*Symptoms of primary central nervous system lymphoma are identical to the other types of brain tumors and depend on the area of the brain that is affected.<ref name=signsandsymptomsofprimarycnslymphoma1>Signs and symptoms of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016</ref>
*Symptoms of primary central nervous system lymphoma are identical to the other types of brain tumors and depend on the area of the brain that is affected.<ref name="signsandsymptomsofprimarycnslymphoma1">Signs and symptoms of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016</ref>
*Primary central nervous system lymphoma is '''multifocal''' (tumors in different parts of the brain)
*Primary central nervous system lymphoma is multifocal (tumors in different parts of the [[brain]]).
*Symptoms of primary nervous system lymphoma include:<ref name=signsandsymptomsofprimarycnslymphoma1>Signs and symptoms of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016</ref><ref name=signsandsymptomsprimarycnslymphomawiki1>Signs and symptoms of primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016</ref>
*[[Symptom|Symptoms]] of primary nervous system lymphoma include:<ref name="signsandsymptomsofprimarycnslymphoma1">Signs and symptoms of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016</ref><ref name="signsandsymptomsprimarycnslymphomawiki1">Signs and symptoms of primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016</ref><ref name="Ferreri2011">{{cite journal|last1=Ferreri|first1=A. J. M.|title=How I treat primary CNS lymphoma|journal=Blood|volume=118|issue=3|year=2011|pages=510–522|issn=0006-4971|doi=10.1182/blood-2011-03-321349}}</ref>
:*[[Headache]]
:*[[Headache]]
:*[[Nausea]]
:*[[Nausea]]
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:*[[vision loss|Monocular vision loss]]
:*[[vision loss|Monocular vision loss]]
:*[[Vertigo]]
:*[[Vertigo]]
:*[[Muscle weakness or paralysis]]
:*[[Muscle weakness|Muscle weakness or paralysis]]
:*[[aphasia|Trouble speaking]]
:*[[aphasia|Trouble speaking]]
:*[[Memory loss]]
:*[[Memory loss]]
:*[[Confusion]]
:*[[Confusion]]
:*[[Lethargy]]
:*[[dementia|Progressive dementia]] or [[stupor]] in patients with a nonfocal neurologic exam and minimal abnormalities on MRI (more common in [[AIDS]] patients)
:*[[dementia|Progressive dementia]] or [[stupor]] in patients with a nonfocal neurologic exam and minimal abnormalities on MRI (more common in [[AIDS]] patients)
:*[[hypoesthesia|Facial hypoesthesia]]
:*[[hypoesthesia|Facial hypoesthesia]]
:*[[Seizures]] (uncommon)
:*[[Seizures]] (uncommon)
 
:*[[Fever]]
 
:*[[Night sweats]]
 
:*[[Weight loss]]
Primary CNS lymphoma usually presents with [[seizures]], [[headache]], cranial nerve findings, altered mental status, or other focal neurological deficits typical of a mass effect<ref>Herrlinger U, Schabet M, Bitzer M, Petersen D, Krauseneck P. Primary central nervous system lymphoma: from clinical presentation to diagnosis. ''J Neurosurg'' 2000; 92:261-266</ref> <ref> Herrlinger U, Schabet M, Bitzer M, Petersen D, Krauseneck P. Primary central nervous system lymphoma: from clinical presentation to diagnosis.''J.Neurooncol.'' 1999;43:219-226. (PMID: 10563426).</ref>.  Systemic symptoms may include [[fever]], [[night sweats]], or [[weight loss]].


==References==
==References==
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Latest revision as of 17:10, 20 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Symptoms of primary central nervous system lymphoma are identical to the other types of brain tumors and depend on the area of the brain that is affected.Primary central nervous system lymphoma is multifocal. Symptoms of primary nervous system lymphoma include headache, nausea, vomiting, difficulty swallowing, monocular vision loss, Muscle weakness or paralysis, memory loss, facial hypoesthesia, seizures, fever, night sweats, and weight loss.

Symptoms

  • Symptoms of primary central nervous system lymphoma are identical to the other types of brain tumors and depend on the area of the brain that is affected.[1]
  • Primary central nervous system lymphoma is multifocal (tumors in different parts of the brain).
  • Symptoms of primary nervous system lymphoma include:[1][2][3]

References

  1. 1.0 1.1 Signs and symptoms of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016
  2. Signs and symptoms of primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016
  3. Ferreri, A. J. M. (2011). "How I treat primary CNS lymphoma". Blood. 118 (3): 510–522. doi:10.1182/blood-2011-03-321349. ISSN 0006-4971.

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