Pancreatic cancer natural history, complications and prognosis: Difference between revisions

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The percentage of people who live for a minimum of five years after diagnosis is called the 5- year survival rate.
=== Five year survival rate ===
Survival rates for exocrine pancreatic cancer
* The percentage of people who live for a minimum of five years after diagnosis is called the 5- year survival rate.
Lifespan is found to be longer in patients treated with surgery, as opposed to other patients.
* Survival rates for exocrine pancreatic cancer:
The 5-year survival rate for people at various stages of pancreatic cancer are as follows:
** Lifespan is found to be longer in patients treated with surgery, as opposed to other patients.
stage IA: 14%  
** The 5-year survival rate for people at various stages of pancreatic cancer are as follows based on the most recent statistics of the American Cancer Society are as follows:
stage IB cancer 12%  
*** Stage IA: 14%  
stage IIA 7%
*** Stage IB: 12%  
stage IIB 5%
*** Stage IIA 7%
stage III 3%
*** Stage IIB 5%
Stage IV 1%
*** Stage III 3%
•Survival rates for neuroendocrine pancreatic tumors (treated with surgery)
*** Stage IV 1%
•stage I pancreatic NETs 61%.
** Survival rates for neuroendocrine pancreatic tumors (treated with surgery) are as follows:
•stage II pancreatic NETs 52%.
*** Stage I pancreatic NETs 61%  
•stage III pancreatic NETs 41%.
*** Stage II pancreatic NETs 52%
•Stage IV pancreatic NETs 16%. Still,
*** Stage III pancreatic NETs 41%
•tumors not removed by surgery was 16%
*** Stage IV pancreatic NETs 16%.  
** Five year survival rate of tumors not removed by surgery is 16%


==References==
==References==

Revision as of 15:39, 15 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2] Sudarshana Datta, MD [3]

Overview

The symptoms of pancreatic cancer usually develop in the sixth decade of life, and start with symptoms such as jaundice, light-colored stools, dark urine, pain in the upper or middle abdomen and back, unexplained weight loss, anorexia and fatigue.Symptoms typically develop about 20-30 years after exposure to risk factors such as smoking and alcohol. Genetic factors such as alterations in tumor suppressor genes, oncogenes and different signaling pathways are responsible. If left untreated, patients with pancreatic cancer may progress to develop exocrine pancreatic insufficiency arising from pancreatic duct obstruction leading to malabsorption, malnutrition and cachexia. Dudodenal obstruction and biliary obstruction may cause symptoms of bowel obstruction and jaundice. Common complications of pancreatic cancer may arise as a result of the disease or therapy (surgical or medical). Depending on the extent of the tumor at the time of diagnosis, the prognosis is generally regarded as poor, with complete remission extremely rare.

Natural History, Complications and Prognosis

Natural History

Complications

Malabsorption:

Pain

Jaundice

Duodenal obstruction

Prognosis

  • The primary factors that influence prognosis are:
  • Whether the tumor is localized and can be completely resected
  • Whether the tumor has spread to lymph nodes or elsewhere


  • Staging and TNM (tumour, lymph node, metastasis) classification related to incidence, treatment, and prognosis: [1]
Staging and TNM Classification related to Incidence, Treatment, and Prognosis
Stage TNM Classification Clinical Classification Incidence at diagnosis (%) 5-year survival rate (%)
0 Tis, N0, M0 Resectable 7.5 15.2
IA T1, N0, M0
IB T2, N0, M0
IIA T3, N0, M0
IIB T1-3, N1, M0 Locally advanced 29.3 6.3
III T4, any N, M0
IV Any T, any N, M1 Metastatic 47.2 1.6

Five year survival rate

  • The percentage of people who live for a minimum of five years after diagnosis is called the 5- year survival rate.
  • Survival rates for exocrine pancreatic cancer:
    • Lifespan is found to be longer in patients treated with surgery, as opposed to other patients.
    • The 5-year survival rate for people at various stages of pancreatic cancer are as follows based on the most recent statistics of the American Cancer Society are as follows:
      • Stage IA: 14%
      • Stage IB: 12%
      • Stage IIA 7%
      • Stage IIB 5%
      • Stage III 3%
      • Stage IV 1%
    • Survival rates for neuroendocrine pancreatic tumors (treated with surgery) are as follows:
      • Stage I pancreatic NETs 61%
      • Stage II pancreatic NETs 52%
      • Stage III pancreatic NETs 41%
      • Stage IV pancreatic NETs 16%.
    • Five year survival rate of tumors not removed by surgery is 16%

References

  1. Bond-Smith G, Banga N, Hammond TM, Imber CJ (2012). "Pancreatic adenocarcinoma". BMJ. 344: e2476. doi:10.1136/bmj.e2476. PMID 22592847.



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