Paget's disease of the breast history and symptoms: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(25 intermediate revisions by 3 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Paget's disease of the breast}}
{{Paget's disease of the breast}}
{{CMG}}
{{CMG}};{{AE}} {{PSK}}
==Overview==
==Overview==
Symptoms of Paget's disease of the breast include [[itching]], redness, thickened skin, and ulceration that begins at the [[nipple]] and spreads to the [[areola]] but can spread to surrounding [[skin]]. [[Lesion]] is sharply demarcated from the adjacent normal [[skin]]. Advanced [[lesions]] present as a round, ovoid or polycylic [[eczema]]-like plaque with a pink or red discoloration.
==History and symptoms==
==History and symptoms==
The symptoms of Paget's disease of the breast are often mistaken for those of some benign skin conditions, such as dermatitis or eczema. These symptoms may include the following:
*Itching, tingling, or redness in the nipple and/or areola
*Flaking, crusty, or thickened skin on or around the nipple
*A flattened nipple
*Discharge from the nipple that may be yellowish or bloody


Because the early symptoms of Paget disease of the breast may suggest a benign skin condition, and because the disease is rare, it may be misdiagnosed at first. People with Paget disease of the breast have often had symptoms for several months before being correctly diagnosed.
=== History ===
A detailed history documenting the length of time the lesion along with any associated symptoms should be taken.By clinical history, the cancer risk can be evaluated:<ref name="pmid25114845">{{cite journal| author=Shah R, Rosso K, Nathanson SD| title=Pathogenesis, prevention, diagnosis and treatment of breast cancer. | journal=World J Clin Oncol | year= 2014 | volume= 5 | issue= 3 | pages= 283-98 | pmid=25114845 | doi=10.5306/wjco.v5.i3.283 | pmc=4127601 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25114845  }} </ref>
* Age at [[menarche]]
 
* [[Menopausal|Menopausa]]<nowiki/>l status
* Number of<nowiki/> [[pregnancies]]
* Previous history of [[radiation]]
* History of [[Oral contraceptive|oral contraceptives]] or [[hormone replacement therapy]]
* Past history of [[breast cancer]] and age at time of diagnosis
* Familial history of [[breast cancer]] or [[ovarian cancer]] in first-degree relatives
* Other associated [[breast]] disease or possible biopsies
 
===Symptoms===
 
Symptoms of Paget's disease of the breast usually occur in one breast but can present bilaterally. Some patients have two or more or a combination of the below symptoms at presentation. They can also be asymptomatic. Symptoms of Paget's disease of the breast include: <ref name="pmid16933329">{{cite journal |vauthors=Chen CY, Sun LM, Anderson BO |title=Paget disease of the breast: changing patterns of incidence, clinical presentation, and treatment in the U.S |journal=Cancer |volume=107 |issue=7 |pages=1448–58 |date=October 2006 |pmid=16933329 |doi=10.1002/cncr.22137 |url=}}</ref><ref name="pmid17447970">{{cite journal |vauthors=Kanitakis J |title=Mammary and extramammary Paget's disease |journal=J Eur Acad Dermatol Venereol |volume=21 |issue=5 |pages=581–90 |date=May 2007 |pmid=17447970 |doi=10.1111/j.1468-3083.2007.02154.x |url=}}</ref><ref name="pmid4318756">{{cite journal |vauthors=Ashikari R, Park K, Huvos AG, Urban JA |title=Paget's disease of the breast |journal=Cancer |volume=26 |issue=3 |pages=680–5 |date=September 1970 |pmid=4318756 |doi= |url=}}</ref><ref name="pmid27178684">{{cite journal |vauthors=Tan AR |title=Cutaneous manifestations of breast cancer |journal=Semin. Oncol. |volume=43 |issue=3 |pages=331–4 |date=June 2016 |pmid=27178684 |doi=10.1053/j.seminoncol.2016.02.030 |url=}}</ref><ref name="pmid16174159">{{cite journal |vauthors=Franceschini G, Masetti R, D'Ugo D, Palumbo F, D'Alba P, Mulè A, Costantini M, Belli P, Picciocchi A |title=Synchronous bilateral Paget's disease of the nipple associated with bilateral breast carcinoma |journal=Breast J |volume=11 |issue=5 |pages=355–6 |date=2005 |pmid=16174159 |doi=10.1111/j.1075-122X.2005.21722.x |url=}}</ref><ref>{{cite book | last = Rosen | first = Paul | title = Rosen's breast pathology | publisher = Wolters Kluwer Health/Lippincott Williams & Wilkins | location = Philadelphia | year = 2014 | isbn = 9781451176537 }}</ref>
 
*[[Pruritis]] or [[erythema]] of the [[nipple]] and/or [[areola]].
*Flaking, crusting, or thickening of the [[skin]] that begins at the [[nipple]] and spreads to the [[areola]] with irregular borders but can spread to surrounding [[skin]].
*Erosion or [[ulceration]] of the [[nipple]].
*A flattened, inverted or [[retracted nipple]].
*Bloody or serosanguinous [[Nipple Discharge|discharge from the nipple]].
*A palpable [[Breast lump|breast mass]] is present in 50% of patients.
*Advanced [[lesions]] present as a round, ovoid or polycylic [[eczema]]-like plaque with a pink or red discoloration.
*[[Lesion]] is sharply demarcated from the adjacent normal [[skin]].


==References==
==References==
Line 25: Line 45:
[[Category:Breast]]
[[Category:Breast]]
[[Category:Mature chapter]]
[[Category:Mature chapter]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Gynecology]]
[[Category:Surgery]]

Latest revision as of 17:39, 14 March 2019

Paget's disease of the breast Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Paget's disease of the breast from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Biopsy

Ultrasonography

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Paget's disease of the breast history and symptoms On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Paget's disease of the breast history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Paget's disease of the breast history and symptoms

CDC on Paget's disease of the breast history and symptoms

Paget's disease of the breast history and symptoms in the news

Blogs on Paget's disease of the breast history and symptoms

Directions to Hospitals Treating Paget's disease of the breast

Risk calculators and risk factors for Paget's disease of the breast history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Symptoms of Paget's disease of the breast include itching, redness, thickened skin, and ulceration that begins at the nipple and spreads to the areola but can spread to surrounding skin. Lesion is sharply demarcated from the adjacent normal skin. Advanced lesions present as a round, ovoid or polycylic eczema-like plaque with a pink or red discoloration.

History and symptoms

History

A detailed history documenting the length of time the lesion along with any associated symptoms should be taken.By clinical history, the cancer risk can be evaluated:[1]

Symptoms

Symptoms of Paget's disease of the breast usually occur in one breast but can present bilaterally. Some patients have two or more or a combination of the below symptoms at presentation. They can also be asymptomatic. Symptoms of Paget's disease of the breast include: [2][3][4][5][6][7]

References

  1. Shah R, Rosso K, Nathanson SD (2014). "Pathogenesis, prevention, diagnosis and treatment of breast cancer". World J Clin Oncol. 5 (3): 283–98. doi:10.5306/wjco.v5.i3.283. PMC 4127601. PMID 25114845.
  2. Chen CY, Sun LM, Anderson BO (October 2006). "Paget disease of the breast: changing patterns of incidence, clinical presentation, and treatment in the U.S". Cancer. 107 (7): 1448–58. doi:10.1002/cncr.22137. PMID 16933329.
  3. Kanitakis J (May 2007). "Mammary and extramammary Paget's disease". J Eur Acad Dermatol Venereol. 21 (5): 581–90. doi:10.1111/j.1468-3083.2007.02154.x. PMID 17447970.
  4. Ashikari R, Park K, Huvos AG, Urban JA (September 1970). "Paget's disease of the breast". Cancer. 26 (3): 680–5. PMID 4318756.
  5. Tan AR (June 2016). "Cutaneous manifestations of breast cancer". Semin. Oncol. 43 (3): 331–4. doi:10.1053/j.seminoncol.2016.02.030. PMID 27178684.
  6. Franceschini G, Masetti R, D'Ugo D, Palumbo F, D'Alba P, Mulè A, Costantini M, Belli P, Picciocchi A (2005). "Synchronous bilateral Paget's disease of the nipple associated with bilateral breast carcinoma". Breast J. 11 (5): 355–6. doi:10.1111/j.1075-122X.2005.21722.x. PMID 16174159.
  7. Rosen, Paul (2014). Rosen's breast pathology. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. ISBN 9781451176537.


Template:WikiDoc Sources