PPARGC1B: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Peroxisome proliferator-activated receptor gamma coactivator 1-beta''' is a [[protein]] that in humans is encoded by the ''PPARGC1B'' [[gene]].<ref name="pmid11793024">{{cite journal | vauthors = Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O | title = Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus | journal = Diabetologia | volume = 44 | issue = 12 | pages = 2220–6 |date=Jan 2002 | pmid = 11793024 | pmc = | doi = 10.1007/s001250100032 }}</ref><ref name="pmid11854298">{{cite journal | vauthors = Kressler D, Schreiber SN, Knutti D, Kralli A | title = The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha | journal = J Biol Chem | volume = 277 | issue = 16 | pages = 13918–25 |date=Apr 2002 | pmid = 11854298 | pmc =  | doi = 10.1074/jbc.M201134200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=133522| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Peroxisome proliferator-activated receptor gamma, coactivator 1 beta
| HGNCid = 30022
| Symbol = PPARGC1B
| AltSymbols =; PERC; PGC-1(beta); PGC1B
| OMIM = 608886
| ECnumber =
| Homologene = 15776
| MGIid = 2444934
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0016455 |text = RNA polymerase II transcription mediator activity}} {{GNF_GO|id=GO:0030331 |text = estrogen receptor binding}} {{GNF_GO|id=GO:0030374 |text = ligand-dependent nuclear receptor transcription coactivator activity}} {{GNF_GO|id=GO:0030546 |text = receptor activator activity}} {{GNF_GO|id=GO:0050682 |text = AF-2 domain binding}}
| Component = {{GNF_GO|id=GO:0000119 |text = mediator complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0030520 |text = estrogen receptor signaling pathway}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 133522
    | Hs_Ensembl = ENSG00000155846
    | Hs_RefseqProtein = NP_573570
    | Hs_RefseqmRNA = NM_133263
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 149090057
    | Hs_GenLoc_end = 149207460
    | Hs_Uniprot = Q86YN6
    | Mm_EntrezGene = 170826
    | Mm_Ensembl = ENSMUSG00000033871
    | Mm_RefseqmRNA = NM_133249
    | Mm_RefseqProtein = NP_573512
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 61423505
    | Mm_GenLoc_end = 61525800
    | Mm_Uniprot = Q8VHJ7
  }}
}}
'''Peroxisome proliferator-activated receptor gamma, coactivator 1 beta''', also known as '''PPARGC1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=133522| accessdate = }}</ref>


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==See also==
==See also==
* [[PPARGC1A]]
* [[Peroxisome proliferator-activated receptor]]
* [[Peroxisome proliferator-activated receptor alpha]]
* [[Peroxisome proliferator-activated receptor delta]]
* [[Peroxisome proliferator-activated receptor gamma]]
* [[Transcription coregulator]]
* [[Transcription coregulator]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{MeshName|PPARGC1B+protein,+human|3=PPARGC1B protein, human}}
* {{NURSA|C21}}


==Further reading==
==Further reading==
Line 63: Line 27:
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Handschin C, Spiegelman BM |title=Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. |journal=Endocr. Rev. |volume=27 |issue= 7 |pages= 728-35 |year= 2007 |pmid= 17018837 |doi= 10.1210/er.2006-0037 }}
*{{cite journal  | vauthors=Handschin C, Spiegelman BM |title=Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. |journal=Endocr. Rev. |volume=27 |issue= 7 |pages= 728–35 |year= 2007 |pmid= 17018837 |doi= 10.1210/er.2006-0037 }}
*{{cite journal  | author=Esterbauer H, Oberkofler H, Krempler F, Patsch W |title=Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. |journal=Genomics |volume=62 |issue= 1 |pages= 98-102 |year= 2000 |pmid= 10585775 |doi= 10.1006/geno.1999.5977 }}
*{{cite journal  | vauthors=Esterbauer H, Oberkofler H, Krempler F, Patsch W |title=Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. |journal=Genomics |volume=62 |issue= 1 |pages= 98–102 |year= 2000 |pmid= 10585775 |doi= 10.1006/geno.1999.5977 }}
*{{cite journal  | author=Knutti D, Kaul A, Kralli A |title=A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2411-22 |year= 2000 |pmid= 10713165 |doi=  }}
*{{cite journal  | vauthors=Knutti D, Kaul A, Kralli A |title=A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2411–22 |year= 2000 |pmid= 10713165 |doi=10.1128/MCB.20.7.2411-2422.2000  | pmc=85422 }}
*{{cite journal | author=Lin J, Puigserver P, Donovan J, ''et al.'' |title=Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. |journal=J. Biol. Chem. |volume=277 |issue= 3 |pages= 1645-8 |year= 2002 |pmid= 11733490 |doi= 10.1074/jbc.C100631200 }}
*{{cite journal   |vauthors=Lin J, Puigserver P, Donovan J, etal |title=Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. |journal=J. Biol. Chem. |volume=277 |issue= 3 |pages= 1645–8 |year= 2002 |pmid= 11733490 |doi= 10.1074/jbc.C100631200 }}
*{{cite journal | author=Ek J, Andersen G, Urhammer SA, ''et al.'' |title=Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. |journal=Diabetologia |volume=44 |issue= 12 |pages= 2220-6 |year= 2002 |pmid= 11793024 |doi= 10.1007/s001250100032 }}
*{{cite journal   |vauthors=Lacquemant C, Chikri M, Boutin P, etal |title=No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians. |journal=Diabetologia |volume=45 |issue= 4 |pages= 602–3; author reply 604 |year= 2002 |pmid= 12032643 |doi= 10.1007/s00125-002-0783-z }}
*{{cite journal | author=Kressler D, Schreiber SN, Knutti D, Kralli A |title=The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13918-25 |year= 2002 |pmid= 11854298 |doi= 10.1074/jbc.M201134200 }}
*{{cite journal   |vauthors=Hara K, Tobe K, Okada T, etal |title=A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. |journal=Diabetologia |volume=45 |issue= 5 |pages= 740–3 |year= 2003 |pmid= 12107756 |doi= 10.1007/s00125-002-0803-z }}
*{{cite journal  | author=Lacquemant C, Chikri M, Boutin P, ''et al.'' |title=No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians. |journal=Diabetologia |volume=45 |issue= 4 |pages= 602-3; author reply 604 |year= 2002 |pmid= 12032643 |doi= 10.1007/s00125-002-0783-z }}
*{{cite journal  | vauthors=Huss JM, Kopp RP, Kelly DP |title=Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40265–74 |year= 2002 |pmid= 12181319 |doi= 10.1074/jbc.M206324200 }}
*{{cite journal  | author=Hara K, Tobe K, Okada T, ''et al.'' |title=A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. |journal=Diabetologia |volume=45 |issue= 5 |pages= 740-3 |year= 2003 |pmid= 12107756 |doi= 10.1007/s00125-002-0803-z }}
*{{cite journal  | vauthors=Hentschke M, Süsens U, Borgmeyer U |title=PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 5 |pages= 872–9 |year= 2003 |pmid= 12470660 |doi=10.1016/S0006-291X(02)02753-5  }}
*{{cite journal | author=Huss JM, Kopp RP, Kelly DP |title=Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40265-74 |year= 2002 |pmid= 12181319 |doi= 10.1074/jbc.M206324200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Hentschke M, Süsens U, Borgmeyer U |title=PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 5 |pages= 872-9 |year= 2003 |pmid= 12470660 |doi= }}
*{{cite journal  | vauthors=Shiraki T, Sakai N, Kanaya E, Jingami H |title=Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11344–50 |year= 2003 |pmid= 12551939 |doi= 10.1074/jbc.M212859200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hammarstedt A, Jansson PA, Wesslau C, etal |title=Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 578–82 |year= 2003 |pmid= 12565902 |doi=10.1016/S0006-291X(03)00014-7  }}
*{{cite journal | author=Shiraki T, Sakai N, Kanaya E, Jingami H |title=Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11344-50 |year= 2003 |pmid= 12551939 |doi= 10.1074/jbc.M212859200 }}
*{{cite journal   |vauthors=Meirhaeghe A, Crowley V, Lenaghan C, etal |title=Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 155–65 |year= 2003 |pmid= 12678921 |doi= 10.1042/BJ20030200  | pmc=1223480 }}
*{{cite journal | author=Hammarstedt A, Jansson PA, Wesslau C, ''et al.'' |title=Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 578-82 |year= 2003 |pmid= 12565902 |doi=  }}
*{{cite journal   |vauthors=Patti ME, Butte AJ, Crunkhorn S, etal |title=Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8466–71 |year= 2003 |pmid= 12832613 |doi= 10.1073/pnas.1032913100 | pmc=166252 }}
*{{cite journal | author=Meirhaeghe A, Crowley V, Lenaghan C, ''et al.'' |title=Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 155-65 |year= 2003 |pmid= 12678921 |doi= 10.1042/BJ20030200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Patti ME, Butte AJ, Crunkhorn S, ''et al.'' |title=Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8466-71 |year= 2003 |pmid= 12832613 |doi= 10.1073/pnas.1032913100 }}
*{{cite journal   |vauthors=Ling C, Poulsen P, Carlsson E, etal |title=Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins. |journal=J. Clin. Invest. |volume=114 |issue= 10 |pages= 1518–26 |year= 2004 |pmid= 15546003 |doi= 10.1172/JCI21889  | pmc=525741 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Andersen G, Wegner L, Yanagisawa K, etal |title=Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. |journal=J. Med. Genet. |volume=42 |issue= 5 |pages= 402–7 |year= 2006 |pmid= 15863669 |doi= 10.1136/jmg.2004.026278 | pmc=1736055 }}
*{{cite journal | author=Ling C, Poulsen P, Carlsson E, ''et al.'' |title=Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins. |journal=J. Clin. Invest. |volume=114 |issue= 10 |pages= 1518-26 |year= 2004 |pmid= 15546003 |doi= 10.1172/JCI200421889 }}
*{{cite journal   |vauthors=Staiger H, Staiger K, Haas C, etal |title=Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro. |journal=Diabetologia |volume=48 |issue= 10 |pages= 2115–8 |year= 2005 |pmid= 16132959 |doi= 10.1007/s00125-005-1895-z }}
*{{cite journal  | author=Andersen G, Wegner L, Yanagisawa K, ''et al.'' |title=Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. |journal=J. Med. Genet. |volume=42 |issue= 5 |pages= 402-7 |year= 2006 |pmid= 15863669 |doi= 10.1136/jmg.2004.026278 }}
*{{cite journal   |vauthors=Wirtenberger M, Tchatchou S, Hemminki K, etal |title=Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer. |journal=Carcinogenesis |volume=27 |issue= 11 |pages= 2201–8 |year= 2006 |pmid= 16704985 |doi= 10.1093/carcin/bgl067 }}
*{{cite journal | author=Staiger H, Staiger K, Haas C, ''et al.'' |title=Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro. |journal=Diabetologia |volume=48 |issue= 10 |pages= 2115-8 |year= 2005 |pmid= 16132959 |doi= 10.1007/s00125-005-1895-z }}
*{{cite journal | author=Wirtenberger M, Tchatchou S, Hemminki K, ''et al.'' |title=Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer. |journal=Carcinogenesis |volume=27 |issue= 11 |pages= 2201-8 |year= 2006 |pmid= 16704985 |doi= 10.1093/carcin/bgl067 }}
}}
}}
{{refend}}
{{refend}}


==External links==
* {{MeshName|PPARGC1B+protein,+human}}
{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription coregulators}}
{{Transcription coregulators}}
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[[Category:Gene expression]]
[[Category:Gene expression]]
[[Category:Transcription coregulators]]
[[Category:Transcription coregulators]]
{{WikiDoc Sources}}
 
 
{{gene-5-stub}}

Latest revision as of 18:30, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.[1][2][3]


See also

References

  1. ↑ Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O (Jan 2002). "Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus". Diabetologia. 44 (12): 2220–6. doi:10.1007/s001250100032. PMID 11793024.
  2. ↑ Kressler D, Schreiber SN, Knutti D, Kralli A (Apr 2002). "The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha". J Biol Chem. 277 (16): 13918–25. doi:10.1074/jbc.M201134200. PMID 11854298.
  3. ↑ "Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta".

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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