PDGFD: Difference between revisions

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{{Infobox_gene}}
{{GNF_Protein_box
'''Platelet-derived growth factor D''' is a [[protein]] that in humans is encoded by the ''PDGFD'' [[gene]].<ref name="pmid11162582">{{cite journal | vauthors = Hamada T, Ui-Tei K, Imaki J, Miyata Y | title = Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein | journal = Biochem Biophys Res Commun | volume = 280 | issue = 3 | pages = 733–7 |date=Feb 2001 | pmid = 11162582 | pmc =  | doi = 10.1006/bbrc.2000.4187 }}</ref><ref name="pmid11980634">{{cite journal | vauthors = LaRochelle WJ, Jeffers M, Corvalan JR, Jia XC, Feng X, Vanegas S, Vickroy JD, Yang XD, Chen F, Gazit G, Mayotte J, Macaluso J, Rittman B, Wu F, Dhanabal M, Herrmann J, Lichenstein HS | title = Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer | journal = Cancer Res | volume = 62 | issue = 9 | pages = 2468–73 |date=Apr 2002 | pmid = 11980634 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDGFD platelet derived growth factor D| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80310| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Platelet derived growth factor D
| HGNCid = 30620
| Symbol = PDGFD
| AltSymbols =; IEGF; MGC26867; MSTP036; SCDGF-B
| OMIM = 609673
| ECnumber = 
| Homologene = 11875
| MGIid = 1919035
| GeneAtlas_image1 = PBB_GE_PDGFD_219304_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PDGFD_gnf1h09263_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
  | Component = {{GNF_GO|id=GO:0016020 |text = membrane}}  
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0050730 |text = regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 80310
    | Hs_Ensembl = ENSG00000170962
    | Hs_RefseqProtein = NP_079484
    | Hs_RefseqmRNA = NM_025208
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 103283131
    | Hs_GenLoc_end = 103540317
    | Hs_Uniprot = Q9GZP0
    | Mm_EntrezGene = 71785
    | Mm_Ensembl = ENSMUSG00000032006
    | Mm_RefseqmRNA = NM_027924
    | Mm_RefseqProtein = NP_082200
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 6168612
    | Mm_GenLoc_end = 6377519
    | Mm_Uniprot = Q925I7
  }}
}}
'''Platelet derived growth factor D''', also known as '''PDGFD''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDGFD platelet derived growth factor D| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80310| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PDGFD platelet derived growth factor D| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80310| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the [[platelet-derived growth factor]] family. The four members of this family are [[mitogenic]] factors for cells of [[mesenchymal]] origin and are characterized by a core [[Structural motif|motif]] of eight cysteines, seven of which are found in this factor. This gene product only forms [[homodimers]] and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual [[N-terminal]] domain, the [[CUB domain]]. Two splice variants have been identified for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Hamada T, Ui-Tei K, Imaki J, Miyata Y |title=Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 3 |pages= 733-7 |year= 2001 |pmid= 11162582 |doi= 10.1006/bbrc.2000.4187 }}
*{{cite journal   |vauthors=Bergsten E, Uutela M, Li X, etal |title=PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor |journal=Nat. Cell Biol. |volume=3 |issue= 5 |pages= 512–6 |year= 2001 |pmid= 11331881 |doi= 10.1038/35074588 }}
*{{cite journal  | author=Bergsten E, Uutela M, Li X, ''et al.'' |title=PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. |journal=Nat. Cell Biol. |volume=3 |issue= 5 |pages= 512-6 |year= 2001 |pmid= 11331881 |doi= 10.1038/35074588 }}
*{{cite journal   |vauthors=LaRochelle WJ, Jeffers M, McDonald WF, etal |title=PDGF-D, a new protease-activated growth factor |journal=Nat. Cell Biol. |volume=3 |issue= 5 |pages= 517–21 |year= 2001 |pmid= 11331882 |doi= 10.1038/35074593 }}
*{{cite journal | author=LaRochelle WJ, Jeffers M, McDonald WF, ''et al.'' |title=PDGF-D, a new protease-activated growth factor. |journal=Nat. Cell Biol. |volume=3 |issue= 5 |pages= 517-21 |year= 2001 |pmid= 11331882 |doi= 10.1038/35074593 }}
*{{cite journal   |vauthors=Uutela M, Laurén J, Bergsten E, etal |title=Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes |journal=Circulation |volume=103 |issue= 18 |pages= 2242–7 |year= 2001 |pmid= 11342471 |doi=  10.1161/01.cir.103.18.2242}}
*{{cite journal | author=Uutela M, Laurén J, Bergsten E, ''et al.'' |title=Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes. |journal=Circulation |volume=103 |issue= 18 |pages= 2242-7 |year= 2001 |pmid= 11342471 |doi=  }}
*{{cite journal   |vauthors=Wistow G, Bernstein SL, Ray S, etal |title=Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium |journal=Mol. Vis. |volume=8 |issue=  |pages= 185–95 |year= 2002 |pmid= 12107412 |doi=  }}
*{{cite journal  | author=LaRochelle WJ, Jeffers M, Corvalan JR, ''et al.'' |title=Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer. |journal=Cancer Res. |volume=62 |issue= 9 |pages= 2468-73 |year= 2002 |pmid= 11980634 |doi=  }}
*{{cite journal   |vauthors=Changsirikulchai S, Hudkins KL, Goodpaster TA, etal |title=Platelet-derived growth factor-D expression in developing and mature human kidneys |journal=Kidney Int. |volume=62 |issue= 6 |pages= 2043–54 |year= 2003 |pmid= 12427128 |doi= 10.1046/j.1523-1755.2002.00662.x }}
*{{cite journal | author=Wistow G, Bernstein SL, Ray S, ''et al.'' |title=Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium. |journal=Mol. Vis. |volume=8 |issue=  |pages= 185-95 |year= 2002 |pmid= 12107412 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Changsirikulchai S, Hudkins KL, Goodpaster TA, ''et al.'' |title=Platelet-derived growth factor-D expression in developing and mature human kidneys. |journal=Kidney Int. |volume=62 |issue= 6 |pages= 2043-54 |year= 2003 |pmid= 12427128 |doi= 10.1046/j.1523-1755.2002.00662.x }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Taneda S, Hudkins KL, Topouzis S, etal |title=Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury |journal=J. Am. Soc. Nephrol. |volume=14 |issue= 10 |pages= 2544–55 |year= 2004 |pmid= 14514732 |doi=10.1097/01.ASN.0000089828.73014.C8 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Uutela M, Wirzenius M, Paavonen K, etal |title=PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis |journal=Blood |volume=104 |issue= 10 |pages= 3198–204 |year= 2004 |pmid= 15271796 |doi= 10.1182/blood-2004-04-1485 }}
*{{cite journal | author=Taneda S, Hudkins KL, Topouzis S, ''et al.'' |title=Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury. |journal=J. Am. Soc. Nephrol. |volume=14 |issue= 10 |pages= 2544-55 |year= 2004 |pmid= 14514732 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Uutela M, Wirzenius M, Paavonen K, ''et al.'' |title=PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. |journal=Blood |volume=104 |issue= 10 |pages= 3198-204 |year= 2004 |pmid= 15271796 |doi= 10.1182/blood-2004-04-1485 }}
*{{cite journal   |vauthors=Ray S, Gao C, Wyatt K, etal |title=Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation |journal=J. Biol. Chem. |volume=280 |issue= 9 |pages= 8494–502 |year= 2005 |pmid= 15611105 |doi= 10.1074/jbc.M413570200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Ustach CV, Kim HR |title=Platelet-Derived Growth Factor D Is Activated by Urokinase Plasminogen Activator in Prostate Carcinoma Cells |journal=Mol. Cell. Biol. |volume=25 |issue= 14 |pages= 6279–88 |year= 2005 |pmid= 15988036 |doi= 10.1128/MCB.25.14.6279-6288.2005 | pmc=1168822 }}
*{{cite journal | author=Ray S, Gao C, Wyatt K, ''et al.'' |title=Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation. |journal=J. Biol. Chem. |volume=280 |issue= 9 |pages= 8494-502 |year= 2005 |pmid= 15611105 |doi= 10.1074/jbc.M413570200 }}
*{{cite journal   |vauthors=Liu MY, Eyries M, Zhang C, etal |title=Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1 |journal=Blood |volume=107 |issue= 6 |pages= 2322–9 |year= 2006 |pmid= 16189269 |doi= 10.1182/blood-2005-06-2377 }}
*{{cite journal  | author=Ustach CV, Kim HR |title=Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. |journal=Mol. Cell. Biol. |volume=25 |issue= 14 |pages= 6279-88 |year= 2005 |pmid= 15988036 |doi= 10.1128/MCB.25.14.6279-6288.2005 }}
*{{cite journal | author=Liu MY, Eyries M, Zhang C, ''et al.'' |title=Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1. |journal=Blood |volume=107 |issue= 6 |pages= 2322-9 |year= 2006 |pmid= 16189269 |doi= 10.1182/blood-2005-06-2377 }}
}}
}}
{{refend}}
{{refend}}


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{{Growth factors}}
{{Growth factor receptor modulators}}
 
 
{{gene-11-stub}}

Latest revision as of 14:21, 19 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene.[1][2][3]

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.[3]

References

  1. ↑ Hamada T, Ui-Tei K, Imaki J, Miyata Y (Feb 2001). "Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein". Biochem Biophys Res Commun. 280 (3): 733–7. doi:10.1006/bbrc.2000.4187. PMID 11162582.
  2. ↑ LaRochelle WJ, Jeffers M, Corvalan JR, Jia XC, Feng X, Vanegas S, Vickroy JD, Yang XD, Chen F, Gazit G, Mayotte J, Macaluso J, Rittman B, Wu F, Dhanabal M, Herrmann J, Lichenstein HS (Apr 2002). "Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer". Cancer Res. 62 (9): 2468–73. PMID 11980634.
  3. ↑ 3.0 3.1 "Entrez Gene: PDGFD platelet derived growth factor D".

Further reading



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