Angiopoietin 1

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RefSeq (mRNA)



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Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.[1] During pregnancy, angiopoietins act complimentary to the VEGF system and contribute to endothelial cell survival and the remodeling of vessels. Few studies have examined the role of angiopoietins in human pregnancy complications like preeclampsia and intrauterine growth restriction (IUGR).

A knockout model of ANGPT1 was introduced in mice embryos. Results showed that embryos began to appear abnormal by day 11 and were dead by day 12.5 of pregnancy. The embryos showed prominent defects in endocardial and myocardial development as well as a less complex vascular network.



Angiopoietin 1 has been shown to interact with TEK tyrosine kinase.[4][5][6][7]

Placental Malaria

Recently, studies in malaria-endemic areas suggest that placental malaria (PM) may be associated with a dysregulation in angiopoietins. Increased levels of angiopoietin-1 appear to be associated with a decrease in placental weight and placental barrier thickness in women infected with Plasmodium (the causative agent of malaria).[8] In a mouse model of PM, Plasmodium infection of pregnant mice led to decreased angiopoietin-1, increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta.[9] This suggests that angiopoietin levels could be clinically significant biomarkers to identify mothers infected with PM.

See also


  1. "Entrez Gene: ANGPT1 angiopoietin 1".
  2. Suri, Chitra; Jones, Pamela F; Patan, Sybill; Bartunkova, Sona; Maisonpierre, Peter C; Davis, Samuel; Sato, Thomas N; Yancopoulos, George D (1996). "Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis". Cell. 87 (7): 1171. doi:10.1016/S0092-8674(00)81813-9. PMID 8980224.
  3. Kappou D, Sifakis S, Konstantinidou A, et al. Role of angiopoietin/Tie system in pregnancy.Experimental and Therapeutic Medicine. 2015; 9(4): 1091-1096.
  4. Fiedler, Ulrike; Krissl, Tanja; Koidl, Stefanie; Weiss, Cornelia; Koblizek, Thomas; Deutsch, Urban; Martiny-Baron, Georg; Marmé, Dieter; Augustin, Hellmut G (Jan 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. United States. 278 (3): 1721–7. doi:10.1074/jbc.M208550200. ISSN 0021-9258. PMID 12427764.
  5. Davis, S; Aldrich, T H; Jones, P F; Acheson, A; Compton, D L; Jain, V; Ryan, T E; Bruno, J; Radziejewski, C; Maisonpierre, P C; Yancopoulos, G D (Dec 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell. United States. 87 (7): 1161–9. doi:10.1016/S0092-8674(00)81812-7. ISSN 0092-8674. PMID 8980223.
  6. Sato, A; Iwama A; Takakura N; Nishio H; Yancopoulos G D; Suda T (Aug 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. ENGLAND. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. ISSN 0953-8178. PMID 9723709.
  7. Maisonpierre, P C; Suri, C; Jones, P F; Bartunkova, S; Wiegand, S J; Radziejewski, C; Compton, D; McClain, J; Aldrich, T H; Papadopoulos, N; Daly, T J; Davis, S; Sato, T N; Yancopoulos, G D (Jul 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. UNITED STATES. 277 (5322): 55–60. doi:10.1126/science.277.5322.55. ISSN 0036-8075. PMID 9204896.
  8. Ataíde, Ricardo; Murillo, Oscar; Dombrowski, Jamille G.; Souza, Rodrigo M.; Lima, Flávia A.; Lima, Giselle F. M. C.; Hristov, Angélica D.; Valle, Suiane C. N.; Santi, Silvia M. Di (2015-06-19). "Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta". PLOS Neglected Tropical Diseases. 9 (6): e0003824. doi:10.1371/journal.pntd.0003824. ISSN 1935-2735. PMC 4475015. PMID 26090803.
  9. Silver, Karlee L.; Zhong, Kathleen; Leke, Rose G. F.; Taylor, Diane Wallace; Kain, Kevin C. (2010-03-01). "Dysregulation of angiopoietins is associated with placental malaria and low birth weight". PLoS One. 5 (3): e9481. Bibcode:2010PLoSO...5.9481S. doi:10.1371/journal.pone.0009481. ISSN 1932-6203. PMC 2830425. PMID 20208992.

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.