Osteoarthritis differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Differentiating Osteoarthritis from other Diseases

Diseases which can have similar symptoms are

Diagnoses of arthritis are largely clinical, but laboratory tests such as ANA, erythrocyte sedimentation rate, C-reactive protein can help differentiate osteoarthritis from an inflammatory cause of arthritis.

Disease Differentiating signs and symptoms Diagnostic findings
Fibromyalgia
  • All lab tests are normal
Rheumatoid arthritis
  • Markers of systemic inflammation (ESR, CRP) are typically elevated.
SLE
Chronic fatigue syndrome Fatigue plus 4 of the following symptoms:
  • Diagnosis of exclusions
  • Symptoms must present for more than 6 months
Spondyloarthritis
Polymyalgia rheumatica
Osteoarthritis
  • Localized joint pain
  • Restricted to affect joints
  • Older at onset
  • X-ray of the involved joints demonstrate degenerative changes
Hypothyroidism
  • TSH is elevated and free T4 is low.
Myopathaies (polymyositis and dermatomyositis)
Neuropathy

References

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