Nordazepam: Difference between revisions

Nordazepam
	File:Nordazepam.svg
Clinical data
Pregnancy; category	?;
Routes of; administration	Oral
ATC code	N05BA16 (WHO) ;
Legal status
Legal status	Schedule IV(US);
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Elimination half-life	50-120 hours
Excretion	Renal
Identifiers
	IUPAC name 9-chloro-6-phenyl-; 2,5-diazabicyclo[5.4.0]undeca-; 5,8,10,12-tetraen-3-one;
CAS Number	1088-11-5;
PubChem CID	2997;
DrugBank	none;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C15H11ClN2O
Molar mass	270.71

Revision as of 18:55, 27 September 2011

Nordazepam (marketed under brand names Stilny®, Madar®, Vegesan®, and Calmday®), also known as nordiazepam and desmethyldiazepam, is a 1,4-benzodiazepine derivative. Like other benzodiazepine derivatives, it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties. However, it is used primarily in the treatment of anxiety. It is an active metabolite of diazepam, chlordiazepoxide, clorazepate, prazepam, and medazepam.^[1]

Side effects

Common side effects of nordazepam include somnolence, which is more common in elderly patients and/or people on high dose regimens. Hypotonia, which is much less common, is also associated with high doses and/or old age.

Interactions

Benzodiazepines including N-desmethyldiazepam (nordazepam) may inhibit the glucuronidation of morphine leading to increased levels of and prolongation of the effects of morphine.^[2]

Abuse

Nordazepam and other sedative hypnotic drugs are detected frequently in cases of people suspected of driving under the influence of drugs. Other benzodiazepines and zolpidem and zopiclone are also found in high numbers of suspected drugged drivers. Many drivers have blood levels far exceeding the therapeutic dose range suggesting a high degree of abuse potential for benzodiazepines and zolpidem and zopiclone.^[3]

External links

Inchem - Nordazepam

References

↑ Biam. "NORDAZEPAM" (in French). Retrieved 18 October. Unknown parameter |refyear= ignored (help); Unknown parameter |accessyear= ignored (|access-date= suggested) (help); Check date values in: |accessdate= (help)
↑ Pacifici GM (1986). "Metabolic interaction between morphine and various benzodiazepines". Acta Pharmacol Toxicol (Copenh). 58 (4): 249–52. PMID 2872767. Unknown parameter |coauthors= ignored (help); Unknown parameter |month= ignored (help)
↑ Jones AW (2007). "Concentrations of scheduled prescription drugs in blood of impaired drivers: considerations for interpreting the results". Ther Drug Monit. 29 (2): 248–60. PMID 17417081. Unknown parameter |coauthors= ignored (help); Unknown parameter |month= ignored (help)

Template:Benzodiazepines Template:Anxiolytics

Template:Pharma-stub sv:Nordazepam

[what_from-1] Biam. "NORDAZEPAM" (in French). Retrieved 18 October. Unknown parameter |refyear= ignored (help); Unknown parameter |accessyear= ignored (|access-date= suggested) (help); Check date values in: |accessdate= (help)

[2] Pacifici GM (1986). "Metabolic interaction between morphine and various benzodiazepines". Acta Pharmacol Toxicol (Copenh). 58 (4): 249–52. PMID 2872767. Unknown parameter |coauthors= ignored (help); Unknown parameter |month= ignored (help)

[3] Jones AW (2007). "Concentrations of scheduled prescription drugs in blood of impaired drivers: considerations for interpreting the results". Ther Drug Monit. 29 (2): 248–60. PMID 17417081. Unknown parameter |coauthors= ignored (help); Unknown parameter |month= ignored (help)

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