Non-alcoholic fatty liver disease historical perspective: Difference between revisions

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==Overview==
==Overview==
NAFLD/NASH was first described in a 1980 series of [[obese]], non-alcoholic patients of the [[Mayo Clinic]].<ref>Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc. 1980;55:434-438. PMID 7382552.</ref> Since that seminal description, our understanding of [[NAFLD]] has progressed minimally. <ref>Day, CP. Non-alcoholic steatohepatitis (NASH): where are we now and where are we going? Gut. 2002 May; 50(5): 585–588.</ref>The significance of NAFLD cannot be overstated. It parallels the obesity epidemic inside the US and is the most common hepatic disorder within the western hemisphere. currently the third leading indication for liver transplant, by 2030, non-alcoholic steatohepatitis (NASH) is expected to become the maximum not unusual motive for transplantation in the US. With an explosion of novel healing procedures for hepatitis C virus and a relative paucity of remedy alternatives for the spectrum of fatty liver disease, plenty interest has grew to become closer to development of NASH disorder-modifying agents and noninvasive diagnostic equipment.<ref name="pmid285079292">{{cite journal |vauthors=Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J |title=Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies |journal=J Clin Transl Hepatol |volume=5 |issue=1 |pages=67–75 |year=2017 |pmid=28507929 |pmc=5411359 |doi=10.14218/JCTH.2016.00061 |url=}}</ref>
Ludwig was the first physician to describe the non-alcoholic fatty liver disease as a separate medical entity from other fatty liver diseases.


==Historical Perspective==
==Historical Perspective==


*First introduced in 1980, NAFLD is a quite new concept. <ref name="pmid28507929">{{cite journal |vauthors=Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J |title=Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies |journal=J Clin Transl Hepatol |volume=5 |issue=1 |pages=67–75 |year=2017 |pmid=28507929 |pmc=5411359 |doi=10.14218/JCTH.2016.00061 |url=}}</ref>
*In 1980, Ludwig was the first physician to describe non-alcoholic fatty liver disease as a separate medical entity from other fatty liver diseases.<ref name="pmid28507929">{{cite journal |vauthors=Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J |title=Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies |journal=J Clin Transl Hepatol |volume=5 |issue=1 |pages=67–75 |year=2017 |pmid=28507929 |pmc=5411359 |doi=10.14218/JCTH.2016.00061 |url=}}</ref><ref name="pmid285079292">{{cite journal |vauthors=Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J |title=Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies |journal=J Clin Transl Hepatol |volume=5 |issue=1 |pages=67–75 |year=2017 |pmid=28507929 |pmc=5411359 |doi=10.14218/JCTH.2016.00061 |url=}}</ref><ref name="pmid7382552">{{cite journal |vauthors=Ludwig J, Viggiano TR, McGill DB, Oh BJ |title=Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease |journal=Mayo Clin. Proc. |volume=55 |issue=7 |pages=434–8 |year=1980 |pmid=7382552 |doi= |url=}}</ref>
*It is divided into non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) primarily based on histologic findings.
*In 1983, Adler & Schaffner described the association between obesity and  non-alcoholic fatty liver disease.
*Biopsies of NAFL may also display macrovesicular steatosis with lobular and periportal irritation however do now not display cellular injury and fibrosis (steatohepatitis), which characterizes NASH. <ref name="pmid28297791">{{cite journal |vauthors=Zhao ZH, Liu XL, Fan JG |title=[Research on the natural history of non-alcoholic fatty liver disease should be taken seriously] |language=Chinese |journal=Zhonghua Gan Zang Bing Za Zhi |volume=25 |issue=2 |pages=81–84 |year=2017 |pmid=28297791 |doi= |url=}}</ref>
*In 1984, Andersen & Gluud conducted numerous experiments with extensive documentation of the liver biopsies in patients with non-alcoholic fatty liver disease.
*NAFL has in large part been taken into consideration benign, but recent cohort studies display a high hazard for development to NASH in as much as 44% on serial biopsies at 5 years.
*In 1985, Bockus was the first to coin the term non-alcoholic fatty liver.
*NASH reasons modern fibrosis which could result in cirrhosis and hepatocellular cancer (HCC).


==References==
==References==

Latest revision as of 00:34, 28 December 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

Ludwig was the first physician to describe the non-alcoholic fatty liver disease as a separate medical entity from other fatty liver diseases.

Historical Perspective

  • In 1980, Ludwig was the first physician to describe non-alcoholic fatty liver disease as a separate medical entity from other fatty liver diseases.[1][2][3]
  • In 1983, Adler & Schaffner described the association between obesity and non-alcoholic fatty liver disease.
  • In 1984, Andersen & Gluud conducted numerous experiments with extensive documentation of the liver biopsies in patients with non-alcoholic fatty liver disease.
  • In 1985, Bockus was the first to coin the term non-alcoholic fatty liver.

References

  1. Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J (2017). "Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies". J Clin Transl Hepatol. 5 (1): 67–75. doi:10.14218/JCTH.2016.00061. PMC 5411359. PMID 28507929.
  2. Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J (2017). "Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies". J Clin Transl Hepatol. 5 (1): 67–75. doi:10.14218/JCTH.2016.00061. PMC 5411359. PMID 28507929.
  3. Ludwig J, Viggiano TR, McGill DB, Oh BJ (1980). "Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease". Mayo Clin. Proc. 55 (7): 434–8. PMID 7382552.

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