Non-alcoholic fatty liver disease Noninvasive scores
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
FIB-4 index at MedCalc and https://www.hepatitisc.uw.edu/page/clinical-calculators/fib-4 . For assessing need for biopsy in hepatitis B and hepatitis C.
NAFLD fibrosis score MedCalc APRI MedCalc
The LiverRisk score *https://www.liverriskscore.com/) may be more accurate than the FIB-4 or aspartate transferase to platelet ratio index (APRI) at repdicting liver stiffness measurements of 6 kPa or more, 10 kPa or more, and 15 kPa[1]. These kPa thresholds correspond to:
- 6 kPa: no fibrosis
- 10 kPa: between F3 and F4 fibrosis
- 15 kPa: above F4 fibrosis
"LS of 8 and 12.5 kPa represent generally accepted cut-off values for F3 and F4 fibrosis. LS highly correlates with portal pressure, and esophageal varices are likely at values >20 kPa."[2]
A newer score is the NAFLD-MESA Index[3]
References
- ↑ Serra-Burriel M, Juanola A, Serra-Burriel F, Thiele M, Graupera I, Pose E; et al. (2023). "Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study". Lancet. doi:10.1016/S0140-6736(23)01174-1. PMID 37572680 Check
|pmid=value (help). - ↑ Mueller S, Sandrin L (2010). "Liver stiffness: a novel parameter for the diagnosis of liver disease". Hepat Med. 2: 49–67. doi:10.2147/hmer.s7394. PMC 3846375. PMID 24367208.
- ↑ Rodriguez, L.A., Shiboski, S.C., Bradshaw, P.T. et al. Predicting Non-Alcoholic Fatty Liver Disease for Adults Using Practical Clinical Measures: Evidence from the Multi-ethnic Study of Atherosclerosis. J GEN INTERN MED 36, 2648–2655 (2021). https://doi.org/10.1007/s11606-020-06426-5