Nephrotic syndrome classification: Difference between revisions

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|-
|-
! rowspan="6" align="center" style="background:#DCDCDC;" + |Podocytopathies
! rowspan="6" align="center" style="background:#DCDCDC;" + |Podocytopathies
| rowspan="2" |Primary  
| rowspan="2" align="left" style="background:#F5F5F5;" + |Primary  
|[[Minimal change disease]]
| align="left" style="background:#F5F5F5;" + |[[Minimal change disease]]
|-
|-
|[[Focal segmental glomerulosclerosis]] ([[Focal segmental glomerulosclerosis|FSGS]])
| align="left" style="background:#F5F5F5;" + |[[Focal segmental glomerulosclerosis]] ([[Focal segmental glomerulosclerosis|FSGS]])
|-
|-
| rowspan="4" |Secondary
| rowspan="4" align="left" style="background:#F5F5F5;" + |Secondary
|Infection such as:  
| align="left" style="background:#F5F5F5;" + |Infection such as:  
* [[Human Immunodeficiency Virus (HIV)|HIV]]
* [[Human Immunodeficiency Virus (HIV)|HIV]]
|-
|-
|Drugs/toxins such as:
| align="left" style="background:#F5F5F5;" + |Drugs/toxins such as:
* [[Non-steroidal anti-inflammatory drug|NSAIDs]]
* [[Non-steroidal anti-inflammatory drug|NSAIDs]]
* Interferon
* Interferon
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* Envenomation
* Envenomation
|-
|-
|Malignancies such as:
| align="left" style="background:#F5F5F5;" + |Malignancies such as:
* [[Hodgkin's lymphoma|Hodgkin lymphoma]]
* [[Hodgkin's lymphoma|Hodgkin lymphoma]]
* [[Thymoma]]
* [[Thymoma]]
|-
|-
|Genetic disorders such as:  
| align="left" style="background:#F5F5F5;" + |Genetic disorders such as:  
* [[Nephrin]] mutations
* [[Nephrin]] mutations
* [[Podocin]] gene mutations
* [[Podocin]] gene mutations
|-
|-
! rowspan="2" align="center" style="background:#DCDCDC;" + |Membranous glomerulonephritis
! rowspan="2" align="center" style="background:#DCDCDC;" + |Membranous glomerulonephritis
|Primary  
| align="left" style="background:#F5F5F5;" + |Primary  
|[[Membranous nephritis|Membranous nephropathy]]
| align="left" style="background:#F5F5F5;" + |[[Membranous nephritis|Membranous nephropathy]]
|-
|-
|Secondary
| align="left" style="background:#F5F5F5;" + |Secondary
|
| align="left" style="background:#F5F5F5;" + |
* [[Drugs]]
* [[Drugs]]
* [[Toxin|Toxins]]
* [[Toxin|Toxins]]
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|-
|-
! align="center" style="background:#DCDCDC;" + |Membranoproliferative glomerulonephritis
! align="center" style="background:#DCDCDC;" + |Membranoproliferative glomerulonephritis
|Secondary
| align="left" style="background:#F5F5F5;" + |Secondary
|
| align="left" style="background:#F5F5F5;" + |
* Autoimmune disorders such as:
* Autoimmune disorders such as:
** [[SLE]]
** [[SLE]]
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|-
|-
! align="center" style="background:#DCDCDC;" + |Hereditary Nephropathy
! align="center" style="background:#DCDCDC;" + |Hereditary Nephropathy
| colspan="2" |
| colspan="2" align="left" style="background:#F5F5F5;" + |
* [[Alport syndrome]]
* [[Alport syndrome]]
* [[IgA nephropathy]]
* [[IgA nephropathy]]
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|-
|-
! align="center" style="background:#DCDCDC;" + |Glomerular deposition diseases
! align="center" style="background:#DCDCDC;" + |Glomerular deposition diseases
| colspan="2" |
| colspan="2" align="left" style="background:#F5F5F5;" + |
* [[Diabetes mellitus]]
* [[Diabetes mellitus]]
* [[Amyloidosis]]
* [[Amyloidosis]]
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|-
|-
! align="center" style="background:#DCDCDC;" + |Other lesions
! align="center" style="background:#DCDCDC;" + |Other lesions
| colspan="2" |
| colspan="2" align="left" style="background:#F5F5F5;" + |
* [[Fabry's disease|Fabry disease]]
* [[Fabry's disease|Fabry disease]]
* [[Nail-patella syndrome]]
* [[Nail-patella syndrome]]

Revision as of 00:55, 29 July 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3] Yazan Daaboul,

Serge Korjian

Overview

Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology. Primary (idiopathic) nephrotic syndrome is defined as nephrotic syndrome due to a primary glomerular disease. Secondary nephrotic syndrome is defined as nephrotic syndrome due to a primary etiology other than glomerular disorders, such as infections, malignancies, systemic conditions, and medications.

Classification

  • Nephrotic syndrome can be classified into primary or secondary depending on the underlying etiology.[1]
 
 
 
Nephrotic
syndrome
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Primary
 
 
 
Secondary
  • Below table lists different types of nephrotic syndromes:[2][3][4]
Different types of nephrotic syndromes Disease name
Podocytopathies Primary Minimal change disease
Focal segmental glomerulosclerosis (FSGS)
Secondary Infection such as:
Drugs/toxins such as:
  • NSAIDs
  • Interferon
  • Pamidronate
  • Lithium
  • Vaccins
  • Envenomation
Malignancies such as:
Genetic disorders such as:
Membranous glomerulonephritis Primary Membranous nephropathy
Secondary
Membranoproliferative glomerulonephritis Secondary
Hereditary Nephropathy
Glomerular deposition diseases
Other lesions

References

  1. Kodner C (2009). "Nephrotic syndrome in adults: diagnosis and management". Am Fam Physician. 80 (10): 1129–34. PMID 19904897.
  2. Braden GL, Mulhern JG, O'Shea MH, Nash SV, Ucci AA, Germain MJ (May 2000). "Changing incidence of glomerular diseases in adults". Am. J. Kidney Dis. 35 (5): 878–83. PMID 10793022.
  3. Heaf J (September 2004). "The Danish Renal Biopsy Register". Kidney Int. 66 (3): 895–7. doi:10.1111/j.1523-1755.2004.00832.x. PMID 15327377.
  4. Ha TS (March 2017). "Genetics of hereditary nephrotic syndrome: a clinical review". Korean J Pediatr. 60 (3): 55–63. doi:10.3345/kjp.2017.60.3.55. PMC 5383633. PMID 28392820.

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