Mucoepidermoid carcinoma pathophysiology

Jump to navigation Jump to search

Mucoepidermoid carcinoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Mucoepidermoid Carcinoma from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Mucoepidermoid carcinoma pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Mucoepidermoid carcinoma pathophysiology

All Images
X-rays
Echo and Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Mucoepidermoid carcinoma pathophysiology

CDC on Mucoepidermoid carcinoma pathophysiology

Mucoepidermoid carcinoma pathophysiology in the news

Blogs on Mucoepidermoid carcinoma pathophysiology

Directions to Hospitals Treating Mucoepidermoid carcinoma

Risk calculators and risk factors for Mucoepidermoid carcinoma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Mucoepidermoid carcinomas arise from mucous cells, which is normally involved in the secretion of mucous and the protection of surrounding tissue. The pathogenesis of mucoepidermoid carcinoma consists of abnormal production of mucin from mucous cells, associated with the aberrant overgrowth of squamous and epidermoid cells. Genes involved in the pathogenesis of mucoepidermoid carcinoma include MECT1 and MAML2 fusion genes. On gross pathology, mucoepidermoid carcinomas have a cystic, solid or mixed appearance, the tumor size ranges from 1 to 8 cm, and they are normally located on the parotid or submandibular gland.[1] On microscopic histopathological analysis, mucoepidermoid carcinomas are characterized by mucous cells with abundant fluffy cytoplasm and large mucin vacuoles.[1]

Pathogenesis

  • Mucoepidermoid carcinomas arise from mucous cells, which are normally involved in the secretion of mucous and the protection of the surrounding tissue.
  • The pathogenesis of mucoepidermoid carcinoma consists of abnormal production of mucin from mucous cells, associated with the aberrant overgrowth of squamous and epidermoid cells.

Genetics

  • Development of mucoepidermoid carcinomas may be the result of multiple genetic mutations.
  • Genes involved in the pathogenesis of include:

Associated Conditions

  • Mucoepidermoid carcinomas have no associated conditions.

Gross Pathology

  • On gross pathology, mucoepidermoid carcinoma has a cystic, solid or mixed appearance.
  • Other gross pathology findings, include:
  • The tumor size ranges from 1 to 8 cm
  • Normally located on the parotid or submandibular gland
  • Gray or white color, with mucin filled cysts

Microscopic Pathology

  • On microscopic histopathological analysis, the characteristic feature of mucoepidermoid carcinomas, include:
  • Mucus secreting cells (visible with musicarmine staining)
  • Composed of three cell types: epidermoid, intermediate, and mucin producing
  • Mucin vacuoles may be rare; in a superficial glance (mimics squamous cell carcinoma)
  • Mucoepidermoid tumors are graded histologically into: low grade, intermediate grade, and high grade.
  • Low grade is characterized by well-differentiated cells with little cellular atypia, high proportion of mucous cells, and prominent cyst formation
  • Intermediate grade is characterized by intermediate features
  • High grade is characterized by poorly differentiated with cellular pleomorphism, high proportion of squamous cells, and solid with few if any cysts

Gallery

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Mucoepidermoid carcinoma. Libre Pathology. http://librepathology.org/wiki/index.php/Mucoepidermoid carcinoma Accessed on February 17, 2015


Template:WikiDoc Sources