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==Historical Perspective==
==Historical Perspective==
9000 year old skulls exist with evidence of [[trepanation]]. It is hypothesized that this drastic step was taken in response to headaches, though there is no clear evidence proving this. Headache with [[neuralgia]] was recorded in the medical documents of the ancient Egyptians as early as 1200 BC. In 400 BC [[Hippocrates]] described the visual [[aura (symptom)|aura]] that can precede the migraine headache and the relief which can occur through vomiting. Aretaeus of Cappadocia is credited as the "discoverer" of migraines because of his second century description of the symptoms of a unilateral headache associated with vomiting, with headache-free intervals in between attacks. Galenus of Pergamon used the term "hemicrania" (half-head), from which the word "migraine" was derived. He thought there was a connection between the [[stomach]] and the brain because of the nausea and vomiting that often accompany an attack. For relief of migraine, Spanish-born physician [[Abulcasis]], also known as Abu El Quasim, suggested application of a hot iron to the head or insertion of garlic into an incision made in the temple. In the Medieval Ages migraine was recognized as a discrete medical disorder with treatment ranging from hot irons to blood letting and even witchcraft. Followers of Galenus explained migraine as caused by aggressive [[yellow bile]]. Ebn Sina ([[Avicenna]]) described migraine in his textbook "El Qanoon fel teb" as "... small movements, drinking and eating, and sounds provoke the pain... the patient cannot tolerate the sound of speaking and light. He would like to rest in darkness alone." Abu Bakr Mohamed Ibn Zakariya Râzi noted the association of headache with different events in the lives of women, "...And such a headache may be observed after delivery and [[abortion]] or during [[menopause]] and [[dysmenorrhea]]. " In ''Bibliotheca Anatomica, Medic, Chirurgica'', published in London in 1712, five major types of headaches are described, including the "Megrim", recognizable as classic migraine. Graham and Wolff (1938) published their paper advocating [[ergotamine]] tart for relieving migraine. Later in the 20th century, Harold Wolff (1950) developed the experimental approach to the study of headache and elaborated the vascular theory of migraine, which has come under attack as the pendulum again swings to the neurogenic theory.
An early description consistent with migraines is contained in the [[Ebers papyrus]], written around 1500&nbsp;BCE in ancient Egypt.<ref name=Miller2005>{{cite book|last=Miller|first=Neil|title=Walsh and Hoyt's clinical neuro-ophthalmology.|year=2005|publisher=Lippincott Williams & Wilkins|location=Philadelphia, Pa.|isbn=9780781748117|pages=1275|url=http://books.google.ca/books?id=9RA2ZOPRuhgC&pg=PA1275|edition=6}}</ref> In 200 BCE, writings from the [[Hippocrates|Hippocratic school of medicine]] described the visual aura that can precede the headache and a partial relief occurring through vomiting.<ref name=Borsook2012>{{cite book|last=Borsook|first=David|title=The migraine brain : imaging, structure, and function|year=2012|publisher=Oxford University Press|location=New York|isbn=9780199754564|pages=3–11|url=http://books.google.ca/books?id=5GVVJS_fCAkC&pg=PA3&lpg=PA3}}</ref>  A second-century description by [[Aretaeus of Cappadocia]] divided headaches into three types: cephalalgia, cephalea, and heterocrania.<ref name=Waldman2011>{{cite book|last=Waldman|first=[edited by] Steven D.|title=Pain management|year=2011|publisher=Elsevier/Saunders|location=Philadelphia, PA|isbn=9781437736038|pages=2122–2124|url=http://books.google.ca/books?id=O6AojTbeXoEC&pg=PT2122&lpg=PT2122|edition=2}}</ref> [[Galen|Galen of Pergamon]] used the term hemicrania (half-head), from which the word migraine was eventually derived.<ref name=Waldman2011/> He also proposed that the pain arose from the meninges and blood vessels of the head.<ref name=Borsook2012/> Migraines were first divided into the two now used types - migraine with aura (''migraine ophthalmique'') and migraine without aura (''migraine vulgaire'') in 1887 by Louis Hyacinthe Thomas, a French Librarian.<ref name=Borsook2012/>
 
[[Trepanation]], the deliberate drilling of holes into a skull, was practiced as early as 7,000&nbsp;BCE.<ref name=Miller2005/> While sometimes people survived, many would have died from the procedure due to infection.<ref>{{cite book|last=Mays|first=eds. Margaret Cox, Simon|title=Human osteology : in archaeology and forensic science|year=2002|publisher=Cambridge University Press|location=Cambridge [etc.]|isbn=9780521691468|pages=345|url=http://books.google.ca/books?id=-UqAnk-n7wgC&pg=PA345|edition=Repr.}}</ref> It was believed to work via "letting evil spirits escape".<ref>{{cite book|last=Colen|first=Chaim|title=Neurosurgery|year=2008|publisher=Colen Publishing|isbn=9781935345039|pages=1|url=http://books.google.ca/books?id=zHg53Gw0JrAC&pg=PA1}}</ref> [[William Harvey]] recommended trepanation as a treatment for migraines in the 17th century.<ref>{{cite book|last=Daniel|first=Britt Talley|title=Migraine|year=2010|publisher=AuthorHouse|location=Bloomington, IN|isbn=9781449069629|pages=101|url=http://books.google.ca/books?id=YSoSECeCudIC&pg=PA101&lpg=PA101}}</ref>
 
While many treatments for migraines have been attempted, it was not until 1868 that use of a substance which eventually turned out to be effective began.<ref name=Borsook2012/> This substance was the fungus [[ergot]] from which ergotamine was isolated in 1918.<ref name=Hanson2011>{{cite journal|last=Tfelt-Hansen|first=PC|coauthors=Koehler, PJ|title=One hundred years of migraine research: major clinical and scientific observations from 1910 to 2010|journal=Headache|date=May 2011|volume=51|issue=5|pages=752–78|pmid=21521208|doi=10.1111/j.1526-4610.2011.01892.x}}</ref> [[Methysergide]] was developed in 1959 and the first triptan, [[sumatriptan]], was developed in 1988.<ref name=Hanson2011/> During the 20th century with better study design effective preventative measures were found and confirmed.<ref name=Borsook2012/>
 
Shown below is an image depicting a trepanated skull, from the [[Neolithic]]. The perimeter of the hole in the skull is rounded off by ingrowth of new bony tissue, indicating that the person survived the operation.
 
[[Image:Crane-trepanation-img 0507 crop.jpg]]


==References==
==References==

Revision as of 20:46, 7 February 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The word migraine is French in origin and comes from the Greek hemicrania, as does the Old English term megrim. Literally, hemicrania means "half (the) head".

Historical Perspective

An early description consistent with migraines is contained in the Ebers papyrus, written around 1500 BCE in ancient Egypt.[1] In 200 BCE, writings from the Hippocratic school of medicine described the visual aura that can precede the headache and a partial relief occurring through vomiting.[2] A second-century description by Aretaeus of Cappadocia divided headaches into three types: cephalalgia, cephalea, and heterocrania.[3] Galen of Pergamon used the term hemicrania (half-head), from which the word migraine was eventually derived.[3] He also proposed that the pain arose from the meninges and blood vessels of the head.[2] Migraines were first divided into the two now used types - migraine with aura (migraine ophthalmique) and migraine without aura (migraine vulgaire) in 1887 by Louis Hyacinthe Thomas, a French Librarian.[2]

Trepanation, the deliberate drilling of holes into a skull, was practiced as early as 7,000 BCE.[1] While sometimes people survived, many would have died from the procedure due to infection.[4] It was believed to work via "letting evil spirits escape".[5] William Harvey recommended trepanation as a treatment for migraines in the 17th century.[6]

While many treatments for migraines have been attempted, it was not until 1868 that use of a substance which eventually turned out to be effective began.[2] This substance was the fungus ergot from which ergotamine was isolated in 1918.[7] Methysergide was developed in 1959 and the first triptan, sumatriptan, was developed in 1988.[7] During the 20th century with better study design effective preventative measures were found and confirmed.[2]

Shown below is an image depicting a trepanated skull, from the Neolithic. The perimeter of the hole in the skull is rounded off by ingrowth of new bony tissue, indicating that the person survived the operation.

References

  1. 1.0 1.1 Miller, Neil (2005). Walsh and Hoyt's clinical neuro-ophthalmology (6 ed.). Philadelphia, Pa.: Lippincott Williams & Wilkins. p. 1275. ISBN 9780781748117.
  2. 2.0 2.1 2.2 2.3 2.4 Borsook, David (2012). The migraine brain : imaging, structure, and function. New York: Oxford University Press. pp. 3–11. ISBN 9780199754564.
  3. 3.0 3.1 Waldman, [edited by] Steven D. (2011). Pain management (2 ed.). Philadelphia, PA: Elsevier/Saunders. pp. 2122–2124. ISBN 9781437736038.
  4. Mays, eds. Margaret Cox, Simon (2002). Human osteology : in archaeology and forensic science (Repr. ed.). Cambridge [etc.]: Cambridge University Press. p. 345. ISBN 9780521691468.
  5. Colen, Chaim (2008). Neurosurgery. Colen Publishing. p. 1. ISBN 9781935345039.
  6. Daniel, Britt Talley (2010). Migraine. Bloomington, IN: AuthorHouse. p. 101. ISBN 9781449069629.
  7. 7.0 7.1 Tfelt-Hansen, PC (May 2011). "One hundred years of migraine research: major clinical and scientific observations from 1910 to 2010". Headache. 51 (5): 752–78. doi:10.1111/j.1526-4610.2011.01892.x. PMID 21521208. Unknown parameter |coauthors= ignored (help)

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