Metoprolol: Difference between revisions

Metoprolol
Clinical data
Trade names	Lopressor, Toprol-xl
AHFS/Drugs.com	Monograph
MedlinePlus	a682864
[[Regulation of therapeutic goods \|Template:Engvar data]]	US FDA: Metoprolol;
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	Oral, IV
ATC code	C07AB02 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	12%
Metabolism	Hepatic via CYP2D6, CYP3A4
Elimination half-life	3-7 hours
Excretion	Renal
Identifiers
	IUPAC name (RS)-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol;
CAS Number	51384-51-1 ;
PubChem CID	4171;
IUPHAR/BPS	553;
DrugBank	DB00264 ;
ChemSpider	4027 ;
UNII	GEB06NHM23;
KEGG	D02358 ;
ChEBI	CHEBI:6904 ;
ChEMBL	ChEMBL13 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C15H25NO3
Molar mass	267.364 g/mol
3D model (JSmol)	Interactive image;
Melting point	120 °C (248 °F)
	SMILES O(c1ccc(cc1)CCOC)CC(O)CNC(C)C;
	InChI InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3 ; Key:IUBSYMUCCVWXPE-UHFFFAOYSA-N ;
(verify)

VisualWikitext

Revision as of 13:15, 20 March 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms / Brand Names: Lopressor, Toprol XL

Overview

Metoprolol is a competitive, β₁-selective (cardioselective) blocker used in treatment of angina pectoris, hypertension, arrhythmia, and migraine. Common adverse reactions include bradyarrhythmia, heart block, heart failure, hypotension, pruritus, rash, constipation, diarrhea, indigestion, nausea, dizziness, fatigue, headache, depression, dyspnea, and wheezing.

The active substance metoprolol is employed either as metoprolol succinate or as metoprolol tartrate (where 100 mg metoprolol tartrate corresponds to 95 mg metoprolol succinate). The tartrate is an immediate-release and the succinate is an extended-release formulation.^[1]

Prescribing Information

Lopressor (metoprolol tartrate) tablet

Toprol XL (metoprolol succinate) tablet, extended release

References

↑ Cupp M (2009). "Alternatives for Metoprolol Succinate" (pdf). Pharmacist's Letter / Prescriber's Letter. 25 (250302).

[1] Cupp M (2009). "Alternatives for Metoprolol Succinate" (pdf). Pharmacist's Letter / Prescriber's Letter. 25 (250302).

[1]

@@ Line 6: / Line 6: @@
 ==Overview==
-Metoprolol is a competitive, β<sub>1</sub>-selective (cardioselective) blocker used in treatment of several diseases of the [[cardiovascular system]], especially [[hypertension]]. The active substance metoprolol is employed either as ''metoprolol [[succinic acid|succinate]]'' or as ''metoprolol [[tartrate]]'' (where 100 mg metoprolol [[tartrate]] corresponds to 95 mg metoprolol [[succinic acid|succinate]]). The [[tartrate]] is an immediate-release and the [[succinic acid|succinate]] is an extended-release [[Pharmaceutical formulation|formulation]].<ref>{{cite journal | author = Cupp M | title = Alternatives for Metoprolol Succinate | journal = Pharmacist's Letter / Prescriber's Letter | year = 2009 | volume = 25 | issue = 250302 | url = http://www.ncbop.org/PDF/MetoprololShortageMarch2009.pdf | format = pdf | accessdate = }}</ref>
+Metoprolol is a competitive, [[Beta-1 adrenergic receptor|β<sub>1</sub>]]-selective (cardioselective) [[beta blocker|blocker]] used in treatment of [[angina pectoris]], [[hypertension]], [[arrhythmia]], and [[migraine]]. Common [[adverse reactions]] include [[bradyarrhythmia]], [[heart block]], [[heart failure]], [[hypotension]], [[pruritus]], [[rash]], [[constipation]], [[diarrhea]], [[indigestion]], [[nausea]], [[dizziness]], [[fatigue]], [[headache]], [[depression]], [[dyspnea]], and [[wheezing]].
+The active substance metoprolol is employed either as ''metoprolol [[succinic acid|succinate]]'' or as ''metoprolol [[tartrate]]'' (where 100 mg metoprolol [[tartrate]] corresponds to 95 mg metoprolol [[succinic acid|succinate]]). The [[tartrate]] is an immediate-release and the [[succinic acid|succinate]] is an extended-release [[Pharmaceutical formulation|formulation]].<ref>{{cite journal | author = Cupp M | title = Alternatives for Metoprolol Succinate | journal = Pharmacist's Letter / Prescriber's Letter | year = 2009 | volume = 25 | issue = 250302 | url = http://www.ncbop.org/PDF/MetoprololShortageMarch2009.pdf | format = pdf | accessdate = }}</ref>
 ==Category==

v t e Beta blockers (C07)
Non-selective β antagonists	Metipranolol • Nadolol • Oxprenolol • Penbutolol • Pindolol • Propranolol • Tertatolol • Timolol • Sotalol
β₁ antagonists (cardioselective)	Atenolol • Acebutolol • Celiprolol • Betaxolol • Bisoprolol • Esmolol • Metoprolol • Nebivolol
Mixed α₁/β antagonists	Carvedilol • Labetalol