Membranoproliferative glomerulonephritis laboratory findings

Jump to navigation Jump to search

Membranoproliferative glomerulonephritis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Membranoproliferative glomerulonephritis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Membranoproliferative glomerulonephritis laboratory findings On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Membranoproliferative glomerulonephritis laboratory findings

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Membranoproliferative glomerulonephritis laboratory findings

CDC on Membranoproliferative glomerulonephritis laboratory findings

Membranoproliferative glomerulonephritis laboratory findings in the news

Blogs on Membranoproliferative glomerulonephritis laboratory findings

Directions to Hospitals Treating Membranoproliferative glomerulonephritis

Risk calculators and risk factors for Membranoproliferative glomerulonephritis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Jogeet Singh Sekhon, M.D. [2]

Overview

MPGN laboratory findings include urinalysis, renal function tests, complete blood counts, complement profile and other diagnostic tests for evaluating the cause of MPGN.

Laboratory Findings

Urinalysis

  • Glomerular hematuria; characterized by dysmorphic red blood cells (RBCs) and RBC casts[1]
  • Proteinuria is almost always present.
  • Urine protein creatinine ratio is a good estimate of 24-hour urinary protein excretion.
  • Nephrotic proteinuria is present in approximately 50% of patients.

Serum chemistries

CBC with differential:

Complement profile -

  • C3 levels are low in about half of the patients.
  • Evidence of activation of the classic pathway of complement (ie, low C4, C2, C1q, B, C3)
  • Terminal complement components C3, C5, C8, and C9 may be low or within the reference range.
  • NFc (C4NeF) or NFt may be present.
  • MPGN type II
  • C3 levels are low in 70-80% of patients.
  • Early and terminal complement components are within the reference range.
  • NFa (C3NeF) is present in more than 70% of patients.
  • MPGN type III
  • C3 levels are decreased in 50% of patients.
  • C1q and C4 levels are within the reference range.
  • Terminal complement components are low, especially if C3 is markedly depressed.
  • NFa is absent and NFt is present in 60-80% of patients.
  • Antistreptolysin-O (ASO) titers may be elevated in as many as 50% of patients at presentation.

References

  1. Sethi S, Fervenza FC (2012). "Membranoproliferative glomerulonephritis--a new look at an old entity". N Engl J Med. 366 (12): 1119–31. doi:10.1056/NEJMra1108178. PMID 22435371.
  2. Rennke HG (1995). "Secondary membranoproliferative glomerulonephritis". Kidney Int. 47 (2): 643–56. PMID 7723253.
  3. Alpers CE, Smith KD (2008). "Cryoglobulinemia and renal disease". Curr Opin Nephrol Hypertens. 17 (3): 243–9. doi:10.1097/MNH.0b013e3282f8afe2. PMID 18408474.

Template:WH Template:WS