Membranoproliferative glomerulonephritis classification

Jump to navigation Jump to search

Membranoproliferative glomerulonephritis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Membranoproliferative glomerulonephritis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Membranoproliferative glomerulonephritis classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Membranoproliferative glomerulonephritis classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Membranoproliferative glomerulonephritis classification

CDC on Membranoproliferative glomerulonephritis classification

Membranoproliferative glomerulonephritis classification in the news

Blogs on Membranoproliferative glomerulonephritis classification

Directions to Hospitals Treating Membranoproliferative glomerulonephritis

Risk calculators and risk factors for Membranoproliferative glomerulonephritis classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ali Poyan Mehr, M.D. [2] Olufunmilola Olubukola M.D.[3]

Overview

Like many forms of glomerulopathies, membranoproliferative glomerulonephritis (glomerulopathy) has been a diagnosis of tissue pathology rather the diagnosis of a specific disease entity. Therefore the term membranoploriferative glomerulonephritis (MPGN) relates to a pattern of glomerular injury which can be caused by many disease states. Historically the nephropathologists divided MPGN into 3 distinctive categories to shed light into what may be causing this type of kidney injury: MPGN type 1: mesangial and subendothelial electron dense deposits MPGN type 2: electron dense material in the glomerular basement membrane MPGN type 3: subepithelial deposits with basement membrane spikes This categorization, however is now out of date. The recognition of several new disorders as the underlying cause of MPGN, and the lack of clinical, prognostic or therapeutic relevance made this categorization less useful. For completeness and to help better accommodate the transition from old to new classification, below both classifications are reviewed. Classification of MPGN based on immunofluorescence microscopy is a result of all advances in the understanding of the pathogenesis of the disease. Based on this advanced techniques, there are three types of MPGN [1]:Immune-complex-mediated MPGN (Type I) ,Complement-mediated MPGN (Type II), Non-Ig/complement-mediated MPGN (Type III)

Classification

MPGN can be classified three types based on immunofluorescence microscopy techniques . [2];

Type I

It is the most common type.

Type II

  • Dense deposits are observed in MPGN type II.
  • Complement mediated

Type III

Type III is very rare

  • It is characterized by a combination of subepithelial deposits, deposits in the mesangium and subendothelial space.
  • There is complex disruption of the glomerular basement membrane with large lucent area.

References

  1. Sethi S, Zand L, Leung N, Smith RJ, Jevremonic D, Herrmann SS; et al. (2010). "Membranoproliferative glomerulonephritis secondary to monoclonal gammopathy". Clin J Am Soc Nephrol. 5 (5): 770–82. doi:10.2215/CJN.06760909. PMC 2863981. PMID 20185597.
  2. Sethi S, Fervenza FC (2011). "Membranoproliferative glomerulonephritis: pathogenetic heterogeneity and proposal for a new classification". Semin Nephrol. 31 (4): 341–8. doi:10.1016/j.semnephrol.2011.06.005. PMID 21839367.

Template:WH Template:WS