Lorazepam (injection)

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Lorazepam (injection)
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]

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Overview

Lorazepam (injection) is a general anesthetic that is FDA approved for the {{{indicationType}}} of anxiety, insomnia, due to anxiety or situational stress, premedication for anesthetic procedure, status epilepticus. Common adverse reactions include neurologic: asthenia (4.2% ), dizziness (6.9% ), sedated (15.9% ), unsteadiness present (3.4%), psychiatric: depression.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

  • Alcohol withdrawal syndrome: 2 mg ORALLY every 6 hr for 4 doses, then 1 mg every 6 hr for 8 doses.
  • Anxiety: initial, 2 to 3 mg/day ORALLY divided into 2 to 3 daily doses.
  • Anxiety: maintenance, 2 to 6 mg/day ORALLY divided into 2 to 3 daily doses; dose may vary from 1 to 10 mg/day.
  • Chemotherapy-induced nausea and vomiting; Prophylaxis: a single dose of 0.025 to 0.05 mg/kg (MAX 4 mg) IM OR IV given slowly (2 mg/min) 30 to 35 min prior to receiving chemotherapy; this dose may be supplemented with oral lorazepam 1 to 2 mg/hr as needed.
  • Insomnia, due to anxiety or situational stress: 2 to 4 mg ORALLY at bedtime.
  • Premedication for anesthetic procedure: 0.05 mg/kg IM (MAX 4 mg) 2 hours before procedure.
  • Premedication for anesthetic procedure: 0.044 mg/kg IV OR 2 mg (whichever is less); MAX dose 0.05 mg/kg IV OR 4 mg (whichever is less) 15 to 20 minutes before the surgical procedure.
  • Sedation: (intermittent) 0.02 to 0.06 mg/kg IV every 2 to 6 hours.
  • Sedation: (continuous infusion) 0.01 to 0.1 mg/kg/hr IV.
  • Status epilepticus: 4 mg IV given slowly at 2 mg/min, may repeat dose in 10 to 15 min if needed; IM dosing may be used, but IV dosing is preferred.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

  • Anxiety
  • Insomnia, due to anxiety or situational stress
  • Premedication for anesthetic procedure.
  • Status epilepticus.

Non–Guideline-Supported Use

  • Agitation - Psychotic disorder
  • Alcohol withdrawal syndrome
  • Chemotherapy-induced nausea and vomiting; Prophylaxis
  • Sedation
  • Seizure
  • Seizure, drug-induced; Prophylaxis

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Lorazepam (injection) FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information about Off-Label Guideline-Supported Use of Lorazepam in pediatric patients.

Non–Guideline-Supported Use

There is limited information about Off-Label Non–Guideline-Supported Use of Lorazepam in pediatric patients.

Contraindications

There is limited information regarding Lorazepam (injection) Contraindications in the drug label.

Warnings

There is limited information regarding Lorazepam (injection) Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Lorazepam (injection) Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Lorazepam (injection) Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Lorazepam (injection) Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Lorazepam (injection) in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Lorazepam (injection) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Lorazepam (injection) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Lorazepam (injection) in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Lorazepam (injection) in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Lorazepam (injection) in geriatric settings.

Gender

There is no FDA guidance on the use of Lorazepam (injection) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Lorazepam (injection) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Lorazepam (injection) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Lorazepam (injection) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Lorazepam (injection) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Lorazepam (injection) in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Lorazepam (injection) Administration in the drug label.

Monitoring

There is limited information regarding Lorazepam (injection) Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Lorazepam (injection) and IV administrations.

Overdosage

There is limited information regarding Lorazepam (injection) overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Lorazepam (injection) Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Lorazepam (injection) Mechanism of Action in the drug label.

Structure

There is limited information regarding Lorazepam (injection) Structure in the drug label.

Pharmacodynamics

There is limited information regarding Lorazepam (injection) Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Lorazepam (injection) Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Lorazepam (injection) Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Lorazepam (injection) Clinical Studies in the drug label.

How Supplied

There is limited information regarding Lorazepam (injection) How Supplied in the drug label.

Storage

There is limited information regarding Lorazepam (injection) Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Lorazepam (injection) Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Lorazepam interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Lorazepam (injection) Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Lorazepam (injection) Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

Synonyms / Brand Names:Almazine, Alzapam, Anxiedin, Aplacassee, Ativan, Bonatranquan, Delormetazepam, Emotival, Idalprem, Lorabenz, Lorax, Loraz, Lorazepam Intensol, Lorsilan, Pro Dorm, Psicopax, Punktyl, Quait, Securit, Sedatival, Sedazin, Somagerol, Tavor, Temesta, Wypax