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ICD-10 R53
ICD-9 780.7

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.

Asthenia (Greek: ασθένεια, lit. lack of strength but also disease) is a medical term denoting a feeling of weakness without actual loss of strength.

Causes of asthenia

Common Causes

Causes by Organ System

Cardiovascular Heart disease
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Chemotherapy, Narcotics, Acamprosate calcium, Adefovir, Aprepitant, Atovaquone-Proguanil, Bicalutamide, Busulfan, Cefaclor, Dalfampridine, Desmopressin, Docetaxel, Efavirenz, Enzalutamide, Eribulin, Eslicarbazepine acetate, Fluvoxamine,Fosfomycin, Fulvestrant, Granisetron, Interferon alfa-2b , Pegylated interferon alfa-2a, Irinotecan hydrochloride, Meropenem, Nabilone, Netupitant and palonosetron, Oxaprozin, Palbociclib, Panitumumab, Perampanel, Pilocarpine, Pyridostigmine, Ribavirin, Ritonavir, Sargramostim, Sunitinib, Temozolomide, Teniposide
Ear Nose Throat No underlying causes
Endocrine Addison's disease, Diabetes, Hypothyroidism,
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic Anemia
Iatrogenic Chemotherapy
Infectious Disease Infections
Musculoskeletal/Orthopedic No underlying causes
Neurologic Chronic fatigue syndrome, Chronic pain, Sleep disorders
Nutritional/Metabolic Diabetes
Obstetric/Gynecologic Pregnancy
Oncologic Chemotherapy, Paraneoplastic syndrome
Ophthalmologic No underlying causes
Overdose/Toxicity Narcotics
Psychiatric Anxiety, Chronic fatigue syndrome, Depression
Pulmonary Pulmonary disease
Renal/Electrolyte Dehydration and electrolyte disturbance, Renal disease,
Rheumatology/Immunology/Allergy Fibromyalgia
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Sedentary lifestyle, Sleep disorders

Causes in Alphabetical Order

See also


  • Adapted from: Hinshaw DB, Carnahan JM, Johnson DL. Depression, anxiety, and asthenia in advanced illness. J Am Coll Surg 2002;195:276.

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