Klinefelter's syndrome medical therapy

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Klinefelter's syndrome Microchapters


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Differentiating Klinefelter's Syndrome from other Diseases

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Medical Therapy


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Medical Therapy

The genetic variation is irreversible, but its symptoms can be altered or treated in a number of ways, including testosterone treatment and other therapies.

Testosterone therapy may be prescribed. This can help:

Inadequately treated hypogonadism in Klinefelter syndrome increases recognized psychosocial morbidity.[1] Often individuals that have noticeable breast tissue or hypogonadism experience depression and/or social anxiety because they are outside of social norms. This is academically referred to as psychosocial morbidity.[1]. At least one study indicates that planned and timed support should be provided for young men with Klinefelter syndrome, to ameliorate current poor psychosocial outcomes.[1]

Delays in motor development can be addressed through occupational therapy.

Most men with this syndrome are not able to father children. However, some men have been able to have children. An infertility specialist may be able to help. By 2010 over 100 successful pregnancies have been reported using IVF technology with surgically removed sperm material from men with Klinefelter syndrome.[2]


  1. 1.0 1.1 1.2 Simm PJ, Zacharin MR. "The psychosocial impact of Klinefelter syndrome--a 10 year review". J Pediatr Endocrinol Metab 2006 Apr;19(4):499-505. PMID 16759035
  2. Fullerton G, Hamilton M, Maheshwari A. (2010). "Should non-mosaic Klinefelter syndrome men be labelled as infertile in 2009?". Hum Reprod. 25 (3): 588–97. doi:10.1093/humrep/dep431. PMID 20085911.

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