IL17RB: Difference between revisions

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{{Infobox_gene}}
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'''Interleukin-17 receptor B''' is a [[protein]] that in humans is encoded by the ''IL17RB'' [[gene]].<ref name="pmid10749887">{{cite journal |vauthors=Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R | title = A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity | journal = J Biol Chem | volume = 275 | issue = 25 | pages = 19167–76 |date=Aug 2000 | pmid = 10749887 | pmc =  | doi = 10.1074/jbc.M910228199 }}</ref><ref name="pmid10815801">{{cite journal |vauthors=Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, ((Shaughnessy JD Jr)) |title=Evi27 encodes a novel membrane protein with homology to the IL17 receptor | journal = Oncogene | volume = 19 | issue = 17 | pages = 2098–109 |date=Jun 2000 | pmid = 10815801 | pmc =  | doi = 10.1038/sj.onc.1203577 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IL17RB interleukin 17 receptor B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55540| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Interleukin 17 receptor B
| HGNCid = 18015
| Symbol = IL17RB
| AltSymbols =; CRL4; EVI27; IL17BR; IL17RH1; MGC5245
| OMIM = 605458
| ECnumber = 
| Homologene = 10287
| MGIid = 1355292
| GeneAtlas_image1 = PBB_GE_IL17RB_219255_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004907 |text = interleukin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
  | Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006952 |text = defense response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55540
    | Hs_Ensembl = ENSG00000056736
    | Hs_RefseqProtein = NP_758434
    | Hs_RefseqmRNA = NM_172234
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 53855612
    | Hs_GenLoc_end = 53874866
    | Hs_Uniprot = Q9NRM6
    | Mm_EntrezGene = 50905
    | Mm_Ensembl = ENSMUSG00000015966
    | Mm_RefseqmRNA = NM_019583
    | Mm_RefseqProtein = NP_062529
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 28825177
    | Mm_GenLoc_end = 28837905
    | Mm_Uniprot = Q543U7
  }}
}}
'''Interleukin 17 receptor B''', also known as '''IL17RB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL17RB interleukin 17 receptor B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55540| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.<ref name="entrez">{{cite web | title = Entrez Gene: IL17RB interleukin 17 receptor B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55540| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a [[cytokine]] [[Receptor (biochemistry)|receptor]]. This receptor specifically binds to [[Interleukin 17B|IL17B]] and [[Interleukin 25|IL17E (IL25)]], but does not bind to [[Interleukin 17|IL17(A)]] or [[IL17C]]. This receptor has been shown to mediate the activation of [[NF-kB|NF-κB]] and the production of [[Interleukin 8|IL8]] induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal [[inflammation]], which suggested the immunoregulatory activity of this receptor.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal  | author=Schwandner R, Yamaguchi K, Cao Z |title=Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. |journal=J. Exp. Med. |volume=191 |issue= 7 |pages= 1233-40 |year= 2000 |pmid= 10748240 |doi=  }}
*{{cite journal  |vauthors=Schwandner R, Yamaguchi K, Cao Z |title=Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. |journal=J. Exp. Med. |volume=191 |issue= 7 |pages= 1233–40 |year= 2000 |pmid= 10748240 |doi=10.1084/jem.191.7.1233  | pmc=2193168  }}
*{{cite journal  | author=Shi Y, Ullrich SJ, Zhang J, ''et al.'' |title=A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 19167-76 |year= 2000 |pmid= 10749887 |doi= 10.1074/jbc.M910228199 }}
*{{cite journal   |vauthors=Lee J, Ho WH, Maruoka M, etal |title=IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 1660–4 |year= 2001 |pmid= 11058597 |doi= 10.1074/jbc.M008289200 }}
*{{cite journal  | author=Tian E, Sawyer JR, Largaespada DA, ''et al.'' |title=Evi27 encodes a novel membrane protein with homology to the IL17 receptor. |journal=Oncogene |volume=19 |issue= 17 |pages= 2098-109 |year= 2000 |pmid= 10815801 |doi= 10.1038/sj.onc.1203577 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Lee J, Ho WH, Maruoka M, ''et al.'' |title=IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 1660-4 |year= 2001 |pmid= 11058597 |doi= 10.1074/jbc.M008289200 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 | pmc=395752 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  |vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal  | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Symmans WF |title=Genomic testing for sensitivity of breast cancer to hormonal therapy. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 1954–5 |year= 2006 |pmid= 16609001 |doi= 10.1158/1078-0432.CCR-06-0289 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Goetz MP, Suman VJ, Ingle JN, etal |title=A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2080–7 |year= 2006 |pmid= 16609019 |doi= 10.1158/1078-0432.CCR-05-1263 }}
*{{cite journal  | author=Symmans WF |title=Genomic testing for sensitivity of breast cancer to hormonal therapy. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 1954-5 |year= 2006 |pmid= 16609001 |doi= 10.1158/1078-0432.CCR-06-0289 }}
*{{cite journal   |vauthors=Ma XJ, Hilsenbeck SG, Wang W, etal |title=The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer. |journal=J. Clin. Oncol. |volume=24 |issue= 28 |pages= 4611–9 |year= 2006 |pmid= 17008703 |doi= 10.1200/JCO.2006.06.6944 }}
*{{cite journal | author=Goetz MP, Suman VJ, Ingle JN, ''et al.'' |title=A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2080-7 |year= 2006 |pmid= 16609019 |doi= 10.1158/1078-0432.CCR-05-1263 }}
*{{cite journal | author=Ma XJ, Hilsenbeck SG, Wang W, ''et al.'' |title=The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer. |journal=J. Clin. Oncol. |volume=24 |issue= 28 |pages= 4611-9 |year= 2006 |pmid= 17008703 |doi= 10.1200/JCO.2006.06.6944 }}
}}
}}
{{refend}}
{{refend}}
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==External links==
==External links==
* {{MeshName|IL17RB+protein,+human}}
* {{MeshName|IL17RB+protein,+human}}
{{NLM content}}
{{Interleukin receptor modulators}}
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[[Category:IL17 family cytokine receptors]]


{{membrane-protein-stub}}
{{membrane-protein-stub}}
{{NLM content}}
[[Category:Cytokine receptors]]
{{WikiDoc Sources}}

Latest revision as of 23:47, 31 August 2017

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SpeciesHumanMouse
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View/Edit Human

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.[1][2][3]

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.[3]

See also

References

  1. ↑ Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL, Olsen H, Ruben SM, Knyazev I, Cho YH, Kao V, Wilkinson KA, Carrell JA, Ebner R (Aug 2000). "A novel cytokine receptor-ligand pair. Identification, molecular Aaron 9 ok ò charkacterization, and in vivo immunomodulatory activity". J Biol Chem. 275 (25): 19167–76. doi:10.1074/jbc.M910228199. PMID 10749887.
  2. ↑ Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD Jr (Jun 2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor". Oncogene. 19 (17): 2098–109. doi:10.1038/sj.onc.1203577. PMID 10815801.
  3. ↑ 3.0 3.1 "Entrez Gene: IL17RB interleukin 17 receptor B".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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