Glucose-6-phosphate dehydrogenase deficiency epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]
Overview
G6PD deficiency is affecting 400 million people worldwide. atients of all age groups may develop favism, but more often and severe in childern. African, Middle Eastern and South Asian people are affected the most. Men are more commonly affected by G6PD deficiency.
Epidemiology and Demographics
Prevalence
- G6PD deficiency is affecting 400 million people worldwide. [1]
Case-fatality rate/Mortality rate
- G6PD deficiency resulted in 4,100 deaths in 2013 and 3,400 deaths in 1990[2]
Age
- Patients of all age groups may develop favism (acute hemolytic anemia from eating fava beans ), but more often and severe in childern.
Race
- African, Middle Eastern and South Asian people are affected the most.
Gender
- Men are more commonly affected by G6PD deficiency than women, because it is an X-linked recessive disorder.
Region
- The majority of G6PD deficiency cases are reported in African, Middle Eastern and South Asian people. [3]
References
- ↑ Mason PJ, Bautista JM, Gilsanz F (September 2007). "G6PD deficiency: the genotype-phenotype association". Blood Rev. 21 (5): 267–83. doi:10.1016/j.blre.2007.05.002. PMID 17611006.
- ↑ "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 385 (9963): 117–71. January 2015. doi:10.1016/S0140-6736(14)61682-2. PMC 4340604. PMID 25530442.
- ↑ Beutler E (January 1991). "Glucose-6-phosphate dehydrogenase deficiency". N. Engl. J. Med. 324 (3): 169–74. doi:10.1056/NEJM199101173240306. PMID 1984194.