Glucose-6-phosphate dehydrogenase deficiency classification: Difference between revisions

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==Overview==
==Overview==
'''Glucose-6-phosphate dehydrogenase (G6PD) deficiency''' is an [[Sex-linked|X-linked recessive]] [[hereditary disease]] featuring abnormally low levels of the [[G6PD]] enzyme, which plays an important role in [[red blood cell]] function. Individuals with the disease may exhibit non-immune [[hemolytic anemia]] in response to a number of causes. It is closely linked to '''[[favism]]''', a disorder characterized by a hemolytic reaction to consumption of [[Vicia faba|broad bean]]s, with a name derived from the [[Italian language|Italian]] name of the broad bean (''fava''). Sometimes the name, [[favism]], is alternatively used to refer to the enzyme
 
deficiency as a whole.
==Classification==
==Classification==
There are four forms of [[G6PD]]:
#  
# [[Hereditary nonspherocytic hemolytic anemia]]
# Severe deficiency
# Mild deficiency
# Non-deficient variant
# [[Favism]] is a disorder characterized by [[hemolytic anemia]] in response to ingestion of fava beans. [[Favism]] as a diagnosis has been known since antiquity, perhaps in relation to Pythagoras, among others. All individuals with favism show [[G6PD deficiency]]. However, not all individuals with [[G6PD deficiency]] show [[favism]]. For example, in a small study of 757 Saudi men, more than 42% showed [[G6PD deficiency]], but none reported symptoms of [[favism]], despite fava in the diet.<ref>{{cite web |url=http://www.kfshrc.edu.sa/annals/166/95-371.html |title=Common G6PD variant from Saudi population |accessdate=2007-10-28 |format= |work=}}</ref> [[Favism]] is known to be more prevalent in infants and children, and [[G6PD]] genetic variant can influence chemical sensitivity. Other than this, the detailed chemical relationship between [[favism]] and [[G6PD]] is not well known.


==References==
==References==

Revision as of 21:05, 20 February 2018

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