Glucose-6-phosphate dehydrogenase deficiency classification: Difference between revisions
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{{Glucose-6-phosphate dehydrogenase deficiency}} | {{Glucose-6-phosphate dehydrogenase deficiency}} | ||
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==Overview== | ==Overview== | ||
G6PD deficiency may be classified to into 5 subtypes and gives some approximation of the magnitude of hemolysis an individual may incur in the setting of an oxidative stress. | |||
==Classification== | ==Classification== | ||
{{Glucose-6-phosphate dehydrogenase deficiency}} | |||
G6PD deficiency may be classified according to World Health Organization into 5 subtypes: <ref name="pmid2633878">{{cite journal |vauthors= |title=Glucose-6-phosphate dehydrogenase deficiency. WHO Working Group |journal=Bull. World Health Organ. |volume=67 |issue=6 |pages=601–11 |date=1989 |pmid=2633878 |pmc=2491315 |doi= |url=}}</ref><ref name="pmid16225031">{{cite journal |vauthors=Frank JE |title=Diagnosis and management of G6PD deficiency |journal=Am Fam Physician |volume=72 |issue=7 |pages=1277–82 |date=October 2005 |pmid=16225031 |doi= |url=}}</ref> | |||
* Class I: Severe deficiency (<10% activity) with chronic [[hemolytic anemia]]. | |||
* Class II: Severe deficiency (<10% activity), with intermittent [[hemolysis]]. G6PD Mediterranean deficiency is a class II deficiency. | |||
* Class III: Moderate deficiency (10-60% activity), hemolysis with significant oxidant stress. G6PD A- deficiency is a class III deficiency. | |||
* Class IV: No [[enzyme]] deficiency or [[hemolysis]], no clinical sequelae. it has G6PD B, normal wild-type [[enzyme]] | |||
* Class V: Increased [[enzyme]] activity (more than twice normal), no clinical sequela | |||
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==References== | ==References== | ||
Latest revision as of 14:30, 17 October 2018
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Glucose-6-phosphate dehydrogenase deficiency Microchapters |
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Differentiating Glucose-6-phosphate dehydrogenase deficiency from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Glucose-6-phosphate dehydrogenase deficiency classification On the Web |
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American Roentgen Ray Society Images of Glucose-6-phosphate dehydrogenase deficiency classification |
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FDA on Glucose-6-phosphate dehydrogenase deficiency classification |
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CDC on Glucose-6-phosphate dehydrogenase deficiency classification |
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Glucose-6-phosphate dehydrogenase deficiency classification in the news |
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Blogs on Glucose-6-phosphate dehydrogenase deficiency classification |
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Directions to Hospitals Treating Glucose-6-phosphate dehydrogenase deficiency |
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Risk calculators and risk factors for Glucose-6-phosphate dehydrogenase deficiency classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]
Overview
G6PD deficiency may be classified to into 5 subtypes and gives some approximation of the magnitude of hemolysis an individual may incur in the setting of an oxidative stress.
Classification
|
Glucose-6-phosphate dehydrogenase deficiency Microchapters |
|
Differentiating Glucose-6-phosphate dehydrogenase deficiency from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Glucose-6-phosphate dehydrogenase deficiency classification On the Web |
|
American Roentgen Ray Society Images of Glucose-6-phosphate dehydrogenase deficiency classification |
|
FDA on Glucose-6-phosphate dehydrogenase deficiency classification |
|
CDC on Glucose-6-phosphate dehydrogenase deficiency classification |
|
Glucose-6-phosphate dehydrogenase deficiency classification in the news |
|
Blogs on Glucose-6-phosphate dehydrogenase deficiency classification |
|
Directions to Hospitals Treating Glucose-6-phosphate dehydrogenase deficiency |
|
Risk calculators and risk factors for Glucose-6-phosphate dehydrogenase deficiency classification |
G6PD deficiency may be classified according to World Health Organization into 5 subtypes: [1][2]
- Class I: Severe deficiency (<10% activity) with chronic hemolytic anemia.
- Class II: Severe deficiency (<10% activity), with intermittent hemolysis. G6PD Mediterranean deficiency is a class II deficiency.
- Class III: Moderate deficiency (10-60% activity), hemolysis with significant oxidant stress. G6PD A- deficiency is a class III deficiency.
- Class IV: No enzyme deficiency or hemolysis, no clinical sequelae. it has G6PD B, normal wild-type enzyme
- Class V: Increased enzyme activity (more than twice normal), no clinical sequela