Glucose-6-phosphate dehydrogenase deficiency causes: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 3: Line 3:
{{Glucose-6-phosphate dehydrogenase deficiency}}
{{Glucose-6-phosphate dehydrogenase deficiency}}


{{CMG}}; {{AE}}{{MA}} [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu]
{{CMG}}; {{AE}}{{MA}} [mailto:malihash@bidmc.harvard.edu]
==Overview==
==Overview==
Disease name] may be caused by [cause1], [cause2], or [cause3].
The most common cause of G6PD deficiency is due to genetic disorder. Less common cause of G6PD deficiency include neutrophil dysfunction.  
 
OR
 
Common causes of [disease] include [cause1], [cause2], and [cause3].
 
OR
 
The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
 
OR
 
The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click [[Pericarditis causes#Overview|here]].


==Causes==
==Causes==
===Life-threatening Causes===
*Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of [[disease name]], however complications resulting from untreated [[disease name]] is common.
*Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
*[Cause] is a life-threatening cause of [disease].
===Common Causes===
===Common Causes===
G6PD deficiency is an X-linked disorder.
Common cause of G6PD deficiency may include:
* Genetic: G6PD deficiency is an [[X-linked]] disorder  


Common causes of G6PD deficiency may include:
===Less Common Causes===
* Genetic :  
Less common causes of G6PD deficiency include:
* [[Neutrophil]] dysfunction in severe G6PD deficiency ( <20 percent activity ) <ref name="pmid7055648">{{cite journal |vauthors=Vives Corrons JL, Feliu E, Pujades MA, Cardellach F, Rozman C, Carreras A, Jou JM, Vallespí MT, Zuazu FJ |title=Severe-glucose-6-phosphate dehydrogenase (G6PD) deficiency associated with chronic hemolytic anemia, granulocyte dysfunction, and increased susceptibility to infections: description of a new molecular variant (G6PD Barcelona) |journal=Blood |volume=59 |issue=2 |pages=428–34 |date=February 1982 |pmid=7055648 |doi= |url=}}</ref>


*
*
*[Cause2]
*[Cause3]


===Genetic Causes===
The gene G6PD is located in the distal long arm of the [[X chromosome]] at the Xq28 [[Locus (genetics)|locus]]. G6PD B, is the wild type or normal.<ref name="pmid7949118">{{cite journal |vauthors=Beutler E |title=G6PD deficiency |journal=Blood |volume=84 |issue=11 |pages=3613–36 |date=December 1994 |pmid=7949118 |doi= |url=}}</ref>


OR
The development of G6PD deficency is the result of [[Missense mutation|missense]] point [[Mutation|mutations]] and also a few deletions<ref name="pmid2190319">{{cite journal |vauthors=Beutler E |title=The genetics of glucose-6-phosphate dehydrogenase deficiency |journal=Semin. Hematol. |volume=27 |issue=2 |pages=137–64 |date=April 1990 |pmid=2190319 |doi= |url=}}</ref>
 
 
*[Disease name] is caused by an infection with [pathogen name].
*[Pathogen name] is caused by [pathogen name].
 
===Less Common Causes===
Less common causes of G6PD deficiency  include:
* Neutrophil dysfunction in severe G6PD deficiency ( <20 percent activity ) <ref name="pmid7055648">{{cite journal |vauthors=Vives Corrons JL, Feliu E, Pujades MA, Cardellach F, Rozman C, Carreras A, Jou JM, Vallespí MT, Zuazu FJ |title=Severe-glucose-6-phosphate dehydrogenase (G6PD) deficiency associated with chronic hemolytic anemia, granulocyte dysfunction, and increased susceptibility to infections: description of a new molecular variant (G6PD Barcelona) |journal=Blood |volume=59 |issue=2 |pages=428–34 |date=February 1982 |pmid=7055648 |doi= |url=}}</ref>
 
*
*
*[Cause2]
*[Cause3]
===Genetic Causes===
*G6PD deficiency is caused by a mutation in the [gene name] gene.


===Causes by Organ System===
===Causes by Organ System===
Line 92: Line 63:
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" | X-linked disorder
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
Line 170: Line 141:
===Causes in Alphabetical Order===
===Causes in Alphabetical Order===
List the causes of the disease in alphabetical order:
List the causes of the disease in alphabetical order:
<div style="-moz-column-count:3; column-count:3;">
* Genitic
* Cause 1
* [[Neutrophil]] dysfunction
* Cause 2
<div style="-moz-column-count:3; column-count:3;"></div>
* Cause 3
* Cause 4
* Cause 5
* Cause 6
* Cause 7
* Cause 8
* Cause 9
* Cause 10
</div>


==References==
==References==
Line 189: Line 151:
{{WS}}
{{WS}}
[[Category: (name of the system)]]
[[Category: (name of the system)]]
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com]
Please help WikiDoc by adding content here.  It's easy!  Click  [[Help:How to Edit a Page|here]]  to learn about editing.
==Overview==
'''Glucose-6-phosphate dehydrogenase (G6PD) deficiency''' is an [[Sex-linked|X-linked recessive]] [[hereditary disease]] featuring abnormally low levels of the [[G6PD]] enzyme, which plays an important role in [[red blood cell]] function. Individuals with the disease may exhibit non-immune [[hemolytic anemia]] in response to a number of causes. It is closely linked to '''[[favism]]''', a disorder characterized by a hemolytic reaction to consumption of [[Vicia faba|broad bean]]s, with a name derived from the [[Italian language|Italian]] name of the broad bean (''fava''). Sometimes the name, [[favism]], is alternatively used to refer to the enzyme
deficiency as a whole.
==References==
{{reflist|2}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
[[Category:Disease]]
[[Category:Hematology]]
[[Category:Mature chapter]]
[[Need content]]

Latest revision as of 17:03, 27 August 2018


Glucose-6-phosphate dehydrogenase deficiency Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Glucose-6-phosphate dehydrogenase deficiency from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Glucose-6-phosphate dehydrogenase deficiency causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Glucose-6-phosphate dehydrogenase deficiency causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Glucose-6-phosphate dehydrogenase deficiency causes

CDC on Glucose-6-phosphate dehydrogenase deficiency causes

Glucose-6-phosphate dehydrogenase deficiency causes in the news

Blogs on Glucose-6-phosphate dehydrogenase deficiency causes

Directions to Hospitals Treating Glucose-6-phosphate dehydrogenase deficiency

Risk calculators and risk factors for Glucose-6-phosphate dehydrogenase deficiency causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2] [3]

Overview

The most common cause of G6PD deficiency is due to genetic disorder. Less common cause of G6PD deficiency include neutrophil dysfunction.

Causes

Common Causes

Common cause of G6PD deficiency may include:

  • Genetic: G6PD deficiency is an X-linked disorder

Less Common Causes

Less common causes of G6PD deficiency include:

  • Neutrophil dysfunction in severe G6PD deficiency ( <20 percent activity ) [1]

Genetic Causes

The gene G6PD is located in the distal long arm of the X chromosome at the Xq28 locus. G6PD B, is the wild type or normal.[2]

The development of G6PD deficency is the result of missense point mutations and also a few deletions[3]

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic X-linked disorder
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order:

References

  1. ↑ Vives Corrons JL, Feliu E, Pujades MA, Cardellach F, Rozman C, Carreras A, Jou JM, Vallespí MT, Zuazu FJ (February 1982). "Severe-glucose-6-phosphate dehydrogenase (G6PD) deficiency associated with chronic hemolytic anemia, granulocyte dysfunction, and increased susceptibility to infections: description of a new molecular variant (G6PD Barcelona)". Blood. 59 (2): 428–34. PMID 7055648.
  2. ↑ Beutler E (December 1994). "G6PD deficiency". Blood. 84 (11): 3613–36. PMID 7949118.
  3. ↑ Beutler E (April 1990). "The genetics of glucose-6-phosphate dehydrogenase deficiency". Semin. Hematol. 27 (2): 137–64. PMID 2190319.

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Glucose-6-phosphate_dehydrogenase_deficiency_causes&oldid=1492158"