Fever of unknown origin laboratory findings: Difference between revisions
Jump to navigation
Jump to search
m (Changes made per Mahshid's request) |
|||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{| class="infobox" style="float: right;" | {| class="infobox" style="float: right;" | ||
| style="vertical-align: middle; padding: 5px;" align=center | [[File:Siren.gif|30px|link=Fever of unknown origin resident survival guide]] | | style="vertical-align: middle; padding: 5px;" align="center" |[[File:Siren.gif|30px|link=Fever of unknown origin resident survival guide]] | ||
| style="vertical-align: middle; padding: 5px;" align=center | [[Fever of unknown origin resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']] | | style="vertical-align: middle; padding: 5px;" align="center" |[[Fever of unknown origin resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']] | ||
|} | |} | ||
{{Fever of unknown origin}} | {{Fever of unknown origin}} | ||
| Line 15: | Line 15: | ||
==Laboratory Workup of Fever of Unknown Origin== | ==Laboratory Workup of Fever of Unknown Origin== | ||
* [[Complete blood count|Complete blood count with differential]] | Laboratory work up for FUO is directed by history and physical examination which may provide some clues helping in narrowing down investigations. However some laboratory investigations listed below are mandatory in cases of FUO.<ref name="pmid27964789">{{cite journal| author=Mulders-Manders CM, Simon A, Bleeker-Rovers CP| title=Rheumatologic diseases as the cause of fever of unknown origin. | journal=Best Pract Res Clin Rheumatol | year= 2016 | volume= 30 | issue= 5 | pages= 789-801 | pmid=27964789 | doi=10.1016/j.berh.2016.10.005 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27964789 }}</ref> | ||
* [[Basic metabolic panel]] | |||
* [[Liver function test]] including aminotransferases ([[AST]] and [[ALT]]), [[LDH]], [[bilirubin]], and [[alkaline phosphatase]] | *[[Complete blood count|Complete blood count with differential]] | ||
* [[Creatine kinase]] | *[[Hemoglobin]] | ||
* [[Blood cultures]] (at least 2 sets) | *[[Basic metabolic panel]] | ||
* [[Urinalysis]] with microscopic examination | *[[Liver function test]] including aminotransferases ([[AST]] and [[ALT]]), [[LDH]], [[bilirubin]], and [[alkaline phosphatase]] | ||
* [[Urine culture]]s | *[[Creatine kinase]] | ||
* [[Erythrocyte sedimentation rate]] | *[[Blood cultures]] (at least 2 sets) | ||
* [[C-reactive protein]] | *[[Urinalysis]] with microscopic examination | ||
* [[Gamma-glutamyl transferase]] | *[[Urine culture]]s | ||
* [[Coombs test]] | *[[Erythrocyte sedimentation rate]] | ||
*[[C-reactive protein]] | |||
*[[Gamma-glutamyl transferase]] | |||
*[[Antinuclear antibodies]] | |||
*[[Rheumatoid factor]] | |||
*[[Serum protein electrophoresis]] | |||
*[[Tuberculin skin test]] | |||
*[[Chest X ray]] | |||
*Abdominal [[Ultrasonography]] | |||
Other Laboratory work up done in case FUO other than mandatory work up are :<ref>{{Cite journal| issn = 1058-4838| volume = 24| issue = 3| pages = 291–300; quiz 301-302| last = Hirschmann| first = J. V.| title = Fever of unknown origin in adults| journal = Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America| date = 1997-03| pmid = 9114175}}</ref><ref>{{Cite journal| doi = 10.1016/j.idc.2007.09.004| issn = 0891-5520| volume = 21| issue = 4| pages = 1137–1187, xi| last = Cunha| first = Burke A.| title = Fever of unknown origin: focused diagnostic approach based on clinical clues from the history, physical examination, and laboratory tests| journal = Infectious Disease Clinics of North America| date = 2007-12| pmid = 18061092}}</ref> | |||
* HIV serology | |||
* [[Coombs test (patient information)|Coombs test]] | |||
* [[Cold agglutinins]] | * [[Cold agglutinins]] | ||
* [[ | * [[Heterophile antibody test]] | ||
* [[Thyroid peroxidase]] and [[anti thyroid antibody test]] | |||
* [[Thyroid peroxidase]] and [[ | * [[Bone marrow biopsy]] | ||
* [[ | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Ailments of unknown etiology]] | [[Category:Ailments of unknown etiology]] | ||
Revision as of 12:54, 25 January 2021
|
Resident Survival Guide |
|
Fever of unknown origin Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Fever of unknown origin laboratory findings On the Web |
|
American Roentgen Ray Society Images of Fever of unknown origin laboratory findings |
|
Risk calculators and risk factors for Fever of unknown origin laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; fever/pyrexia of obscured/undetermined/uncertain/unidentifiable/unknown focus/origin/source; fever/pyrexia without a focus/origin/source; FUO; PUO
Laboratory Workup of Fever of Unknown Origin
Laboratory work up for FUO is directed by history and physical examination which may provide some clues helping in narrowing down investigations. However some laboratory investigations listed below are mandatory in cases of FUO.[1]
- Complete blood count with differential
- Hemoglobin
- Basic metabolic panel
- Liver function test including aminotransferases (AST and ALT), LDH, bilirubin, and alkaline phosphatase
- Creatine kinase
- Blood cultures (at least 2 sets)
- Urinalysis with microscopic examination
- Urine cultures
- Erythrocyte sedimentation rate
- C-reactive protein
- Gamma-glutamyl transferase
- Antinuclear antibodies
- Rheumatoid factor
- Serum protein electrophoresis
- Tuberculin skin test
- Chest X ray
- Abdominal Ultrasonography
Other Laboratory work up done in case FUO other than mandatory work up are :[2][3]
- HIV serology
- Coombs test
- Cold agglutinins
- Heterophile antibody test
- Thyroid peroxidase and anti thyroid antibody test
- Bone marrow biopsy
References
- ↑ Mulders-Manders CM, Simon A, Bleeker-Rovers CP (2016). "Rheumatologic diseases as the cause of fever of unknown origin". Best Pract Res Clin Rheumatol. 30 (5): 789–801. doi:10.1016/j.berh.2016.10.005. PMID 27964789.
- ↑ Hirschmann, J. V. (1997-03). "Fever of unknown origin in adults". Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 24 (3): 291–300, quiz 301-302. ISSN 1058-4838. PMID 9114175. Check date values in:
|date=(help) - ↑ Cunha, Burke A. (2007-12). "Fever of unknown origin: focused diagnostic approach based on clinical clues from the history, physical examination, and laboratory tests". Infectious Disease Clinics of North America. 21 (4): 1137–1187, xi. doi:10.1016/j.idc.2007.09.004. ISSN 0891-5520. PMID 18061092. Check date values in:
|date=(help)