Fever of unknown origin medical therapy
Fever of unknown origin Microchapters
Fever of unknown origin medical therapy On the Web
American Roentgen Ray Society Images of Fever of unknown origin medical therapy
Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; fever/pyrexia of obscured/undetermined/uncertain/unidentifiable/unknown focus/origin/source; fever/pyrexia without a focus/origin/source; FUO; PUO
Since FUO can have variety of etiologies therefore it does not have a standard treatment regimen. However the treatment is usually directed towards the target from potential clues in the History and Physical examination.
Use of empiric antibiotics should not be encouraged unless the patient is neutropenic or immunocompromised, so that proper workup can be done and a more targeted treatment be given.
- Steroids should not be given early as it can mask effects of many diseases.
- however they can be given early in cases of Giant cell temporal arteritis to prevent blindness.
- they are used in rheumatologic causes of FUO.
Non-steroidal anti-inflammatory drugs are given when no cause is found despite extensive work up.
Interleukin 1 antagonist are give in cases of autoimmune disorders. If no symptomatic improvement occurs after 2 weeks drug should be stopped.
- Mulders-Manders C, Simon A, Bleeker-Rovers C (2015). "Fever of unknown origin". Clin Med (Lond). 15 (3): 280–4. doi:10.7861/clinmedicine.15-3-280. PMC 4953114. PMID 26031980.
- Wright WF, Auwaerter PG (2020). "Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma". Open Forum Infect Dis. 7 (5): ofaa132. doi:10.1093/ofid/ofaa132. PMC 7237822 Check
|pmc=value (help). PMID 32462043 Check