Fatigue resident survival guide

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Fatigue
Resident Survival Guide
Overview
Causes
FIRE
Diagnosis
Treatment
Do's
Don'ts

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mounika Lakhmalla, MBBS[2]Tayyaba Ali, M.D.[3]

Synonyms and keywords:: Weakness, Tiredness, Lethargy, Debility

Overview

Fatigue is a common nonspecific symptom due to a wide range of etiologies.Patients often use this term to describe a range of issues like difficulty initiating activity ; decreased capacity to maintain activity ; Trouble with concentration, memory, and emotional stability; or sleepiness or an uncontrollable need to sleep. The term fatigue can sometimes be used synonymously with Tiredness. Fatigue can present alone as a primary symptom or in association with other localizing symptoms.

Causes

Life Threatening Causes

Life-threatening causes include conditions that may result in death or permanent disability within 24 hours if left untreated.

Common Causes

  • Multiple sclerosis[3]
  • After malignancy treatment, patients can experience different patterns of fatigue from chemotherapy, radiation treatment, or surgery[4].

Diagnosis

The approach to diagnosis of fatigue is based on a step-wise testing strategy. Below is an algorithm summarising the identification and laboratory diagnosis of fatigue.

  • Diagnostic evaluation of fatigue when it presents as a predominant symptom includes a detailed history and physical examination, basic laboratory studies, and updated cancer screening interventions.
  • Additional diagnostic testing depends on associated localized findings.
  • Extensive laboratory studies with out a suggestive history or physical exam findings is of limited diagnostic utility while evaluating chronic fatigue[5][6].


 
 
 
 
 
 
 
 
 
 
 
 
Seek proper history, ask patients to describe in their own words, what do they mean by fatigue?
This will help distinguish fatigue from
somnolence
muscle weakness
The history should also determine the characteristics, severity, and temporal pattern of fatigue:
❑ Onset – Abrupt or gradual, relationship to illness or life event
❑ Course – Stable, improving, or worsening
❑ Duration and daily pattern
❑ Factors that alleviate or exacerbate it
❑ Impact on daily life – Ability to work, socialize, participate in family activities
❑ Accommodations that the patient/family has had to make to deal with symptom
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Physical examination
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Characterize the cardiac symptoms:
❑ Dyspnea on exertion
❑ orthopnea
❑ leg swelling Examine the patient:
❑elevated jugular venous distension
❑ peripheral edema
❑ S3 gallop
❑ inspiratory rales
 
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Treatment

Shown below is an algorithm summarizing the treatment of [[disease name]] according the the [...] guidelines.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Do's

  • The content in this section is in bullet points.

Don'ts

  • The content in this section is in bullet points.

References

  1. Grimstad T, Norheim KB (2016). "Fatigue in inflammatory bowel disease". Tidsskr Nor Laegeforen. 136 (20): 1721–1724. doi:10.4045/tidsskr.16.0134. PMID 27830906.
  2. Swain MG, Jones DEJ (2019). "Fatigue in chronic liver disease: New insights and therapeutic approaches". Liver Int. 39 (1): 6–19. doi:10.1111/liv.13919. PMID 29935104.
  3. Akcali A, Zengin F, Aksoy SN, Zengin O (2017). "Fatigue in Multiple Sclerosis: Is it related to cytokines and hypothalamic-pituitary-adrenal axis?". Mult Scler Relat Disord. 15: 37–41. doi:10.1016/j.msard.2017.03.004. PMID 28641771.
  4. Greenberg DB (2002). "Clinical Dimensions of Fatigue". Prim Care Companion J Clin Psychiatry. 4 (3): 90–93. doi:10.4088/pcc.v04n0301. PMC 181235. PMID 15014735.
  5. Ridsdale L, Evans A, Jerrett W, Mandalia S, Osler K, Vora H (1993). "Patients with fatigue in general practice: a prospective study". BMJ. 307 (6896): 103–6. doi:10.1136/bmj.307.6896.103. PMC 1693499. PMID 8343705.
  6. Lane TJ, Matthews DA, Manu P (1990). "The low yield of physical examinations and laboratory investigations of patients with chronic fatigue". Am J Med Sci. 299 (5): 313–8. doi:10.1097/00000441-199005000-00005. PMID 2337122.


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References