Epilepsy medical therapy: Difference between revisions
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*** The initial dose is 2-3 mg/kg per day divided into at least two time. | *** The initial dose is 2-3 mg/kg per day divided into at least two time. | ||
*** The maximum dosing is 10 mg/kg three-times-daily. | *** The maximum dosing is 10 mg/kg three-times-daily. | ||
*** The most common side effects of this drug are GI disturbance, rash, hyponatremia and fluid retention.<ref name="pmid18981374">{{cite journal |vauthors=Hirsch LJ, Arif H, Nahm EA, Buchsbaum R, Resor SR, Bazil CW |title=Cross-sensitivity of skin rashes with antiepileptic drug use |journal=Neurology |volume=71 |issue=19 |pages=1527–34 |date=November 2008 |pmid=18981374 |doi=10.1212/01.wnl.0000334295.50403.4c |url=}}</ref> (1,5) | *** The most common side effects of this drug are GI disturbance, rash, hyponatremia and fluid retention.<ref name="pmid18981374">{{cite journal |vauthors=Hirsch LJ, Arif H, Nahm EA, Buchsbaum R, Resor SR, Bazil CW |title=Cross-sensitivity of skin rashes with antiepileptic drug use |journal=Neurology |volume=71 |issue=19 |pages=1527–34 |date=November 2008 |pmid=18981374 |doi=10.1212/01.wnl.0000334295.50403.4c |url=}}</ref> (1,5) | ||
** Eslicarbazepin | ** Eslicarbazepin | ||
** Lacosamide | ** Lacosamide | ||
Revision as of 00:01, 5 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
overview
Medical Therapy
Pharmacologic medical therapies for epilepsy is antiseizure drugs such as:
- Drugs that affect voltage-dependent Na+ channels
- Carbamazepin:
- The initial dose is 2-3 mg/kg per day divided into at least two time.
- The maximum dosing is 10 mg/kg three-times-daily.
- The most common side effects of this drug are GI disturbance, rash, hyponatremia and fluid retention.[1] (1,5)
- Eslicarbazepin
- Lacosamide
- Oxcarbazepine
- Phenytoin
- Rufinamide
- Carbamazepin:
- Drugs that affect Ca currents
- Ethosuximide
- Drugs that affect GABA activity
- Benzodiazepines
- Phenobarbital
- Tiagabine
- Vigabatrin
- Drugs that affect glutamate receptor
- Perampanel
- Drugs with multiple mechanisms of action
- Felbamate
- Topiramate
- Valporate
- Drugs with other mechanisms of action
- Brivaracetam
- Gabapentin
- Levetiracetam
- Pregabalin
References
- ↑ Hirsch LJ, Arif H, Nahm EA, Buchsbaum R, Resor SR, Bazil CW (November 2008). "Cross-sensitivity of skin rashes with antiepileptic drug use". Neurology. 71 (19): 1527–34. doi:10.1212/01.wnl.0000334295.50403.4c. PMID 18981374.