Ependymoma risk factors: Difference between revisions

Jump to navigation Jump to search
Line 10: Line 10:
*''ERBB2'', ''ERBB4'', and human telomerase reverse transcriptase ''TERT'' gene expression promote tumor cell proliferation, contributing to aggressive tumor behavior.<ref name=Wikipedia> Ependymoma https://en.wikipedia.org/wiki/Pediatric_ependymoma#Cell_of_origin. URL Accessed on 10 08 2015</ref>
*''ERBB2'', ''ERBB4'', and human telomerase reverse transcriptase ''TERT'' gene expression promote tumor cell proliferation, contributing to aggressive tumor behavior.<ref name=Wikipedia> Ependymoma https://en.wikipedia.org/wiki/Pediatric_ependymoma#Cell_of_origin. URL Accessed on 10 08 2015</ref>
*High expression of epidermal growth factor receptor ''EGFR'' correlates with unfavorable outcome.<ref name="pmid16609018">{{cite journal| author=Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B et al.| title=Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma. | journal=Clin Cancer Res | year= 2006 | volume= 12 | issue= 7 Pt 1 | pages= 2070-9 | pmid=16609018 | doi=10.1158/1078-0432.CCR-05-2363 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16609018  }} </ref>
*High expression of epidermal growth factor receptor ''EGFR'' correlates with unfavorable outcome.<ref name="pmid16609018">{{cite journal| author=Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B et al.| title=Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma. | journal=Clin Cancer Res | year= 2006 | volume= 12 | issue= 7 Pt 1 | pages= 2070-9 | pmid=16609018 | doi=10.1158/1078-0432.CCR-05-2363 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16609018  }} </ref>
*Over-expression of [[kinetochore]] proteins and down-regulation of [[metallothionein|metallothioneins]] are associated with recurrence in ependymomas.<ref name="pmid20885975">{{cite journal| author=Peyre M, Commo F, Dantas-Barbosa C, Andreiuolo F, Puget S, Lacroix L et al.| title=Portrait of ependymoma recurrence in children: biomarkers of tumor progression identified by dual-color microarray-based gene expression analysis. | journal=PLoS One | year= 2010 | volume= 5 | issue= 9 | pages= e12932 | pmid=20885975 | doi=10.1371/journal.pone.0012932 | pmc=PMC2945762 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20885975  }} </ref>
*Over-expression of [[kinetochore]] proteins and down-regulation of [[metallothionein|metallothioneins]] are associated with recurrence of ependymomas.<ref name="pmid20885975">{{cite journal| author=Peyre M, Commo F, Dantas-Barbosa C, Andreiuolo F, Puget S, Lacroix L et al.| title=Portrait of ependymoma recurrence in children: biomarkers of tumor progression identified by dual-color microarray-based gene expression analysis. | journal=PLoS One | year= 2010 | volume= 5 | issue= 9 | pages= e12932 | pmid=20885975 | doi=10.1371/journal.pone.0012932 | pmc=PMC2945762 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20885975  }} </ref>


==References==
==References==

Revision as of 18:53, 15 October 2015

Ependymoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Epidemiology and Demographics

Risk Factors

Differentiating Ependymoma from other Diseases

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Staging

Laboratory Findings

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Ependymoma risk factors On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ependymoma risk factors

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ependymoma risk factors

CDC on Ependymoma risk factors

Ependymoma risk factors in the news

Blogs on Ependymoma risk factors

Directions to Hospitals Treating Ependymoma

Risk calculators and risk factors for Ependymoma risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]

Overview

Common risk factors in the development of ependymoma are certain hereditary diseases (neurofibromatosis type II and Turcot syndrome), over-expression of kinetochore proteins, and down-regulation of metallothioneins.

Risk Factors

  • Children with certain hereditary diseases, such as neurofibromatosis type II (NF2), Turcot syndrome B, and MEN1 syndrome, have been found to be more frequently afflicted with ependymal tumors
  • increased occurrence of chromosome 1q and proteins such as tenascin C and epidermal growth factor is associated with increased risk for developing ependymal tumors.
  • ERBB2, ERBB4, and human telomerase reverse transcriptase TERT gene expression promote tumor cell proliferation, contributing to aggressive tumor behavior.[1]
  • High expression of epidermal growth factor receptor EGFR correlates with unfavorable outcome.[2]
  • Over-expression of kinetochore proteins and down-regulation of metallothioneins are associated with recurrence of ependymomas.[3]

References

  1. Ependymoma https://en.wikipedia.org/wiki/Pediatric_ependymoma#Cell_of_origin. URL Accessed on 10 08 2015
  2. Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B; et al. (2006). "Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma". Clin Cancer Res. 12 (7 Pt 1): 2070–9. doi:10.1158/1078-0432.CCR-05-2363. PMID 16609018.
  3. Peyre M, Commo F, Dantas-Barbosa C, Andreiuolo F, Puget S, Lacroix L; et al. (2010). "Portrait of ependymoma recurrence in children: biomarkers of tumor progression identified by dual-color microarray-based gene expression analysis". PLoS One. 5 (9): e12932. doi:10.1371/journal.pone.0012932. PMC 2945762. PMID 20885975.

Template:WikiDoc Sources