Endothelial lipase: Difference between revisions
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'''Endothelial lipase''' is a form of [[lipase]] secreted by the [[endothelial]] | '''Endothelial lipase''' is a form of [[lipase]] secreted by vascular [[endothelial]] cells in tissues with high metabolic rates and vascularization, such as the liver, lung, kidney, and | ||
thyroid gland.<ref name="pmid28540715">{{cite journal | vauthors=Yu JE, Han SY, Wolfson B, Zhou Q | title=The role of endothelial lipase in lipid metabolism, inflammation, and cancer| journal= [[Histology and Histopathology]] | volume=33 | issue=1 | pages=1-10 | year=2018 | doi=10.14670/HH-11-905 | PMC =5858721 | PMID = 28540715 }}</ref> Unlike the lipases that hydrolyze triglycerides, endothelial lipase primarily hydrolyzes [[phospholipid]]s.<ref name="pmid28540715" /> | |||
It was first characterized in 1999.<ref name="pmid10192396">{{cite journal |vauthors=Jaye M, Lynch KJ, Krawiec J |title=A novel endothelial-derived lipase that modulates HDL metabolism |journal=Nat. Genet. |volume=21 |issue=4 |pages=424–8 |year=1999 |pmid=10192396 |doi=10.1038/7766|display-authors=etal}}</ref> | It was first characterized in 1999.<ref name="pmid10192396">{{cite journal |vauthors=Jaye M, Lynch KJ, Krawiec J |title=A novel endothelial-derived lipase that modulates HDL metabolism |journal=Nat. Genet. |volume=21 |issue=4 |pages=424–8 |year=1999 |pmid=10192396 |doi=10.1038/7766|display-authors=etal}}</ref> | ||
Latest revision as of 08:59, 9 January 2019
| lipase, endothelial | |
|---|---|
| Identifiers | |
| Symbol | LIPG |
| Entrez | 9388 |
| HUGO | 6623 |
| OMIM | 603684 |
| RefSeq | NM_006033 |
| UniProt | Q9Y5X9 |
| Other data | |
| Locus | Chr. 18 q21.1 |
Endothelial lipase is a form of lipase secreted by vascular endothelial cells in tissues with high metabolic rates and vascularization, such as the liver, lung, kidney, and thyroid gland.[1] Unlike the lipases that hydrolyze triglycerides, endothelial lipase primarily hydrolyzes phospholipids.[1]
It was first characterized in 1999.[2]
References
- ↑ 1.0 1.1 Yu JE, Han SY, Wolfson B, Zhou Q (2018). "The role of endothelial lipase in lipid metabolism, inflammation, and cancer". Histology and Histopathology. 33 (1): 1–10. doi:10.14670/HH-11-905. PMC 5858721. PMID 28540715.
- ↑ Jaye M, Lynch KJ, Krawiec J, et al. (1999). "A novel endothelial-derived lipase that modulates HDL metabolism". Nat. Genet. 21 (4): 424–8. doi:10.1038/7766. PMID 10192396.
External links
- endothelial+lipase,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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