Protein tyrosine phosphatase
Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins.
PTPs are increasingly viewed as integral components of signal transduction cascades, despite little studied and ill-understood compared to Tyrosine Kinases.
PTPs have been implicated in regulation of many cellular processes, including, but not limited to:
- receptor type: PTPRA, PTPRB, PTPRC, PTPRD, PTPRE, PTPRF, PTPRG, PTPRH, PTPRJ, PTPRK, PTPRM, PTPRN, PTPRN2, PTPRO, PTPRQ, PTPRR, PTPRS, PTPRT, PTPRU, PTPRZ1, PTPRZ2
- non-receptor type: PTPN1, PTPN2, PTPN3, PTPN4, PTPN5, PTPN6, PTPN7, PTPN9, PTPN11, PTPN12, PTPN13, PTPN14, PTPN18, PTPN20A, PTPN20B, PTPN20C, PTPN21, PTPN22, PTPN23
- type IVA: PTP4A1, PTP4A2, PTP4A3
- mitochondrial: PTPMT1
- PTP Summary and Relevant Publications at Monash University
- MeSH Protein-Tyrosine-Phosphatase
- EC 220.127.116.11
- Alberts, Bruce (2002). Molecular Biology of the Cell Fourth Edition. NYC, NY: Farland Science. ISBN 0-8153-3218-1. pp 886-887.